Heterostructures with Built-in Electric Fields for Long-lasting Chemodynamic Therapy.
- Publisher:
- WILEY-V C H VERLAG GMBH
- Publication Type:
- Journal Article
- Citation:
- Angew Chem Int Ed Engl, 2023, 62, (15), pp. e202300356
- Issue Date:
- 2023-04-03
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Filename | Description | Size | |||
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Angew Chem Int Ed - 2023 - Zhang - Heterostructures with Built‐in Electric Fields for Long‐lasting Chemodynamic Therapy.pdf | Published version | 4.9 MB | Adobe PDF |
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Full metadata record
Field | Value | Language |
---|---|---|
dc.contributor.author | Zhang, H | |
dc.contributor.author | Chen, Y | |
dc.contributor.author | Hua, W | |
dc.contributor.author | Gu, W | |
dc.contributor.author | Zhuang, H | |
dc.contributor.author | Li, H | |
dc.contributor.author | Jiang, X | |
dc.contributor.author | Mao, Y | |
dc.contributor.author | Liu, Y | |
dc.contributor.author |
Jin, D https://orcid.org/0000-0003-1046-2666 |
|
dc.contributor.author | Bu, W | |
dc.date.accessioned | 2024-02-09T02:54:08Z | |
dc.date.available | 2024-02-09T02:54:08Z | |
dc.date.issued | 2023-04-03 | |
dc.identifier.citation | Angew Chem Int Ed Engl, 2023, 62, (15), pp. e202300356 | |
dc.identifier.issn | 1433-7851 | |
dc.identifier.issn | 1521-3773 | |
dc.identifier.uri | http://hdl.handle.net/10453/175542 | |
dc.description.abstract | Sustained signal activation by hydroxyl radicals (⋅OH) has great significance, especially for tumor treatment, but remains challenging. Here, a built-in electric field (BIEF)-driven strategy was proposed for sustainable generation of ⋅OH, thereby achieving long-lasting chemodynamic therapy (LCDT). As a proof of concept, a novel Janus-like Fe@Fe3 O4 -Cu2 O heterogeneous catalyst was designed and synthesized, in which the BIEF induced the transfer of electrons in the Fe core to the surface, reducing ≡Cu2+ to ≡Cu+ , thus achieving continuous Fenton-like reactions and ⋅OH release for over 18 h, which is approximately 12 times longer than that of Fe3 O4 -Cu2 O and 72 times longer than that of Cu2 O nanoparticles. In vitro and in vivo antitumor results indicated that sustained ⋅OH levels led to persistent extracellular regulated protein kinases (ERK) signal activation and irreparable oxidative damage to tumor cells, which promoted irreversible tumor apoptosis. Importantly, this strategy provides ideas for developing long-acting nanoplatforms for various applications. | |
dc.format | Print-Electronic | |
dc.language | eng | |
dc.publisher | WILEY-V C H VERLAG GMBH | |
dc.relation.ispartof | Angew Chem Int Ed Engl | |
dc.relation.isbasedon | 10.1002/anie.202300356 | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject | 03 Chemical Sciences | |
dc.subject.classification | Organic Chemistry | |
dc.subject.classification | 34 Chemical sciences | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Neoplasms | |
dc.subject.mesh | Nanoparticles | |
dc.subject.mesh | Hydroxyl Radical | |
dc.subject.mesh | Oxidative Stress | |
dc.subject.mesh | Hydrogen Peroxide | |
dc.subject.mesh | Cell Line, Tumor | |
dc.subject.mesh | Cell Line, Tumor | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Neoplasms | |
dc.subject.mesh | Hydroxyl Radical | |
dc.subject.mesh | Hydrogen Peroxide | |
dc.subject.mesh | Oxidative Stress | |
dc.subject.mesh | Nanoparticles | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Neoplasms | |
dc.subject.mesh | Nanoparticles | |
dc.subject.mesh | Hydroxyl Radical | |
dc.subject.mesh | Oxidative Stress | |
dc.subject.mesh | Hydrogen Peroxide | |
dc.subject.mesh | Cell Line, Tumor | |
dc.title | Heterostructures with Built-in Electric Fields for Long-lasting Chemodynamic Therapy. | |
dc.type | Journal Article | |
utslib.citation.volume | 62 | |
utslib.location.activity | Germany | |
utslib.for | 03 Chemical Sciences | |
pubs.organisational-group | University of Technology Sydney | |
pubs.organisational-group | University of Technology Sydney/Faculty of Design, Architecture and Building | |
pubs.organisational-group | University of Technology Sydney/Faculty of Science | |
pubs.organisational-group | University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences | |
pubs.organisational-group | University of Technology Sydney/Strength - IBMD - Initiative for Biomedical Devices | |
utslib.copyright.status | closed_access | * |
dc.date.updated | 2024-02-09T02:54:06Z | |
pubs.issue | 15 | |
pubs.publication-status | Published | |
pubs.volume | 62 | |
utslib.citation.issue | 15 |
Abstract:
Sustained signal activation by hydroxyl radicals (⋅OH) has great significance, especially for tumor treatment, but remains challenging. Here, a built-in electric field (BIEF)-driven strategy was proposed for sustainable generation of ⋅OH, thereby achieving long-lasting chemodynamic therapy (LCDT). As a proof of concept, a novel Janus-like Fe@Fe3 O4 -Cu2 O heterogeneous catalyst was designed and synthesized, in which the BIEF induced the transfer of electrons in the Fe core to the surface, reducing ≡Cu2+ to ≡Cu+ , thus achieving continuous Fenton-like reactions and ⋅OH release for over 18 h, which is approximately 12 times longer than that of Fe3 O4 -Cu2 O and 72 times longer than that of Cu2 O nanoparticles. In vitro and in vivo antitumor results indicated that sustained ⋅OH levels led to persistent extracellular regulated protein kinases (ERK) signal activation and irreparable oxidative damage to tumor cells, which promoted irreversible tumor apoptosis. Importantly, this strategy provides ideas for developing long-acting nanoplatforms for various applications.
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