Genome organization and genomics in Chlamydia: whole genome sequencing increases understanding of chlamydial virulence, evolution, and phylogeny.

Luu, LDW; Kasimov, V; Phillips, S; Myers, GSA; Jelocnik, M

Genome organization and genomics in Chlamydia: whole genome sequencing increases understanding of chlamydial virulence, evolution, and phylogeny.

Luu, LDW Kasimov, V Phillips, S Myers, GSA Jelocnik, M

Permalink

Publisher:: Frontiers
Publication Type:: Journal Article
Citation:: Front Cell Infect Microbiol, 2023, 13, pp. 1178736
Issue Date:: 2023

Open Access

Copyright Clearance Process

Recently Added
In Progress
Open Access

This item is open access.

Adobe PDF

Download full textAdobe PDF (7.88 MB)

View on publisher's site

View statistics

Full metadata record

Field	Value	Language
dc.contributor.author	Luu, LDW
dc.contributor.author	Kasimov, V
dc.contributor.author	Phillips, S
dc.contributor.author	Myers, GSA
dc.contributor.author	Jelocnik, M
dc.date.accessioned	2023-07-18T14:40:46Z
dc.date.available	2023-05-10
dc.date.available	2023-07-18T14:40:46Z
dc.date.issued	2023
dc.identifier.citation	Front Cell Infect Microbiol, 2023, 13, pp. 1178736
dc.identifier.issn	2235-2988
dc.identifier.issn	2235-2988
dc.identifier.uri	http://hdl.handle.net/10453/171565
dc.description.abstract	The genus Chlamydia contains important obligate intracellular bacterial pathogens to humans and animals, including C. trachomatis and C. pneumoniae. Since 1998, when the first Chlamydia genome was published, our understanding of how these microbes interact, evolved and adapted to different intracellular host environments has been transformed due to the expansion of chlamydial genomes. This review explores the current state of knowledge in Chlamydia genomics and how whole genome sequencing has revolutionised our understanding of Chlamydia virulence, evolution, and phylogeny over the past two and a half decades. This review will also highlight developments in multi-omics and other approaches that have complemented whole genome sequencing to advance knowledge of Chlamydia pathogenesis and future directions for chlamydial genomics.
dc.format	Electronic-eCollection
dc.language	eng
dc.publisher	Frontiers
dc.relation	University of Technology Sydney
dc.relation.ispartof	Front Cell Infect Microbiol
dc.relation.isbasedon	10.3389/fcimb.2023.1178736
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	0601 Biochemistry and Cell Biology, 0605 Microbiology
dc.subject.classification	3107 Microbiology
dc.subject.classification	3207 Medical microbiology
dc.subject.mesh	Animals
dc.subject.mesh	Humans
dc.subject.mesh	Phylogeny
dc.subject.mesh	Virulence
dc.subject.mesh	Chlamydia
dc.subject.mesh	Chlamydia trachomatis
dc.subject.mesh	Chlamydia Infections
dc.subject.mesh	Genomics
dc.subject.mesh	Whole Genome Sequencing
dc.subject.mesh	Genome, Bacterial
dc.subject.mesh	Animals
dc.subject.mesh	Humans
dc.subject.mesh	Chlamydia
dc.subject.mesh	Chlamydia trachomatis
dc.subject.mesh	Chlamydia Infections
dc.subject.mesh	Genomics
dc.subject.mesh	Phylogeny
dc.subject.mesh	Virulence
dc.subject.mesh	Genome, Bacterial
dc.subject.mesh	Whole Genome Sequencing
dc.subject.mesh	Animals
dc.subject.mesh	Humans
dc.subject.mesh	Phylogeny
dc.subject.mesh	Virulence
dc.subject.mesh	Chlamydia
dc.subject.mesh	Chlamydia trachomatis
dc.subject.mesh	Chlamydia Infections
dc.subject.mesh	Genomics
dc.subject.mesh	Whole Genome Sequencing
dc.subject.mesh	Genome, Bacterial
dc.title	Genome organization and genomics in Chlamydia: whole genome sequencing increases understanding of chlamydial virulence, evolution, and phylogeny.
dc.type	Journal Article
utslib.citation.volume	13
utslib.location.activity	Switzerland
utslib.for	0601 Biochemistry and Cell Biology
utslib.for	0605 Microbiology
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	open_access	*
dc.date.updated	2023-07-18T14:40:38Z
pubs.publication-status	Published online
pubs.volume	13

Abstract:

The genus Chlamydia contains important obligate intracellular bacterial pathogens to humans and animals, including C. trachomatis and C. pneumoniae. Since 1998, when the first Chlamydia genome was published, our understanding of how these microbes interact, evolved and adapted to different intracellular host environments has been transformed due to the expansion of chlamydial genomes. This review explores the current state of knowledge in Chlamydia genomics and how whole genome sequencing has revolutionised our understanding of Chlamydia virulence, evolution, and phylogeny over the past two and a half decades. This review will also highlight developments in multi-omics and other approaches that have complemented whole genome sequencing to advance knowledge of Chlamydia pathogenesis and future directions for chlamydial genomics.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/171565