Squamous cell carcinoma antigen 1 is an inhibitor of parasite-derived cysteine proteases
Kanaji, S
Tanaka, Y
Sakata, Y
Takeshita, K
Arima, K
Ohta, S
Hansell, EJ
Caffrey, C
Mottram, JC
Lowther, J
Donnelly, S
Stack, C
Kadowaki, T
Yamamoto, K
McKerrow, JH
Dalton, JP
Coombs, GH
Izuhara, K
- Publication Type:
- Journal Article
- Citation:
- FEBS Letters, 2007, 581 (22), pp. 4260 - 4264
- Issue Date:
- 2007-09-04
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Full metadata record
Field | Value | Language |
---|---|---|
dc.contributor.author | Kanaji, S | en_US |
dc.contributor.author | Tanaka, Y | en_US |
dc.contributor.author | Sakata, Y | en_US |
dc.contributor.author | Takeshita, K | en_US |
dc.contributor.author | Arima, K | en_US |
dc.contributor.author | Ohta, S | en_US |
dc.contributor.author | Hansell, EJ | en_US |
dc.contributor.author | Caffrey, C | en_US |
dc.contributor.author | Mottram, JC | en_US |
dc.contributor.author | Lowther, J | en_US |
dc.contributor.author |
Donnelly, S |
en_US |
dc.contributor.author | Stack, C | en_US |
dc.contributor.author | Kadowaki, T | en_US |
dc.contributor.author | Yamamoto, K | en_US |
dc.contributor.author | McKerrow, JH | en_US |
dc.contributor.author | Dalton, JP | en_US |
dc.contributor.author | Coombs, GH | en_US |
dc.contributor.author | Izuhara, K | en_US |
dc.date.available | 2007-07-29 | en_US |
dc.date.issued | 2007-09-04 | en_US |
dc.identifier.citation | FEBS Letters, 2007, 581 (22), pp. 4260 - 4264 | en_US |
dc.identifier.issn | 0014-5793 | en_US |
dc.identifier.uri | http://hdl.handle.net/10453/17372 | |
dc.description.abstract | The physiological significance of the squamous cell carcinoma antigens 1 (SCCA1) and SCCA2, members of the ovalbumin serpin family, remains unresolved. In this study, we examined whether SCCA1 or SCCA2 inhibits protozoa- or helminth-derived cysteine proteases. SCCA1, but not SCCA2, potently inhibited the cysteine protease activities of CPB2.8 from Leishmania mexicana, cruzain from Trypanosoma cruzi, rhodesain from Trypanosoma brucei rhodesience, and cathepsin L2 from Fasciola hepatica. The inhibitory activities of SCCA1 were due to its resistance to cleavage by the cysteine proteases. The findings indicate that induction of cysteine protease inhibitors might be a novel defense mechanism against parasite development. © 2007 Federation of European Biochemical Societies. | en_US |
dc.relation.ispartof | FEBS Letters | en_US |
dc.relation.isbasedon | 10.1016/j.febslet.2007.07.072 | en_US |
dc.subject.classification | Biochemistry & Molecular Biology | en_US |
dc.subject.mesh | Cell Line | en_US |
dc.subject.mesh | Keratinocytes | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Parasites | en_US |
dc.subject.mesh | Cysteine Endopeptidases | en_US |
dc.subject.mesh | Serpins | en_US |
dc.subject.mesh | Antigens, Neoplasm | en_US |
dc.subject.mesh | Cysteine Proteinase Inhibitors | en_US |
dc.subject.mesh | Amino Acid Sequence | en_US |
dc.subject.mesh | Structure-Activity Relationship | en_US |
dc.subject.mesh | Catalysis | en_US |
dc.subject.mesh | Molecular Sequence Data | en_US |
dc.title | Squamous cell carcinoma antigen 1 is an inhibitor of parasite-derived cysteine proteases | en_US |
dc.type | Journal Article | |
utslib.citation.volume | 22 | en_US |
utslib.citation.volume | 581 | en_US |
utslib.for | 0605 Microbiology | en_US |
utslib.for | 0304 Medicinal and Biomolecular Chemistry | en_US |
utslib.for | 0601 Biochemistry and Cell Biology | en_US |
utslib.for | 0603 Evolutionary Biology | en_US |
dc.location.activity | ISI:000247331200007 | |
pubs.embargo.period | Not known | en_US |
pubs.organisational-group | /University of Technology Sydney | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Science | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Science/School of Life Sciences | |
utslib.copyright.status | closed_access | |
pubs.issue | 22 | en_US |
pubs.publication-status | Published | en_US |
pubs.volume | 581 | en_US |
Abstract:
The physiological significance of the squamous cell carcinoma antigens 1 (SCCA1) and SCCA2, members of the ovalbumin serpin family, remains unresolved. In this study, we examined whether SCCA1 or SCCA2 inhibits protozoa- or helminth-derived cysteine proteases. SCCA1, but not SCCA2, potently inhibited the cysteine protease activities of CPB2.8 from Leishmania mexicana, cruzain from Trypanosoma cruzi, rhodesain from Trypanosoma brucei rhodesience, and cathepsin L2 from Fasciola hepatica. The inhibitory activities of SCCA1 were due to its resistance to cleavage by the cysteine proteases. The findings indicate that induction of cysteine protease inhibitors might be a novel defense mechanism against parasite development. © 2007 Federation of European Biochemical Societies.
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