Can biomarkers be used to diagnose attention deficit hyperactivity disorder?

Chen, H; Yang, Y; Odisho, D; Wu, S; Yi, C; Oliver, BG

Can biomarkers be used to diagnose attention deficit hyperactivity disorder?

Chen, H

Yang, Y Odisho, D Wu, S Yi, C Oliver, BG

Permalink

Publisher:: Frontiers
Publication Type:: Journal Article
Citation:: Front Psychiatry, 2023, 14, pp. 1026616
Issue Date:: 2023

Open Access

Copyright Clearance Process

Recently Added
In Progress
Open Access

This item is open access.

Adobe PDF

Download full textAdobe PDF (812.04 kB)

View on publisher's site

View statistics

Full metadata record

Field	Value	Language
dc.contributor.author	Chen, H https://orcid.org/0000-0001-6883-3752
dc.contributor.author	Yang, Y
dc.contributor.author	Odisho, D
dc.contributor.author	Wu, S
dc.contributor.author	Yi, C
dc.contributor.author	Oliver, BG
dc.date.accessioned	2023-04-18T03:49:33Z
dc.date.available	2023-02-14
dc.date.available	2023-04-18T03:49:33Z
dc.date.issued	2023
dc.identifier.citation	Front Psychiatry, 2023, 14, pp. 1026616
dc.identifier.issn	1664-0640
dc.identifier.issn	1664-0640
dc.identifier.uri	http://hdl.handle.net/10453/169924
dc.description.abstract	Currently, the diagnosis of attention deficit hyperactivity disorder (ADHD) is solely based on behavioral tests prescribed by the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5). However, biomarkers can be more objective and accurate for diagnosis and evaluating treatment efficacy. Thus, this review aimed to identify potential biomarkers for ADHD. Search terms "ADHD," and "biomarker" combined with one of "protein," "blood/serum," "gene," and "neuro" were used to identify human and animal studies in PubMed, Ovid Medline, and Web of Science. Only papers in English were included. Potential biomarkers were categorized into radiographic, molecular, physiologic, or histologic markers. The radiographic analysis can identify specific activity changes in several brain regions in individuals with ADHD. Several molecular biomarkers in peripheral blood cells and some physiologic biomarkers were found in a small number of participants. There were no published histologic biomarkers for ADHD. Overall, most associations between ADHD and potential biomarkers were properly controlled. In conclusion, a series of biomarkers in the literature are promising as objective parameters to more accurately diagnose ADHD, especially in those with comorbidities that prevent the use of DSM-5. However, more research is needed to confirm the reliability of the biomarkers in larger cohort studies.
dc.format	Electronic-eCollection
dc.language	eng
dc.publisher	Frontiers
dc.relation	http://purl.org/au-research/grants/nhmrc/1158186
dc.relation	http://purl.org/au-research/grants/nhmrc/GNT1158186
dc.relation.ispartof	Front Psychiatry
dc.relation.isbasedon	10.3389/fpsyt.2023.1026616
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	1103 Clinical Sciences, 1117 Public Health and Health Services, 1701 Psychology
dc.title	Can biomarkers be used to diagnose attention deficit hyperactivity disorder?
dc.type	Journal Article
utslib.citation.volume	14
utslib.location.activity	Switzerland
utslib.for	1103 Clinical Sciences
utslib.for	1117 Public Health and Health Services
utslib.for	1701 Psychology
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney/Centre for Health Technologies (CHT)
utslib.copyright.status	open_access	*
dc.date.updated	2023-04-18T03:49:22Z
pubs.publication-status	Published online
pubs.volume	14

Abstract:

Currently, the diagnosis of attention deficit hyperactivity disorder (ADHD) is solely based on behavioral tests prescribed by the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5). However, biomarkers can be more objective and accurate for diagnosis and evaluating treatment efficacy. Thus, this review aimed to identify potential biomarkers for ADHD. Search terms "ADHD," and "biomarker" combined with one of "protein," "blood/serum," "gene," and "neuro" were used to identify human and animal studies in PubMed, Ovid Medline, and Web of Science. Only papers in English were included. Potential biomarkers were categorized into radiographic, molecular, physiologic, or histologic markers. The radiographic analysis can identify specific activity changes in several brain regions in individuals with ADHD. Several molecular biomarkers in peripheral blood cells and some physiologic biomarkers were found in a small number of participants. There were no published histologic biomarkers for ADHD. Overall, most associations between ADHD and potential biomarkers were properly controlled. In conclusion, a series of biomarkers in the literature are promising as objective parameters to more accurately diagnose ADHD, especially in those with comorbidities that prevent the use of DSM-5. However, more research is needed to confirm the reliability of the biomarkers in larger cohort studies.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/169924