Bone disease imaging through the near-infrared-II window.

Mi, C; Zhang, X; Yang, C; Wu, J; Chen, X; Ma, C; Wu, S; Yang, Z; Qiao, P; Liu, Y; Wu, W; Guo, Z; Liao, J; Zhou, J; Guan, M; Liang, C; Liu, C; Jin, D

Bone disease imaging through the near-infrared-II window.

Mi, C Zhang, X Yang, C Wu, J Chen, X Ma, C Wu, S Yang, Z Qiao, P Liu, Y Wu, W Guo, Z Liao, J

Zhou, J

Guan, M Liang, C Liu, C Jin, D

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Publisher:: NATURE PORTFOLIO
Publication Type:: Journal Article
Citation:: Nat Commun, 2023, 14, (1), pp. 6287
Issue Date:: 2023-10-09

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Field	Value	Language
dc.contributor.author	Mi, C
dc.contributor.author	Zhang, X
dc.contributor.author	Yang, C
dc.contributor.author	Wu, J
dc.contributor.author	Chen, X
dc.contributor.author	Ma, C
dc.contributor.author	Wu, S
dc.contributor.author	Yang, Z
dc.contributor.author	Qiao, P
dc.contributor.author	Liu, Y
dc.contributor.author	Wu, W
dc.contributor.author	Guo, Z
dc.contributor.author	Liao, J https://orcid.org/0000-0003-0616-4762
dc.contributor.author	Zhou, J https://orcid.org/0000-0002-0605-5745
dc.contributor.author	Guan, M
dc.contributor.author	Liang, C
dc.contributor.author	Liu, C
dc.contributor.author	Jin, D https://orcid.org/0000-0003-1046-2666
dc.date.accessioned	2024-02-09T01:09:48Z
dc.date.available	2023-09-26
dc.date.available	2024-02-09T01:09:48Z
dc.date.issued	2023-10-09
dc.identifier.citation	Nat Commun, 2023, 14, (1), pp. 6287
dc.identifier.issn	2041-1723
dc.identifier.issn	2041-1723
dc.identifier.uri	http://hdl.handle.net/10453/175533
dc.description.abstract	Skeletal disorders are commonly diagnosed by X-ray imaging, but the radiation limits its use. Optical imaging through the near-infrared-II window (NIR-II, 1000-1700 nm) can penetrate deep tissues without radiation risk, but the targeting of contrast agent is non-specific. Here, we report that lanthanide-doped nanocrystals can passively target the bone marrow, which can be effective for over two months. We therefore develop the high-resolution NIR-II imaging method for bone disease diagnosis, including the 3D bone imaging instrumentation to show the intravital bone morphology. We demonstrate the monitoring of 1 mm bone defects with spatial resolution comparable to the X-ray imaging result. Moreover, NIR-II imaging can reveal the early onset inflammation as the synovitis in the early stage of rheumatoid arthritis, comparable to micro computed tomography (μCT) in diagnosis of osteoarthritis, including the symptoms of osteophyte and hyperostosis in the knee joint.
dc.format	Electronic
dc.language	eng
dc.publisher	NATURE PORTFOLIO
dc.relation.ispartof	Nat Commun
dc.relation.isbasedon	10.1038/s41467-023-42001-2
dc.rights	info:eu-repo/semantics/openAccess
dc.subject.mesh	Humans
dc.subject.mesh	X-Ray Microtomography
dc.subject.mesh	Bone Diseases
dc.subject.mesh	Bone and Bones
dc.subject.mesh	Osteoarthritis
dc.subject.mesh	Lanthanoid Series Elements
dc.subject.mesh	Optical Imaging
dc.subject.mesh	Bone and Bones
dc.subject.mesh	Humans
dc.subject.mesh	Bone Diseases
dc.subject.mesh	Osteoarthritis
dc.subject.mesh	Lanthanoid Series Elements
dc.subject.mesh	X-Ray Microtomography
dc.subject.mesh	Optical Imaging
dc.subject.mesh	Humans
dc.subject.mesh	X-Ray Microtomography
dc.subject.mesh	Bone Diseases
dc.subject.mesh	Bone and Bones
dc.subject.mesh	Osteoarthritis
dc.subject.mesh	Lanthanoid Series Elements
dc.subject.mesh	Optical Imaging
dc.title	Bone disease imaging through the near-infrared-II window.
dc.type	Journal Article
utslib.citation.volume	14
utslib.location.activity	England
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	University of Technology Sydney/Faculty of Science
pubs.organisational-group	University of Technology Sydney/Students
pubs.organisational-group	University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	University of Technology Sydney/Strength - IBMD - Initiative for Biomedical Devices
utslib.copyright.status	open_access	*
dc.date.updated	2024-02-09T01:09:43Z
pubs.issue	1
pubs.publication-status	Published online
pubs.volume	14
utslib.citation.issue	1

Abstract:

Skeletal disorders are commonly diagnosed by X-ray imaging, but the radiation limits its use. Optical imaging through the near-infrared-II window (NIR-II, 1000-1700 nm) can penetrate deep tissues without radiation risk, but the targeting of contrast agent is non-specific. Here, we report that lanthanide-doped nanocrystals can passively target the bone marrow, which can be effective for over two months. We therefore develop the high-resolution NIR-II imaging method for bone disease diagnosis, including the 3D bone imaging instrumentation to show the intravital bone morphology. We demonstrate the monitoring of 1 mm bone defects with spatial resolution comparable to the X-ray imaging result. Moreover, NIR-II imaging can reveal the early onset inflammation as the synovitis in the early stage of rheumatoid arthritis, comparable to micro computed tomography (μCT) in diagnosis of osteoarthritis, including the symptoms of osteophyte and hyperostosis in the knee joint.

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http://hdl.handle.net/10453/175533