Host-Derived Extracellular Vesicles in Blood and Tissue Human Protozoan Infections.

Tiberti, N; Longoni, SS; Combes, V; Piubelli, C

Host-Derived Extracellular Vesicles in Blood and Tissue Human Protozoan Infections.

Tiberti, N Longoni, SS Combes, V

Piubelli, C

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Publisher:: MDPI
Publication Type:: Journal Article
Citation:: Microorganisms, 2023, 11, (9), pp. 2318
Issue Date:: 2023-09-14

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Field	Value	Language
dc.contributor.author	Tiberti, N
dc.contributor.author	Longoni, SS
dc.contributor.author	Combes, V https://orcid.org/0000-0003-2178-3596
dc.contributor.author	Piubelli, C
dc.date.accessioned	2024-01-16T00:24:56Z
dc.date.available	2023-09-11
dc.date.available	2024-01-16T00:24:56Z
dc.date.issued	2023-09-14
dc.identifier.citation	Microorganisms, 2023, 11, (9), pp. 2318
dc.identifier.issn	2076-2607
dc.identifier.issn	2076-2607
dc.identifier.uri	http://hdl.handle.net/10453/174512
dc.description.abstract	Blood and tissue protozoan infections are responsible for an enormous burden in tropical and subtropical regions, even though they can also affect people living in high-income countries, mainly as a consequence of migration and travel. These pathologies are responsible for heavy socio-economic issues in endemic countries, where the lack of proper therapeutic interventions and effective vaccine strategies is still hampering their control. Moreover, the pathophysiological mechanisms associated with the establishment, progression and outcome of these infectious diseases are yet to be fully described. Among all the players, extracellular vesicles (EVs) have raised significant interest during the last decades due to their capacity to modulate inter-parasite and host-parasite interactions. In the present manuscript, we will review the state of the art of circulating host-derived EVs in clinical samples or in experimental models of human blood and tissue protozoan diseases (i.e., malaria, leishmaniasis, Chagas disease, human African trypanosomiasis and toxoplasmosis) to gain novel insights into the mechanisms of pathology underlying these conditions and to identify novel potential diagnostic markers.
dc.format	Electronic
dc.language	eng
dc.publisher	MDPI
dc.relation.ispartof	Microorganisms
dc.relation.isbasedon	10.3390/microorganisms11092318
dc.rights	info:eu-repo/semantics/openAccess
dc.subject.classification	3107 Microbiology
dc.subject.classification	3207 Medical microbiology
dc.title	Host-Derived Extracellular Vesicles in Blood and Tissue Human Protozoan Infections.
dc.type	Journal Article
utslib.citation.volume	11
utslib.location.activity	Switzerland
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	open_access	*
dc.date.updated	2024-01-16T00:24:52Z
pubs.issue	9
pubs.publication-status	Published online
pubs.volume	11
utslib.citation.issue	9

Abstract:

Blood and tissue protozoan infections are responsible for an enormous burden in tropical and subtropical regions, even though they can also affect people living in high-income countries, mainly as a consequence of migration and travel. These pathologies are responsible for heavy socio-economic issues in endemic countries, where the lack of proper therapeutic interventions and effective vaccine strategies is still hampering their control. Moreover, the pathophysiological mechanisms associated with the establishment, progression and outcome of these infectious diseases are yet to be fully described. Among all the players, extracellular vesicles (EVs) have raised significant interest during the last decades due to their capacity to modulate inter-parasite and host-parasite interactions. In the present manuscript, we will review the state of the art of circulating host-derived EVs in clinical samples or in experimental models of human blood and tissue protozoan diseases (i.e., malaria, leishmaniasis, Chagas disease, human African trypanosomiasis and toxoplasmosis) to gain novel insights into the mechanisms of pathology underlying these conditions and to identify novel potential diagnostic markers.

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http://hdl.handle.net/10453/174512