Extracellular Matrix Protein-1 as a Mediator of Inflammation-Induced Fibrosis After Myocardial Infarction.

Hardy, SA; Liesinger, L; Patrick, R; Poettler, M; Rech, L; Gindlhuber, J; Mabotuwana, NS; Ashour, D; Stangl, V; Bigland, M; Murtha, LA; Starkey, MR; Scherr, D; Hansbro, PM; Hoefler, G; Campos Ramos, G; Cochain, C; Harvey, RP; Birner-Gruenberger, R; Boyle, AJ; Rainer, PP

Extracellular Matrix Protein-1 as a Mediator of Inflammation-Induced Fibrosis After Myocardial Infarction.

Hardy, SA Liesinger, L Patrick, R Poettler, M Rech, L Gindlhuber, J Mabotuwana, NS Ashour, D Stangl, V Bigland, M Murtha, LA Starkey, MR Scherr, D Hansbro, PM Hoefler, G Campos Ramos, G Cochain, C Harvey, RP Birner-Gruenberger, R Boyle, AJ Rainer, PP

Permalink

Publisher:: Elsevier
Publication Type:: Journal Article
Citation:: JACC Basic Transl Sci, 2023, 8, (12), pp. 1539-1554
Issue Date:: 2023-12

Open Access

Copyright Clearance Process

Recently Added
In Progress
Open Access

This item is open access.

Download Published versionAdobe PDF (3.64 MB)

View on publisher's site

View statistics

Full metadata record

Field	Value	Language
dc.contributor.author	Hardy, SA
dc.contributor.author	Liesinger, L
dc.contributor.author	Patrick, R
dc.contributor.author	Poettler, M
dc.contributor.author	Rech, L
dc.contributor.author	Gindlhuber, J
dc.contributor.author	Mabotuwana, NS
dc.contributor.author	Ashour, D
dc.contributor.author	Stangl, V
dc.contributor.author	Bigland, M
dc.contributor.author	Murtha, LA
dc.contributor.author	Starkey, MR
dc.contributor.author	Scherr, D
dc.contributor.author	Hansbro, PM
dc.contributor.author	Hoefler, G
dc.contributor.author	Campos Ramos, G
dc.contributor.author	Cochain, C
dc.contributor.author	Harvey, RP
dc.contributor.author	Birner-Gruenberger, R
dc.contributor.author	Boyle, AJ
dc.contributor.author	Rainer, PP
dc.date.accessioned	2024-01-25T05:28:31Z
dc.date.available	2023-05-17
dc.date.available	2024-01-25T05:28:31Z
dc.date.issued	2023-12
dc.identifier.citation	JACC Basic Transl Sci, 2023, 8, (12), pp. 1539-1554
dc.identifier.issn	2452-302X
dc.identifier.issn	2452-302X
dc.identifier.uri	http://hdl.handle.net/10453/174945
dc.description.abstract	Irreversible fibrosis is a hallmark of myocardial infarction (MI) and heart failure. Extracellular matrix protein-1 (ECM-1) is up-regulated in these hearts, localized to fibrotic, inflammatory, and perivascular areas. ECM-1 originates predominantly from fibroblasts, macrophages, and pericytes/vascular cells in uninjured human and mouse hearts, and from M1 and M2 macrophages and myofibroblasts after MI. ECM-1 stimulates fibroblast-to-myofibroblast transition, up-regulates key fibrotic and inflammatory pathways, and inhibits cardiac fibroblast migration. ECM-1 binds HuCFb cell surface receptor LRP1, and LRP1 inhibition blocks ECM-1 from stimulating fibroblast-to-myofibroblast transition, confirming a novel ECM-1-LRP1 fibrotic signaling axis. ECM-1 may represent a novel mechanism facilitating inflammation-fibrosis crosstalk.
dc.format	Electronic-eCollection
dc.language	eng
dc.publisher	Elsevier
dc.relation	http://purl.org/au-research/grants/nhmrc/GNT1079187
dc.relation	http://purl.org/au-research/grants/nhmrc/1175134
dc.relation	http://purl.org/au-research/grants/nhmrc/1074386
dc.relation.ispartof	JACC Basic Transl Sci
dc.relation.isbasedon	10.1016/j.jacbts.2023.05.010
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	1102 Cardiorespiratory Medicine and Haematology, 1103 Clinical Sciences
dc.subject.classification	3201 Cardiovascular medicine and haematology
dc.title	Extracellular Matrix Protein-1 as a Mediator of Inflammation-Induced Fibrosis After Myocardial Infarction.
dc.type	Journal Article
utslib.citation.volume	8
utslib.location.activity	United States
utslib.for	1102 Cardiorespiratory Medicine and Haematology
utslib.for	1103 Clinical Sciences
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Science
pubs.organisational-group	University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	University of Technology Sydney/Strength - CFI - Centre for Inflammation
utslib.copyright.status	open_access	*
dc.date.updated	2024-01-25T05:28:25Z
pubs.issue	12
pubs.publication-status	Published online
pubs.volume	8
utslib.citation.issue	12

Abstract:

Irreversible fibrosis is a hallmark of myocardial infarction (MI) and heart failure. Extracellular matrix protein-1 (ECM-1) is up-regulated in these hearts, localized to fibrotic, inflammatory, and perivascular areas. ECM-1 originates predominantly from fibroblasts, macrophages, and pericytes/vascular cells in uninjured human and mouse hearts, and from M1 and M2 macrophages and myofibroblasts after MI. ECM-1 stimulates fibroblast-to-myofibroblast transition, up-regulates key fibrotic and inflammatory pathways, and inhibits cardiac fibroblast migration. ECM-1 binds HuCFb cell surface receptor LRP1, and LRP1 inhibition blocks ECM-1 from stimulating fibroblast-to-myofibroblast transition, confirming a novel ECM-1-LRP1 fibrotic signaling axis. ECM-1 may represent a novel mechanism facilitating inflammation-fibrosis crosstalk.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/174945