Striatal Acetylcholine and Dopamine Interactions Produce Situation-appropriate Action Selection.

Bradfield, LA; Becchi, S; Kendig, MD

Striatal Acetylcholine and Dopamine Interactions Produce Situation-appropriate Action Selection.

Bradfield, LA Becchi, S Kendig, MD

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Publisher:: Bentham Science Publishers
Publication Type:: Journal Article
Citation:: Curr Neuropharmacol, 2023, 21
Issue Date:: 2023-09-13

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Field	Value	Language
dc.contributor.author	Bradfield, LA
dc.contributor.author	Becchi, S
dc.contributor.author	Kendig, MD
dc.date.accessioned	2024-01-03T01:17:52Z
dc.date.available	2023-03-29
dc.date.available	2024-01-03T01:17:52Z
dc.date.issued	2023-09-13
dc.identifier.citation	Curr Neuropharmacol, 2023, 21
dc.identifier.issn	1570-159X
dc.identifier.issn	1875-6190
dc.identifier.uri	http://hdl.handle.net/10453/173939
dc.description.abstract	Individuals often learn how to perform new actions for particular outcomes against a complex background of existing action-outcome associations. As such, this new knowledge can interfere or even compete with existing knowledge, such that individuals must use internal and external cues to determine which action is appropriate to the current situation. The question thus remains as to how this problem is solved at a neural level. Research over the last decade or so has begun to determine how the brain achieves situation-appropriate action selection. Several converging lines of evidence suggest that it is achieved through the complex interactions of acetylcholine and dopamine within the striatum in a manner that relies on glutamatergic inputs from the cortex and thalamus. Here we briefly review this evidence, then relate it to several very recent findings to provide new, speculative insights regarding the precise nature of striatal acetylcholine/dopamine interaction dynamics and their relation to situation- appropriate action selection.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Bentham Science Publishers
dc.relation	http://purl.org/au-research/grants/arc/DP200102445
dc.relation	http://purl.org/au-research/grants/nhmrc/2003346
dc.relation.ispartof	Curr Neuropharmacol
dc.relation.isbasedon	10.2174/1570159X21666230912093041
dc.rights	info:eu-repo/semantics/embargoedAccess
dc.subject	1109 Neurosciences, 1115 Pharmacology and Pharmaceutical Sciences, 1701 Psychology
dc.subject.classification	Neurology & Neurosurgery
dc.subject.classification	3209 Neurosciences
dc.subject.classification	3214 Pharmacology and pharmaceutical sciences
dc.subject.classification	5202 Biological psychology
dc.title	Striatal Acetylcholine and Dopamine Interactions Produce Situation-appropriate Action Selection.
dc.type	Journal Article
utslib.citation.volume	21
utslib.location.activity	United Arab Emirates
utslib.for	1109 Neurosciences
utslib.for	1115 Pharmacology and Pharmaceutical Sciences
utslib.for	1701 Psychology
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	open_access	*
utslib.copyright.embargo	2024-09-13T00:00:00+1000Z
dc.date.updated	2024-01-03T01:17:51Z
pubs.publication-status	Published online
pubs.volume	21

Abstract:

Individuals often learn how to perform new actions for particular outcomes against a complex background of existing action-outcome associations. As such, this new knowledge can interfere or even compete with existing knowledge, such that individuals must use internal and external cues to determine which action is appropriate to the current situation. The question thus remains as to how this problem is solved at a neural level. Research over the last decade or so has begun to determine how the brain achieves situation-appropriate action selection. Several converging lines of evidence suggest that it is achieved through the complex interactions of acetylcholine and dopamine within the striatum in a manner that relies on glutamatergic inputs from the cortex and thalamus. Here we briefly review this evidence, then relate it to several very recent findings to provide new, speculative insights regarding the precise nature of striatal acetylcholine/dopamine interaction dynamics and their relation to situation- appropriate action selection.

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http://hdl.handle.net/10453/173939