Transcription-targeted gene therapy for androgen-independent prostate cancer

Nature Publishing Group
Publication Type:
Journal Article
Cancer Gene Therapy, 2002, 9 (5), pp. 443 - 452
Issue Date:
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The Escherichia coli enzyme (purine nucleoside phosphorylase, PNP) gene is delivered directly into PC3 tumors by one injection of replication-deficient human type-5 adenovirus (Ad5). Expressed PNP converts the systemically administered prodrug, 6MPDR, to
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