| Field |
Value |
Language |
|
dc.contributor.author |
Hosseinpour Mashkani, SM |
|
|
dc.contributor.author |
Bishop, DP |
|
|
dc.contributor.author |
Raoufi-Rad, N |
|
|
dc.contributor.author |
Adlard, PA |
|
|
dc.contributor.author |
Shimoni, O
https://orcid.org/0000-0001-8822-1024
|
|
|
dc.contributor.author |
Golzan, SM |
|
|
dc.date.accessioned |
2023-04-17T00:29:27Z |
|
|
dc.date.available |
2023-04-17T00:29:27Z |
|
|
dc.identifier.citation |
Cells, 12, (8), pp. 1144 |
|
|
dc.identifier.issn |
2073-4409 |
|
|
dc.identifier.issn |
2073-4409 |
|
|
dc.identifier.uri |
http://hdl.handle.net/10453/169831
|
|
|
dc.description.abstract |
<jats:p>A mis-metabolism of transition metals (i.e., copper, iron, and zinc) in the brain has been recognised as a precursor event for aggregation of Amyloid-β plaques, a pathological hallmark of Alzheimer’s disease (AD). However, imaging cerebral transition metals in vivo can be extremely challenging. As the retina is a known accessible extension of the central nervous system, we examined whether changes in the hippocampus and cortex metal load are also mirrored in the retina. Laser ablation inductively coupled plasma-mass spectrometry (LA-ICP-MS) was used to visualise and quantify the anatomical distribution and load of Cu, Fe, and Zn in the hippocampus, cortex, and retina of 9-month-old Amyloid Precursor Protein/Presenilin 1 (APP/PS1, n = 10) and Wild Type (WT, n = 10) mice. Our results show a similar metal load trend between the retina and the brain, with the WT mice displaying significantly higher concentrations of Cu, Fe, and Zn in the hippocampus (p < 0.05, p < 0.0001, p < 0.01), cortex (p < 0.05, p = 0.18, p < 0.0001) and the retina (p < 0.001, p = 0.01, p < 0.01) compared with the APP/PS1 mice. Our findings demonstrate that dysfunction of the cerebral transition metals in AD is also extended to the retina. This could lay the groundwork for future studies on the assessment of transition metal load in the retina in the context of early AD.</jats:p> |
|
|
dc.language |
en |
|
|
dc.publisher |
MDPI |
|
|
dc.relation |
http://purl.org/au-research/grants/nhmrc/1105930
|
|
|
dc.relation |
ANZ Trustees Limited |
|
|
dc.relation |
http://purl.org/au-research/grants/nhmrc/GNT1105930
|
|
|
dc.relation.ispartof |
Cells |
|
|
dc.relation.isbasedon |
10.3390/cells12081144 |
|
|
dc.rights |
info:eu-repo/semantics/openAccess |
|
|
dc.title |
Distribution of Copper, Iron, and Zinc in the Retina, Hippocampus, and Cortex of the Transgenic APP/PS1 Mouse Model of Alzheimer’s Disease |
|
|
dc.type |
Journal Article |
|
|
utslib.citation.volume |
12 |
|
|
pubs.organisational-group |
/University of Technology Sydney |
|
|
pubs.organisational-group |
/University of Technology Sydney/Faculty of Health |
|
|
pubs.organisational-group |
/University of Technology Sydney/Faculty of Science |
|
|
pubs.organisational-group |
/University of Technology Sydney/Strength - CHT - Health Technologies |
|
|
pubs.organisational-group |
/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences |
|
|
pubs.organisational-group |
/University of Technology Sydney/Strength - IBMD - Initiative for Biomedical Devices |
|
|
pubs.organisational-group |
/University of Technology Sydney/Faculty of Health/Graduate School of Health |
|
|
pubs.organisational-group |
/University of Technology Sydney/Faculty of Health/Graduate School of Health/GSH.Orthoptics |
|
|
pubs.organisational-group |
/University of Technology Sydney/Centre for Health Technologies (CHT) |
|
|
utslib.copyright.status |
open_access |
* |
|
dc.date.updated |
2023-04-17T00:29:25Z |
|
|
pubs.issue |
8 |
|
|
pubs.publication-status |
Published online |
|
|
pubs.volume |
12 |
|
|
utslib.citation.issue |
8 |
|
