On-Chip Mirror Enhanced Multiphoton Upconversion Super-Resolution Microscopy.
- Publisher:
- AMER CHEMICAL SOC
- Publication Type:
- Journal Article
- Citation:
- Nano Lett, 2023, 23, (12), pp. 5514-5519
- Issue Date:
- 2023-06-28
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| Filename | Description | Size | |||
|---|---|---|---|---|---|
| liu-et-al-2023-on-chip-mirror-enhanced-multiphoton-upconversion-super-resolution-microscopy.pdf | Published version | 3.92 MB |
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Multiphoton upconversion super-resolution microscopy (MPUM) is a promising imaging modality, which can provide increased resolution and penetration depth by using nonlinear near-infrared emission light through the so-called transparent biological window. However, a high excitation power is needed to achieve emission saturation, which increases phototoxicity. Here, we present an approach to realize the nonlinear saturation emission under a low excitation power by a simply designed on-chip mirror. The interference of the local electromagnetic field can easily confine the point spread function to a specific area to increase the excitation efficiency, which enables emission saturation under a lower excitation power. With no additional complexity, the mirror assists to decrease the excitation power by 10-fold and facilities the achievement of a lateral resolution around 35 nm, 1/28th of the excitation wavelength, in imaging of a single nanoparticle on-chip. This method offers a simple solution for super-resolution enhancement by a predesigned on-chip device.
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