MXene: An efficient hemoperfusion sorbent for the removal of uremic toxins

Wang, T; Gu, W; Yu, L; Guo, X; Yang, J; Sun, X; Guan, J; Zhou, L; Wang, C; Yao, H; Zhang, X; Wang, G

MXene: An efficient hemoperfusion sorbent for the removal of uremic toxins

Wang, T Gu, W Yu, L Guo, X

Yang, J Sun, X Guan, J Zhou, L Wang, C Yao, H Zhang, X Wang, G

Permalink

Publisher:: ELSEVIER
Publication Type:: Journal Article
Citation:: Journal of Materiomics, 2023, 9, (6), pp. 1129-1140
Issue Date:: 2023-11-01

Open Access

Copyright Clearance Process

Recently Added
In Progress
Open Access

This item is open access.

Adobe PDF

Download Published versionAdobe PDF (4.86 MB)

View on publisher's site

View statistics

Full metadata record

Field	Value	Language
dc.contributor.author	Wang, T
dc.contributor.author	Gu, W
dc.contributor.author	Yu, L
dc.contributor.author	Guo, X https://orcid.org/0000-0001-7771-0463
dc.contributor.author	Yang, J
dc.contributor.author	Sun, X
dc.contributor.author	Guan, J
dc.contributor.author	Zhou, L
dc.contributor.author	Wang, C
dc.contributor.author	Yao, H
dc.contributor.author	Zhang, X
dc.contributor.author	Wang, G https://orcid.org/0000-0003-4295-8578
dc.date.accessioned	2024-02-14T03:22:39Z
dc.date.available	2024-02-14T03:22:39Z
dc.date.issued	2023-11-01
dc.identifier.citation	Journal of Materiomics, 2023, 9, (6), pp. 1129-1140
dc.identifier.issn	2352-8478
dc.identifier.issn	2352-8486
dc.identifier.uri	http://hdl.handle.net/10453/175673
dc.description.abstract	MXene, a family of two-dimensional (2D) transition metal carbides and nitrides have attracted extensive interests for many biochemical applications, including tumour elimination, biosensors, and magnetic resonance imaging (MRI). In this article, we firstly discovered that Ti3C2Tx MXene exhibited a highly efficient adsorption capability as hemoperfusion absorbent towards middle-molecular mass and protein bound uremic toxins in the end stage of renal disease (ESRD) treatment. Molecular scale investigations reveal that the high efficiency of MXene for the removal of uremic toxins could be attributed to synergistic effects of physical/chemical adsorption, electrostatic interaction surface of 2D MXene, and transformation of protein secondary structure. 2D MXene materials could be used as a new hemoperfusion sorbent with ultrahigh efficiency for removing uremic toxins during the treatment of kidney disease.
dc.language	English
dc.publisher	ELSEVIER
dc.relation	http://purl.org/au-research/grants/arc/DP170100436
dc.relation.ispartof	Journal of Materiomics
dc.relation.isbasedon	10.1016/j.jmat.2023.06.010
dc.rights	info:eu-repo/semantics/openAccess
dc.subject.classification	4016 Materials engineering
dc.subject.classification	4018 Nanotechnology
dc.title	MXene: An efficient hemoperfusion sorbent for the removal of uremic toxins
dc.type	Journal Article
utslib.citation.volume	9
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Science
pubs.organisational-group	University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	University of Technology Sydney/Strength - CCET - Centre for Clean Energy Technology
utslib.copyright.status	open_access	*
dc.date.updated	2024-02-14T03:22:36Z
pubs.issue	6
pubs.publication-status	Published
pubs.volume	9
utslib.citation.issue	6

Abstract:

MXene, a family of two-dimensional (2D) transition metal carbides and nitrides have attracted extensive interests for many biochemical applications, including tumour elimination, biosensors, and magnetic resonance imaging (MRI). In this article, we firstly discovered that Ti3C2Tx MXene exhibited a highly efficient adsorption capability as hemoperfusion absorbent towards middle-molecular mass and protein bound uremic toxins in the end stage of renal disease (ESRD) treatment. Molecular scale investigations reveal that the high efficiency of MXene for the removal of uremic toxins could be attributed to synergistic effects of physical/chemical adsorption, electrostatic interaction surface of 2D MXene, and transformation of protein secondary structure. 2D MXene materials could be used as a new hemoperfusion sorbent with ultrahigh efficiency for removing uremic toxins during the treatment of kidney disease.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/175673