Curcumin nanoparticles combined with 3D printed bionic tumor models for breast cancer treatment.

Su, Y; Hu, X; Kang, Y; Zhang, C; Cheng, YY; Jiao, Z; Nie, Y; Song, K

Curcumin nanoparticles combined with 3D printed bionic tumor models for breast cancer treatment.

Su, Y Hu, X Kang, Y Zhang, C Cheng, YY Jiao, Z Nie, Y Song, K

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Publisher:: IOP Publishing
Publication Type:: Journal Article
Citation:: Biofabrication, 2023, 15, (1), pp. 014105
Issue Date:: 2023

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Field	Value	Language
dc.contributor.author	Su, Y
dc.contributor.author	Hu, X
dc.contributor.author	Kang, Y
dc.contributor.author	Zhang, C
dc.contributor.author	Cheng, YY
dc.contributor.author	Jiao, Z
dc.contributor.author	Nie, Y
dc.contributor.author	Song, K
dc.date.accessioned	2024-02-20T23:45:42Z
dc.date.available	2022-11-24
dc.date.available	2024-02-20T23:45:42Z
dc.date.issued	2023
dc.identifier.citation	Biofabrication, 2023, 15, (1), pp. 014105
dc.identifier.issn	1758-5082
dc.identifier.issn	1758-5090
dc.identifier.uri	http://hdl.handle.net/10453/175780
dc.description.abstract	Compared with conventional therapeutic approaches, nanomedicines are attracting a growing interest due to their better targeting ability, higher delivery efficiency, and good water solubility. However, conventional drug efficacy assessment methods are based on a two-dimensional (2D) culture approach of single cells to obtainin vitrotherapeutic effects, which may not be representative of actual tumors. Based on the above considerations, the three-dimensional (3D) cell culture models became a better choice since they can increase the complexity ofin vitrosystems and provide a biomimetic microenvironment that is closer to thein vivonative than 2D cultures. In our study, curcumin nanoparticle (CurNPs) with good water solubility and good tumor therapeutic effects were prepared by combining polymeric non-ionic surfactant (Pluronic F127) with curcumin. The hybrid scaffolds based on nano-clay, sodium alginate, and gelatin were also prepared, which showed good printability and excellent biocompatibility. We then studied the therapeutic effects of CurNPs on metastatic breast cancer using a 3D tumor model fabricated with scaffold-bound metastatic breast cancer (MDA-MB-231) cells. It was showed that the 3D cell model presented better cell proliferation effect while compared with 2D version. Additionally, there was good enhanced permeability and retention effect when CurNPs entered with better accumulate in 3D cell 'tumor' sites which represented more realistic response of a more real tumor treatment effect for breast cancer cells. Our study indicated that the combinational of nanomaterials with 3D cell 'tumor' models provided an alternative and better platform for drug screening and has great potential be used as safe and effective treatment screening for breast cancer.
dc.format	Electronic
dc.language	eng
dc.publisher	IOP Publishing
dc.relation.ispartof	Biofabrication
dc.relation.isbasedon	10.1088/1758-5090/aca5b8
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	0903 Biomedical Engineering, 1004 Medical Biotechnology, 1099 Other Technology
dc.subject.classification	3206 Medical biotechnology
dc.subject.classification	4003 Biomedical engineering
dc.subject.mesh	Bionics
dc.subject.mesh	Breast Neoplasms
dc.subject.mesh	Curcumin
dc.subject.mesh	Female
dc.subject.mesh	Humans
dc.subject.mesh	Nanoparticles
dc.subject.mesh	Printing, Three-Dimensional
dc.subject.mesh	Tumor Microenvironment
dc.subject.mesh	Water
dc.subject.mesh	Humans
dc.subject.mesh	Female
dc.subject.mesh	Breast Neoplasms
dc.subject.mesh	Curcumin
dc.subject.mesh	Bionics
dc.subject.mesh	Nanoparticles
dc.subject.mesh	Printing, Three-Dimensional
dc.subject.mesh	Water
dc.subject.mesh	Tumor Microenvironment
dc.subject.mesh	Humans
dc.subject.mesh	Breast Neoplasms
dc.subject.mesh	Water
dc.subject.mesh	Curcumin
dc.subject.mesh	Bionics
dc.subject.mesh	Female
dc.subject.mesh	Nanoparticles
dc.subject.mesh	Tumor Microenvironment
dc.subject.mesh	Printing, Three-Dimensional
dc.subject.mesh	Humans
dc.subject.mesh	Female
dc.subject.mesh	Breast Neoplasms
dc.subject.mesh	Curcumin
dc.subject.mesh	Bionics
dc.subject.mesh	Nanoparticles
dc.subject.mesh	Printing, Three-Dimensional
dc.subject.mesh	Water
dc.subject.mesh	Tumor Microenvironment
dc.title	Curcumin nanoparticles combined with 3D printed bionic tumor models for breast cancer treatment.
dc.type	Journal Article
utslib.citation.volume	15
utslib.location.activity	England
utslib.for	0903 Biomedical Engineering
utslib.for	1004 Medical Biotechnology
utslib.for	1099 Other Technology
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Science
pubs.organisational-group	University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	University of Technology Sydney/Strength - IBMD - Initiative for Biomedical Devices
utslib.copyright.status	closed_access	*
pubs.consider-herdc	false
dc.date.updated	2024-02-20T23:45:39Z
pubs.issue	1
pubs.publication-status	Published online
pubs.volume	15
utslib.citation.issue	1

Abstract:

Compared with conventional therapeutic approaches, nanomedicines are attracting a growing interest due to their better targeting ability, higher delivery efficiency, and good water solubility. However, conventional drug efficacy assessment methods are based on a two-dimensional (2D) culture approach of single cells to obtainin vitrotherapeutic effects, which may not be representative of actual tumors. Based on the above considerations, the three-dimensional (3D) cell culture models became a better choice since they can increase the complexity ofin vitrosystems and provide a biomimetic microenvironment that is closer to thein vivonative than 2D cultures. In our study, curcumin nanoparticle (CurNPs) with good water solubility and good tumor therapeutic effects were prepared by combining polymeric non-ionic surfactant (Pluronic F127) with curcumin. The hybrid scaffolds based on nano-clay, sodium alginate, and gelatin were also prepared, which showed good printability and excellent biocompatibility. We then studied the therapeutic effects of CurNPs on metastatic breast cancer using a 3D tumor model fabricated with scaffold-bound metastatic breast cancer (MDA-MB-231) cells. It was showed that the 3D cell model presented better cell proliferation effect while compared with 2D version. Additionally, there was good enhanced permeability and retention effect when CurNPs entered with better accumulate in 3D cell 'tumor' sites which represented more realistic response of a more real tumor treatment effect for breast cancer cells. Our study indicated that the combinational of nanomaterials with 3D cell 'tumor' models provided an alternative and better platform for drug screening and has great potential be used as safe and effective treatment screening for breast cancer.

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http://hdl.handle.net/10453/175780