Oxygen-vacancy-rich molybdenum carbide MXene nanonetworks for ultrasound-triggered and capturing-enhanced sonocatalytic bacteria eradication.

Zong, L; Yu, Y; Wang, J; Liu, P; Feng, W; Dai, X; Chen, L; Gunawan, C; Jimmy Yun, SL; Amal, R; Cheong, S; Gu, Z; Chen, Y

Oxygen-vacancy-rich molybdenum carbide MXene nanonetworks for ultrasound-triggered and capturing-enhanced sonocatalytic bacteria eradication.

Zong, L Yu, Y Wang, J Liu, P Feng, W Dai, X Chen, L Gunawan, C

Jimmy Yun, SL Amal, R Cheong, S Gu, Z Chen, Y

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Publisher:: Elsevier
Publication Type:: Journal Article
Citation:: Biomaterials, 2023, 296, pp. 122074
Issue Date:: 2023-05

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Field	Value	Language
dc.contributor.author	Zong, L
dc.contributor.author	Yu, Y
dc.contributor.author	Wang, J
dc.contributor.author	Liu, P
dc.contributor.author	Feng, W
dc.contributor.author	Dai, X
dc.contributor.author	Chen, L
dc.contributor.author	Gunawan, C https://orcid.org/0000-0002-2957-1347
dc.contributor.author	Jimmy Yun, SL
dc.contributor.author	Amal, R
dc.contributor.author	Cheong, S
dc.contributor.author	Gu, Z
dc.contributor.author	Chen, Y
dc.date.accessioned	2023-09-29T06:29:40Z
dc.date.available	2023-02-28
dc.date.available	2023-09-29T06:29:40Z
dc.date.issued	2023-05
dc.identifier.citation	Biomaterials, 2023, 296, pp. 122074
dc.identifier.issn	0142-9612
dc.identifier.issn	1878-5905
dc.identifier.uri	http://hdl.handle.net/10453/172393
dc.description.abstract	Incurable bacterial infection and intractable multidrug resistance remain critical challenges in public health. A prevalent approach against bacterial infection is phototherapy including photothermal and photodynamic therapy, which is unfortunately limited by low penetration depth of light accompanied with inevitable hyperthermia and phototoxicity damaging healthy tissues. Thus, eco-friendly strategy with biocompatibility and high antimicrobial efficacy against bacteria is urgently desired. Herein, we propose and develop an oxygen-vacancy-rich MoOxin situ on fluorine-free Mo2C MXene with unique neural-network-like structure, namely MoOx@Mo2C nanonetworks, in which their desirable antibacterial effectiveness originates from bacteria-capturing ability and robust reactive oxygen species (ROS) generation under precise ultrasound (US) irradiation. The high-performance, broad-spectrum microbicidal activity of MoOx@Mo2C nanonetworks without damaging normal tissues is validated based on systematic in vitro and in vivo assessments. Additionally, RNA sequencing analysis illuminates that the underlying bactericidal mechanism is attributed to the chaotic homeostasis and disruptive peptide metabolisms on bacteria instigated by MoOx@Mo2C nanonetworks under US stimulation. Considering antibacterial efficiency and a high degree of biosafety, we envision that the MoOx@Mo2C nanonetworks can serve as a distinct antimicrobial nanosystem to fight against diverse pathogenic bacteria, especially eradicating multidrug-resistant bacteria-induced deep tissue infection.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Elsevier
dc.relation.ispartof	Biomaterials
dc.relation.isbasedon	10.1016/j.biomaterials.2023.122074
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject.classification	Biomedical Engineering
dc.subject.mesh	Humans
dc.subject.mesh	Oxygen
dc.subject.mesh	Hyperthermia, Induced
dc.subject.mesh	Anti-Bacterial Agents
dc.subject.mesh	Molybdenum
dc.subject.mesh	Bacterial Infections
dc.subject.mesh	Bacteria
dc.subject.mesh	Humans
dc.subject.mesh	Bacteria
dc.subject.mesh	Bacterial Infections
dc.subject.mesh	Oxygen
dc.subject.mesh	Molybdenum
dc.subject.mesh	Anti-Bacterial Agents
dc.subject.mesh	Hyperthermia, Induced
dc.subject.mesh	Humans
dc.subject.mesh	Oxygen
dc.subject.mesh	Hyperthermia, Induced
dc.subject.mesh	Anti-Bacterial Agents
dc.subject.mesh	Molybdenum
dc.subject.mesh	Bacterial Infections
dc.subject.mesh	Bacteria
dc.title	Oxygen-vacancy-rich molybdenum carbide MXene nanonetworks for ultrasound-triggered and capturing-enhanced sonocatalytic bacteria eradication.
dc.type	Journal Article
utslib.citation.volume	296
utslib.location.activity	Netherlands
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Strength - AIMI - Australian Institute for Microbiology & Infection
utslib.copyright.status	closed_access	*
dc.date.updated	2023-09-29T06:29:36Z
pubs.publication-status	Published
pubs.volume	296

Abstract:

Incurable bacterial infection and intractable multidrug resistance remain critical challenges in public health. A prevalent approach against bacterial infection is phototherapy including photothermal and photodynamic therapy, which is unfortunately limited by low penetration depth of light accompanied with inevitable hyperthermia and phototoxicity damaging healthy tissues. Thus, eco-friendly strategy with biocompatibility and high antimicrobial efficacy against bacteria is urgently desired. Herein, we propose and develop an oxygen-vacancy-rich MoOxin situ on fluorine-free Mo2C MXene with unique neural-network-like structure, namely MoOx@Mo2C nanonetworks, in which their desirable antibacterial effectiveness originates from bacteria-capturing ability and robust reactive oxygen species (ROS) generation under precise ultrasound (US) irradiation. The high-performance, broad-spectrum microbicidal activity of MoOx@Mo2C nanonetworks without damaging normal tissues is validated based on systematic in vitro and in vivo assessments. Additionally, RNA sequencing analysis illuminates that the underlying bactericidal mechanism is attributed to the chaotic homeostasis and disruptive peptide metabolisms on bacteria instigated by MoOx@Mo2C nanonetworks under US stimulation. Considering antibacterial efficiency and a high degree of biosafety, we envision that the MoOx@Mo2C nanonetworks can serve as a distinct antimicrobial nanosystem to fight against diverse pathogenic bacteria, especially eradicating multidrug-resistant bacteria-induced deep tissue infection.

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http://hdl.handle.net/10453/172393