The role of ATG16L2 in autophagy and disease.

Don Wai Luu, L; Kaakoush, NO; Castaño-Rodríguez, N

The role of ATG16L2 in autophagy and disease.

Don Wai Luu, L Kaakoush, NO Castaño-Rodríguez, N

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Publisher:: TAYLOR & FRANCIS INC
Publication Type:: Journal Article
Citation:: Autophagy, 2022, 18, (11), pp. 2537-2546
Issue Date:: 2022-11

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Field	Value	Language
dc.contributor.author	Don Wai Luu, L
dc.contributor.author	Kaakoush, NO
dc.contributor.author	Castaño-Rodríguez, N
dc.date.accessioned	2023-06-05T03:44:06Z
dc.date.available	2023-06-05T03:44:06Z
dc.date.issued	2022-11
dc.identifier.citation	Autophagy, 2022, 18, (11), pp. 2537-2546
dc.identifier.issn	1554-8627
dc.identifier.issn	1554-8635
dc.identifier.uri	http://hdl.handle.net/10453/170629
dc.description.abstract	Macroautophagy/autophagy, a fundamental cell process for nutrient recycling and defense against pathogens (termed xenophagy), is crucial to human health. ATG16L2 (autophagy related 16 like 2) is an autophagic protein and a paralog of ATG16L1. Both proteins are implicated in similar diseases such as cancer and other chronic diseases; however, most autophagy studies to date have primarily focused on the function of ATG16L1, with ATG16L2 remaining uncharacterized and understudied. Overexpression of ATG16L2 has been reported in various cancers including colorectal, gastric, and prostate carcinomas, whereas altered methylation of ATG16L2 has been associated with lung cancer formation and poorer response to therapy in leukemia. In addition, ATG16L2 polymorphisms have been implicated in a range of other diseases including inflammatory bowel diseases and neurodegenerative disorders. Despite this likely role in human health, the function of this enigmatic protein in autophagy remains unknown. Here, we review current studies on ATG16L2 and collate evidence that suggests that this protein is a potential modulator of autophagy as well as the implications this has on pathogenesis.Abbreviations: ATG5: autophagy related 5; ATG12: autophagy related 12; ATG16L1: autophagy related 16 like 1; ATG16L2: autophagy related 16 like 2; CD: Crohn disease; IBD: inflammatory bowel diseases; IRGM: immunity related GTPase M; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; PE: phosphatidylethanolamine; RB1CC1: RB1 inducible coiled-coil 1; SLE: systemic lupus erythematosus; WIPI2B: WD repeat domain, phosphoinositide interacting 2B.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	TAYLOR & FRANCIS INC
dc.relation.ispartof	Autophagy
dc.relation.isbasedon	10.1080/15548627.2022.2042783
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	0601 Biochemistry and Cell Biology
dc.subject.classification	Biochemistry & Molecular Biology
dc.subject.mesh	Humans
dc.subject.mesh	Autophagy
dc.subject.mesh	Autophagy-Related Proteins
dc.subject.mesh	Inflammatory Bowel Diseases
dc.subject.mesh	Neoplasms
dc.subject.mesh	Neurodegenerative Diseases
dc.subject.mesh	Humans
dc.subject.mesh	Neoplasms
dc.subject.mesh	Inflammatory Bowel Diseases
dc.subject.mesh	Neurodegenerative Diseases
dc.subject.mesh	Autophagy
dc.subject.mesh	Autophagy-Related Proteins
dc.subject.mesh	Humans
dc.subject.mesh	Autophagy
dc.subject.mesh	Autophagy-Related Proteins
dc.subject.mesh	Inflammatory Bowel Diseases
dc.subject.mesh	Neoplasms
dc.subject.mesh	Neurodegenerative Diseases
dc.title	The role of ATG16L2 in autophagy and disease.
dc.type	Journal Article
utslib.citation.volume	18
utslib.location.activity	United States
utslib.for	0601 Biochemistry and Cell Biology
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	closed_access	*
dc.date.updated	2023-06-05T03:44:02Z
pubs.issue	11
pubs.publication-status	Published
pubs.volume	18
utslib.citation.issue	11

Abstract:

Macroautophagy/autophagy, a fundamental cell process for nutrient recycling and defense against pathogens (termed xenophagy), is crucial to human health. ATG16L2 (autophagy related 16 like 2) is an autophagic protein and a paralog of ATG16L1. Both proteins are implicated in similar diseases such as cancer and other chronic diseases; however, most autophagy studies to date have primarily focused on the function of ATG16L1, with ATG16L2 remaining uncharacterized and understudied. Overexpression of ATG16L2 has been reported in various cancers including colorectal, gastric, and prostate carcinomas, whereas altered methylation of ATG16L2 has been associated with lung cancer formation and poorer response to therapy in leukemia. In addition, ATG16L2 polymorphisms have been implicated in a range of other diseases including inflammatory bowel diseases and neurodegenerative disorders. Despite this likely role in human health, the function of this enigmatic protein in autophagy remains unknown. Here, we review current studies on ATG16L2 and collate evidence that suggests that this protein is a potential modulator of autophagy as well as the implications this has on pathogenesis.Abbreviations: ATG5: autophagy related 5; ATG12: autophagy related 12; ATG16L1: autophagy related 16 like 1; ATG16L2: autophagy related 16 like 2; CD: Crohn disease; IBD: inflammatory bowel diseases; IRGM: immunity related GTPase M; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; PE: phosphatidylethanolamine; RB1CC1: RB1 inducible coiled-coil 1; SLE: systemic lupus erythematosus; WIPI2B: WD repeat domain, phosphoinositide interacting 2B.

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http://hdl.handle.net/10453/170629