Cellular and molecular features of COVID-19 associated ARDS: therapeutic relevance.

Scaramuzzo, G; Nucera, F; Asmundo, A; Messina, R; Mari, M; Montanaro, F; Johansen, MD; Monaco, F; Fadda, G; Tuccari, G; Hansbro, NG; Hansbro, PM; Hansel, TT; Adcock, IM; David, A; Kirkham, P; Caramori, G; Volta, CA; Spadaro, S

Cellular and molecular features of COVID-19 associated ARDS: therapeutic relevance.

Scaramuzzo, G Nucera, F Asmundo, A Messina, R Mari, M Montanaro, F Johansen, MD Monaco, F Fadda, G Tuccari, G Hansbro, NG Hansbro, PM Hansel, TT Adcock, IM David, A Kirkham, P Caramori, G Volta, CA Spadaro, S

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Publisher:: Springer Science and Business Media LLC
Publication Type:: Journal Article
Citation:: J Inflamm (Lond), 2023, 20, (1), pp. 11
Issue Date:: 2023-03-20

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Field	Value	Language
dc.contributor.author	Scaramuzzo, G
dc.contributor.author	Nucera, F
dc.contributor.author	Asmundo, A
dc.contributor.author	Messina, R
dc.contributor.author	Mari, M
dc.contributor.author	Montanaro, F
dc.contributor.author	Johansen, MD
dc.contributor.author	Monaco, F
dc.contributor.author	Fadda, G
dc.contributor.author	Tuccari, G
dc.contributor.author	Hansbro, NG
dc.contributor.author	Hansbro, PM
dc.contributor.author	Hansel, TT
dc.contributor.author	Adcock, IM
dc.contributor.author	David, A
dc.contributor.author	Kirkham, P
dc.contributor.author	Caramori, G
dc.contributor.author	Volta, CA
dc.contributor.author	Spadaro, S
dc.date.accessioned	2023-05-17T03:33:19Z
dc.date.available	2023-02-08
dc.date.available	2023-05-17T03:33:19Z
dc.date.issued	2023-03-20
dc.identifier.citation	J Inflamm (Lond), 2023, 20, (1), pp. 11
dc.identifier.issn	1476-9255
dc.identifier.issn	1476-9255
dc.identifier.uri	http://hdl.handle.net/10453/170361
dc.description.abstract	The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection can be asymptomatic or cause a disease (COVID-19) characterized by different levels of severity. The main cause of severe COVID-19 and death is represented by acute (or acute on chronic) respiratory failure and acute respiratory distress syndrome (ARDS), often requiring hospital admission and ventilator support.The molecular pathogenesis of COVID-19-related ARDS (by now termed c-ARDS) is still poorly understood. In this review we will discuss the genetic susceptibility to COVID-19, the pathogenesis and the local and systemic biomarkers correlated with c-ARDS and the therapeutic options that target the cell signalling pathways of c-ARDS.
dc.format	Electronic
dc.language	eng
dc.publisher	Springer Science and Business Media LLC
dc.relation.ispartof	J Inflamm (Lond)
dc.relation.isbasedon	10.1186/s12950-023-00333-2
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	1103 Clinical Sciences, 1115 Pharmacology and Pharmaceutical Sciences
dc.subject.classification	Immunology
dc.title	Cellular and molecular features of COVID-19 associated ARDS: therapeutic relevance.
dc.type	Journal Article
utslib.citation.volume	20
utslib.location.activity	England
utslib.for	1103 Clinical Sciences
utslib.for	1115 Pharmacology and Pharmaceutical Sciences
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - CFI - Centre for Inflammation
utslib.copyright.status	open_access	*
dc.date.updated	2023-05-17T03:33:15Z
pubs.issue	1
pubs.publication-status	Published online
pubs.volume	20
utslib.citation.issue	1

Abstract:

The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection can be asymptomatic or cause a disease (COVID-19) characterized by different levels of severity. The main cause of severe COVID-19 and death is represented by acute (or acute on chronic) respiratory failure and acute respiratory distress syndrome (ARDS), often requiring hospital admission and ventilator support.The molecular pathogenesis of COVID-19-related ARDS (by now termed c-ARDS) is still poorly understood. In this review we will discuss the genetic susceptibility to COVID-19, the pathogenesis and the local and systemic biomarkers correlated with c-ARDS and the therapeutic options that target the cell signalling pathways of c-ARDS.

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http://hdl.handle.net/10453/170361