Squamous cell carcinoma antigen 1 is an inhibitor of parasite-derived cysteine proteases

Kanaji, S; Tanaka, Y; Sakata, Y; Takeshita, K; Arima, K; Ohta, S; Hansell, EJ; Caffrey, C; Mottram, JC; Lowther, J; Donnelly, S; Stack, C; Kadowaki, T; Yamamoto, K; McKerrow, JH; Dalton, JP; Coombs, GH; Izuhara, K

Squamous cell carcinoma antigen 1 is an inhibitor of parasite-derived cysteine proteases

Kanaji, S Tanaka, Y Sakata, Y Takeshita, K Arima, K Ohta, S Hansell, EJ Caffrey, C Mottram, JC Lowther, J Donnelly, S

Stack, C Kadowaki, T Yamamoto, K McKerrow, JH Dalton, JP Coombs, GH Izuhara, K

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Publication Type:: Journal Article
Citation:: FEBS Letters, 2007, 581 (22), pp. 4260 - 4264
Issue Date:: 2007-09-04

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Field	Value	Language
dc.contributor.author	Kanaji, S	en_US
dc.contributor.author	Tanaka, Y	en_US
dc.contributor.author	Sakata, Y	en_US
dc.contributor.author	Takeshita, K	en_US
dc.contributor.author	Arima, K	en_US
dc.contributor.author	Ohta, S	en_US
dc.contributor.author	Hansell, EJ	en_US
dc.contributor.author	Caffrey, C	en_US
dc.contributor.author	Mottram, JC	en_US
dc.contributor.author	Lowther, J	en_US
dc.contributor.author	Donnelly, S https://orcid.org/0000-0003-2005-3698	en_US
dc.contributor.author	Stack, C	en_US
dc.contributor.author	Kadowaki, T	en_US
dc.contributor.author	Yamamoto, K	en_US
dc.contributor.author	McKerrow, JH	en_US
dc.contributor.author	Dalton, JP	en_US
dc.contributor.author	Coombs, GH	en_US
dc.contributor.author	Izuhara, K	en_US
dc.date.available	2007-07-29	en_US
dc.date.issued	2007-09-04	en_US
dc.identifier.citation	FEBS Letters, 2007, 581 (22), pp. 4260 - 4264	en_US
dc.identifier.issn	0014-5793	en_US
dc.identifier.uri	http://hdl.handle.net/10453/17372
dc.description.abstract	The physiological significance of the squamous cell carcinoma antigens 1 (SCCA1) and SCCA2, members of the ovalbumin serpin family, remains unresolved. In this study, we examined whether SCCA1 or SCCA2 inhibits protozoa- or helminth-derived cysteine proteases. SCCA1, but not SCCA2, potently inhibited the cysteine protease activities of CPB2.8 from Leishmania mexicana, cruzain from Trypanosoma cruzi, rhodesain from Trypanosoma brucei rhodesience, and cathepsin L2 from Fasciola hepatica. The inhibitory activities of SCCA1 were due to its resistance to cleavage by the cysteine proteases. The findings indicate that induction of cysteine protease inhibitors might be a novel defense mechanism against parasite development. © 2007 Federation of European Biochemical Societies.	en_US
dc.relation.ispartof	FEBS Letters	en_US
dc.relation.isbasedon	10.1016/j.febslet.2007.07.072	en_US
dc.subject.classification	Biochemistry & Molecular Biology	en_US
dc.subject.mesh	Cell Line	en_US
dc.subject.mesh	Keratinocytes	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Parasites	en_US
dc.subject.mesh	Cysteine Endopeptidases	en_US
dc.subject.mesh	Serpins	en_US
dc.subject.mesh	Antigens, Neoplasm	en_US
dc.subject.mesh	Cysteine Proteinase Inhibitors	en_US
dc.subject.mesh	Amino Acid Sequence	en_US
dc.subject.mesh	Structure-Activity Relationship	en_US
dc.subject.mesh	Catalysis	en_US
dc.subject.mesh	Molecular Sequence Data	en_US
dc.title	Squamous cell carcinoma antigen 1 is an inhibitor of parasite-derived cysteine proteases	en_US
dc.type	Journal Article
utslib.citation.volume	22	en_US
utslib.citation.volume	581	en_US
utslib.for	0605 Microbiology	en_US
utslib.for	0304 Medicinal and Biomolecular Chemistry	en_US
utslib.for	0601 Biochemistry and Cell Biology	en_US
utslib.for	0603 Evolutionary Biology	en_US
dc.location.activity	ISI:000247331200007
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	closed_access
pubs.issue	22	en_US
pubs.publication-status	Published	en_US
pubs.volume	581	en_US

Abstract:

The physiological significance of the squamous cell carcinoma antigens 1 (SCCA1) and SCCA2, members of the ovalbumin serpin family, remains unresolved. In this study, we examined whether SCCA1 or SCCA2 inhibits protozoa- or helminth-derived cysteine proteases. SCCA1, but not SCCA2, potently inhibited the cysteine protease activities of CPB2.8 from Leishmania mexicana, cruzain from Trypanosoma cruzi, rhodesain from Trypanosoma brucei rhodesience, and cathepsin L2 from Fasciola hepatica. The inhibitory activities of SCCA1 were due to its resistance to cleavage by the cysteine proteases. The findings indicate that induction of cysteine protease inhibitors might be a novel defense mechanism against parasite development. © 2007 Federation of European Biochemical Societies.

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http://hdl.handle.net/10453/17372