Single-particle photoacoustic vibrational spectroscopy using optical microresonators

Tang, SJ; Zhang, M; Sun, J; Meng, JW; Xiong, X; Gong, Q; Jin, D; Yang, QF; Xiao, YF

Single-particle photoacoustic vibrational spectroscopy using optical microresonators

Tang, SJ Zhang, M Sun, J Meng, JW Xiong, X Gong, Q Jin, D

Yang, QF Xiao, YF

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Publisher:: NATURE PORTFOLIO
Publication Type:: Journal Article
Citation:: Nature Photonics, 2023, 17, (11), pp. 951-956
Issue Date:: 2023-11-01

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Field	Value	Language
dc.contributor.author	Tang, SJ
dc.contributor.author	Zhang, M
dc.contributor.author	Sun, J
dc.contributor.author	Meng, JW
dc.contributor.author	Xiong, X
dc.contributor.author	Gong, Q
dc.contributor.author	Jin, D https://orcid.org/0000-0003-1046-2666
dc.contributor.author	Yang, QF
dc.contributor.author	Xiao, YF
dc.date.accessioned	2024-02-09T00:17:26Z
dc.date.available	2024-02-09T00:17:26Z
dc.date.issued	2023-11-01
dc.identifier.citation	Nature Photonics, 2023, 17, (11), pp. 951-956
dc.identifier.issn	1749-4885
dc.identifier.issn	1749-4893
dc.identifier.uri	http://hdl.handle.net/10453/175530
dc.description.abstract	Vibrational spectroscopy is a ubiquitous technology that derives the species, constituents and morphology of an object from its natural vibrations. However, natural vibrations of mesoscopic particles—including most biological cells—have remained hidden from existing technologies. These particles are expected to vibrate faintly at megahertz to gigahertz rates, requiring a sensitivity and resolution that are impractical for current optical and piezoelectric spectroscopies. Here we demonstrate the real-time measurement of natural vibrations of single mesoscopic particles using an optical microresonator, extending the reach of vibrational spectroscopy to a different spectral window. Conceptually, a spectrum of vibrational modes of the particles is stimulated photoacoustically by the absorption of laser pulses and acoustically coupled to a high-quality-factor optical resonance for ultrasensitive readout. Experimentally, this scheme is verified by measuring mesoscopic particles with different constituents, sizes and internal structures, showing an unprecedented signal-to-noise ratio of 50 dB and detection bandwidth of over 1 GHz. This technology is further applied for the biomechanical fingerprinting of the species and living states of microorganisms at the single-cell level. This work opens up new avenues to study single-particle mechanical properties in vibrational degrees of freedom and may find applications in photoacoustic sensing and imaging, cavity optomechanics and biomechanics.
dc.language	English
dc.publisher	NATURE PORTFOLIO
dc.relation.ispartof	Nature Photonics
dc.relation.isbasedon	10.1038/s41566-023-01264-3
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	01 Mathematical Sciences, 02 Physical Sciences
dc.subject.classification	Optoelectronics & Photonics
dc.subject.classification	49 Mathematical sciences
dc.subject.classification	51 Physical sciences
dc.title	Single-particle photoacoustic vibrational spectroscopy using optical microresonators
dc.type	Journal Article
utslib.citation.volume	17
utslib.for	01 Mathematical Sciences
utslib.for	02 Physical Sciences
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Science
pubs.organisational-group	University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	University of Technology Sydney/Strength - IBMD - Initiative for Biomedical Devices
utslib.copyright.status	closed_access	*
dc.date.updated	2024-02-09T00:17:24Z
pubs.issue	11
pubs.publication-status	Published
pubs.volume	17
utslib.citation.issue	11

Abstract:

Vibrational spectroscopy is a ubiquitous technology that derives the species, constituents and morphology of an object from its natural vibrations. However, natural vibrations of mesoscopic particles—including most biological cells—have remained hidden from existing technologies. These particles are expected to vibrate faintly at megahertz to gigahertz rates, requiring a sensitivity and resolution that are impractical for current optical and piezoelectric spectroscopies. Here we demonstrate the real-time measurement of natural vibrations of single mesoscopic particles using an optical microresonator, extending the reach of vibrational spectroscopy to a different spectral window. Conceptually, a spectrum of vibrational modes of the particles is stimulated photoacoustically by the absorption of laser pulses and acoustically coupled to a high-quality-factor optical resonance for ultrasensitive readout. Experimentally, this scheme is verified by measuring mesoscopic particles with different constituents, sizes and internal structures, showing an unprecedented signal-to-noise ratio of 50 dB and detection bandwidth of over 1 GHz. This technology is further applied for the biomechanical fingerprinting of the species and living states of microorganisms at the single-cell level. This work opens up new avenues to study single-particle mechanical properties in vibrational degrees of freedom and may find applications in photoacoustic sensing and imaging, cavity optomechanics and biomechanics.

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http://hdl.handle.net/10453/175530