Integrative omics identifies conserved and pathogen-specific responses of sepsis-causing bacteria.
Mu, A
Klare, WP
Baines, SL
Ignatius Pang, CN
Guérillot, R
Harbison-Price, N
Keller, N
Wilksch, J
Nhu, NTK
Phan, M-D
Keller, B
Nijagal, B
Tull, D
Dayalan, S
Chua, HHC
Skoneczny, D
Koval, J
Hachani, A
Shah, AD
Neha, N
Jadhav, S
Partridge, SR
Cork, AJ
Peters, K
Bertolla, O
Brouwer, S
Hancock, SJ
Álvarez-Fraga, L
De Oliveira, DMP
Forde, B
Dale, A
Mujchariyakul, W
Walsh, CJ
Monk, I
Fitzgerald, A
Lum, M
Correa-Ospina, C
Roy Chowdhury, P
Parton, RG
De Voss, J
Beckett, J
Monty, F
McKinnon, J
Song, X
Stephen, JR
Everest, M
Bellgard, MI
Tinning, M
Leeming, M
Hocking, D
Jebeli, L
Wang, N
Ben Zakour, N
Yasar, SA
Vecchiarelli, S
Russell, T
Zaw, T
Chen, T
Teng, D
Kassir, Z
Lithgow, T
Jenney, A
Cole, JN
Nizet, V
Sorrell, TC
Peleg, AY
Paterson, DL
Beatson, SA
Wu, J
Molloy, MP
Syme, AE
Goode, RJA
Hunter, AA
Bowland, G
West, NP
Wilkins, MR
Djordjevic, SP
Davies, MR
Seemann, T
Howden, BP
Pascovici, D
Tyagi, S
Schittenhelm, RB
De Souza, DP
McConville, MJ
Iredell, JR
Cordwell, SJ
Strugnell, RA
Stinear, TP
Schembri, MA
Walker, MJ
- Publisher:
- Springer Nature
- Publication Type:
- Journal Article
- Citation:
- Nat Commun, 2023, 14, (1), pp. 1530
- Issue Date:
- 2023-03-18
Open Access
Copyright Clearance Process
- Recently Added
- In Progress
- Open Access
This item is open access.
Full metadata record
Field | Value | Language |
---|---|---|
dc.contributor.author | Mu, A | |
dc.contributor.author | Klare, WP | |
dc.contributor.author | Baines, SL | |
dc.contributor.author | Ignatius Pang, CN | |
dc.contributor.author | Guérillot, R | |
dc.contributor.author | Harbison-Price, N | |
dc.contributor.author | Keller, N | |
dc.contributor.author | Wilksch, J | |
dc.contributor.author | Nhu, NTK | |
dc.contributor.author | Phan, M-D | |
dc.contributor.author | Keller, B | |
dc.contributor.author | Nijagal, B | |
dc.contributor.author | Tull, D | |
dc.contributor.author | Dayalan, S | |
dc.contributor.author | Chua, HHC | |
dc.contributor.author | Skoneczny, D | |
dc.contributor.author | Koval, J | |
dc.contributor.author | Hachani, A | |
dc.contributor.author | Shah, AD | |
dc.contributor.author | Neha, N | |
dc.contributor.author | Jadhav, S | |
dc.contributor.author | Partridge, SR | |
dc.contributor.author | Cork, AJ | |
dc.contributor.author | Peters, K | |
dc.contributor.author | Bertolla, O | |
dc.contributor.author | Brouwer, S | |
dc.contributor.author | Hancock, SJ | |
dc.contributor.author | Álvarez-Fraga, L | |
dc.contributor.author | De Oliveira, DMP | |
dc.contributor.author | Forde, B | |
dc.contributor.author | Dale, A | |
dc.contributor.author | Mujchariyakul, W | |
dc.contributor.author | Walsh, CJ | |
dc.contributor.author | Monk, I | |
dc.contributor.author | Fitzgerald, A | |
dc.contributor.author | Lum, M | |
dc.contributor.author | Correa-Ospina, C | |
dc.contributor.author | Roy Chowdhury, P | |
dc.contributor.author | Parton, RG | |
dc.contributor.author | De Voss, J | |
dc.contributor.author | Beckett, J | |
dc.contributor.author | Monty, F | |
dc.contributor.author | McKinnon, J | |
dc.contributor.author | Song, X | |
dc.contributor.author | Stephen, JR | |
dc.contributor.author | Everest, M | |
dc.contributor.author | Bellgard, MI | |
dc.contributor.author | Tinning, M | |
dc.contributor.author | Leeming, M | |
dc.contributor.author | Hocking, D | |
dc.contributor.author | Jebeli, L | |
dc.contributor.author | Wang, N | |
dc.contributor.author | Ben Zakour, N | |
dc.contributor.author | Yasar, SA | |
dc.contributor.author | Vecchiarelli, S | |
dc.contributor.author | Russell, T | |
dc.contributor.author | Zaw, T | |
dc.contributor.author | Chen, T | |
dc.contributor.author | Teng, D | |
dc.contributor.author | Kassir, Z | |
dc.contributor.author | Lithgow, T | |
dc.contributor.author | Jenney, A | |
dc.contributor.author | Cole, JN | |
dc.contributor.author | Nizet, V | |
dc.contributor.author | Sorrell, TC | |
dc.contributor.author | Peleg, AY | |
dc.contributor.author | Paterson, DL | |
dc.contributor.author | Beatson, SA | |
dc.contributor.author | Wu, J | |
dc.contributor.author | Molloy, MP | |
dc.contributor.author | Syme, AE | |
dc.contributor.author | Goode, RJA | |
dc.contributor.author | Hunter, AA | |
dc.contributor.author | Bowland, G | |
dc.contributor.author | West, NP | |
dc.contributor.author | Wilkins, MR | |
dc.contributor.author | Djordjevic, SP | |
dc.contributor.author | Davies, MR | |
dc.contributor.author | Seemann, T | |
dc.contributor.author | Howden, BP | |
dc.contributor.author | Pascovici, D | |
dc.contributor.author | Tyagi, S | |
dc.contributor.author | Schittenhelm, RB | |
dc.contributor.author | De Souza, DP | |
dc.contributor.author | McConville, MJ | |
dc.contributor.author | Iredell, JR | |
dc.contributor.author | Cordwell, SJ | |
dc.contributor.author | Strugnell, RA | |
dc.contributor.author | Stinear, TP | |
dc.contributor.author | Schembri, MA | |
dc.contributor.author | Walker, MJ | |
dc.date.accessioned | 2023-09-29T05:34:35Z | |
dc.date.available | 2023-03-06 | |
dc.date.available | 2023-09-29T05:34:35Z | |
dc.date.issued | 2023-03-18 | |
dc.identifier.citation | Nat Commun, 2023, 14, (1), pp. 1530 | |
dc.identifier.issn | 2041-1723 | |
dc.identifier.issn | 2041-1723 | |
dc.identifier.uri | http://hdl.handle.net/10453/172388 | |
dc.description.abstract | Even in the setting of optimal resuscitation in high-income countries severe sepsis and septic shock have a mortality of 20-40%, with antibiotic resistance dramatically increasing this mortality risk. To develop a reference dataset enabling the identification of common bacterial targets for therapeutic intervention, we applied a standardized genomic, transcriptomic, proteomic and metabolomic technological framework to multiple clinical isolates of four sepsis-causing pathogens: Escherichia coli, Klebsiella pneumoniae species complex, Staphylococcus aureus and Streptococcus pyogenes. Exposure to human serum generated a sepsis molecular signature containing global increases in fatty acid and lipid biosynthesis and metabolism, consistent with cell envelope remodelling and nutrient adaptation for osmoprotection. In addition, acquisition of cholesterol was identified across the bacterial species. This detailed reference dataset has been established as an open resource to support discovery and translational research. | |
dc.format | Electronic | |
dc.language | eng | |
dc.publisher | Springer Nature | |
dc.relation.ispartof | Nat Commun | |
dc.relation.isbasedon | 10.1038/s41467-023-37200-w | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Anti-Bacterial Agents | |
dc.subject.mesh | Proteomics | |
dc.subject.mesh | Sepsis | |
dc.subject.mesh | Bacteria | |
dc.subject.mesh | Staphylococcal Infections | |
dc.subject.mesh | Escherichia coli | |
dc.subject.mesh | Klebsiella | |
dc.subject.mesh | Microbial Sensitivity Tests | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Bacteria | |
dc.subject.mesh | Escherichia coli | |
dc.subject.mesh | Klebsiella | |
dc.subject.mesh | Staphylococcal Infections | |
dc.subject.mesh | Sepsis | |
dc.subject.mesh | Anti-Bacterial Agents | |
dc.subject.mesh | Microbial Sensitivity Tests | |
dc.subject.mesh | Proteomics | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Anti-Bacterial Agents | |
dc.subject.mesh | Proteomics | |
dc.subject.mesh | Sepsis | |
dc.subject.mesh | Bacteria | |
dc.subject.mesh | Staphylococcal Infections | |
dc.subject.mesh | Escherichia coli | |
dc.subject.mesh | Klebsiella | |
dc.subject.mesh | Microbial Sensitivity Tests | |
dc.title | Integrative omics identifies conserved and pathogen-specific responses of sepsis-causing bacteria. | |
dc.type | Journal Article | |
utslib.citation.volume | 14 | |
utslib.location.activity | England | |
pubs.organisational-group | /University of Technology Sydney | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Science | |
pubs.organisational-group | /University of Technology Sydney/Strength - AIMI - Australian Institute for Microbiology & Infection | |
utslib.copyright.status | open_access | * |
dc.date.updated | 2023-09-29T05:34:29Z | |
pubs.issue | 1 | |
pubs.publication-status | Published online | |
pubs.volume | 14 | |
utslib.citation.issue | 1 |
Abstract:
Even in the setting of optimal resuscitation in high-income countries severe sepsis and septic shock have a mortality of 20-40%, with antibiotic resistance dramatically increasing this mortality risk. To develop a reference dataset enabling the identification of common bacterial targets for therapeutic intervention, we applied a standardized genomic, transcriptomic, proteomic and metabolomic technological framework to multiple clinical isolates of four sepsis-causing pathogens: Escherichia coli, Klebsiella pneumoniae species complex, Staphylococcus aureus and Streptococcus pyogenes. Exposure to human serum generated a sepsis molecular signature containing global increases in fatty acid and lipid biosynthesis and metabolism, consistent with cell envelope remodelling and nutrient adaptation for osmoprotection. In addition, acquisition of cholesterol was identified across the bacterial species. This detailed reference dataset has been established as an open resource to support discovery and translational research.
Please use this identifier to cite or link to this item:
Download statistics for the last 12 months
Not enough data to produce graph