Fabrication and detection of a novel hybrid conductive scaffold based on alginate/gelatin/carboxylated carbon nanotubes (Alg/Gel/mMWCNTs) for neural tissue engineering.
- Publisher:
- Elsevier
- Publication Type:
- Journal Article
- Citation:
- Tissue Cell, 2023, 80, pp. 101995
- Issue Date:
- 2023-02
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1-s2.0-S0040816622002671-main.pdf | Published version | 14.96 MB | Adobe PDF |
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Full metadata record
Field | Value | Language |
---|---|---|
dc.contributor.author | Ma, H | |
dc.contributor.author | Yu, K | |
dc.contributor.author | Wang, H | |
dc.contributor.author | Liu, J | |
dc.contributor.author | Cheng, YY | |
dc.contributor.author | Kang, Y | |
dc.contributor.author | Wang, H | |
dc.contributor.author | Zhang, J | |
dc.contributor.author | Song, K | |
dc.date.accessioned | 2024-02-21T00:25:52Z | |
dc.date.available | 2022-12-03 | |
dc.date.available | 2024-02-21T00:25:52Z | |
dc.date.issued | 2023-02 | |
dc.identifier.citation | Tissue Cell, 2023, 80, pp. 101995 | |
dc.identifier.issn | 0040-8166 | |
dc.identifier.issn | 1532-3072 | |
dc.identifier.uri | http://hdl.handle.net/10453/175781 | |
dc.description.abstract | Carbon nanotubes (CNTs), as kinds of conductive carbon nanomaterials, were widely applied in neural tissue engineering due to their excellent electrical conductivity and good biocompatibility. In this study, the carboxyl-modified multi-walled carbon nanotubes (mMWCNTs) were introduced into sodium alginate/gelatin (Alg/Gel) scaffolds to optimize the function of the hybrid scaffolds. The Alg/Gel/mMWCNTs conductive scaffolds with mMWCNTs content of 1%, 3%, and 5% were prepared by freeze-drying, respectively. Following this, the physicochemical properties and biocompatibility of the hybrid scaffolds at different magnetic field intensities were evaluated. The conductive scaffolds were characterized by Scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR). In general, the mMWCNTs addition improved the hydrophilic, electrical conductivity and mechanical properties of the composite scaffold, and PC12 cells showed a trend of gradual increase over culture time. Particularly, the Alg/Gel-1%C scaffold exhibited the best cell proliferation behavior. Briefly, the surface contact angle decreased from 74 ± 1° to 60 ± 3°, the electrical conductivity and compressive modulus increased to 1.32 × 10-3 ± 2.1 × 10-4 S/cm and 1.40 ± 0.076 Mpa, the G1 phase from 55.67 ± 1.86% to 59.77 ± 0.94% and the G2 phase from 10.32 ± 0.35% to 13.93 ± 1.26%,respectively. In the SEM images, PC12 cells were well-shaped and densely distributed. Therefore, the Alg/Gel/mMWCNTs conductive scaffold has potential as a tissue engineering scaffold in nerve regeneration. | |
dc.format | Print-Electronic | |
dc.language | eng | |
dc.publisher | Elsevier | |
dc.relation.ispartof | Tissue Cell | |
dc.relation.isbasedon | 10.1016/j.tice.2022.101995 | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject | 0601 Biochemistry and Cell Biology, 1116 Medical Physiology | |
dc.subject.classification | Biochemistry & Molecular Biology | |
dc.subject.classification | 3101 Biochemistry and cell biology | |
dc.subject.mesh | Rats | |
dc.subject.mesh | Animals | |
dc.subject.mesh | Tissue Engineering | |
dc.subject.mesh | Nanotubes, Carbon | |
dc.subject.mesh | Gelatin | |
dc.subject.mesh | Alginates | |
dc.subject.mesh | Tissue Scaffolds | |
dc.subject.mesh | Electric Conductivity | |
dc.subject.mesh | Animals | |
dc.subject.mesh | Rats | |
dc.subject.mesh | Nanotubes, Carbon | |
dc.subject.mesh | Alginates | |
dc.subject.mesh | Gelatin | |
dc.subject.mesh | Tissue Engineering | |
dc.subject.mesh | Electric Conductivity | |
dc.subject.mesh | Tissue Scaffolds | |
dc.subject.mesh | Rats | |
dc.subject.mesh | Animals | |
dc.subject.mesh | Tissue Engineering | |
dc.subject.mesh | Nanotubes, Carbon | |
dc.subject.mesh | Gelatin | |
dc.subject.mesh | Alginates | |
dc.subject.mesh | Tissue Scaffolds | |
dc.subject.mesh | Electric Conductivity | |
dc.title | Fabrication and detection of a novel hybrid conductive scaffold based on alginate/gelatin/carboxylated carbon nanotubes (Alg/Gel/mMWCNTs) for neural tissue engineering. | |
dc.type | Journal Article | |
utslib.citation.volume | 80 | |
utslib.location.activity | Scotland | |
utslib.for | 0601 Biochemistry and Cell Biology | |
utslib.for | 1116 Medical Physiology | |
pubs.organisational-group | University of Technology Sydney | |
pubs.organisational-group | University of Technology Sydney/Faculty of Science | |
pubs.organisational-group | University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences | |
pubs.organisational-group | University of Technology Sydney/Strength - IBMD - Initiative for Biomedical Devices | |
utslib.copyright.status | closed_access | * |
dc.date.updated | 2024-02-21T00:25:47Z | |
pubs.publication-status | Published | |
pubs.volume | 80 |
Abstract:
Carbon nanotubes (CNTs), as kinds of conductive carbon nanomaterials, were widely applied in neural tissue engineering due to their excellent electrical conductivity and good biocompatibility. In this study, the carboxyl-modified multi-walled carbon nanotubes (mMWCNTs) were introduced into sodium alginate/gelatin (Alg/Gel) scaffolds to optimize the function of the hybrid scaffolds. The Alg/Gel/mMWCNTs conductive scaffolds with mMWCNTs content of 1%, 3%, and 5% were prepared by freeze-drying, respectively. Following this, the physicochemical properties and biocompatibility of the hybrid scaffolds at different magnetic field intensities were evaluated. The conductive scaffolds were characterized by Scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR). In general, the mMWCNTs addition improved the hydrophilic, electrical conductivity and mechanical properties of the composite scaffold, and PC12 cells showed a trend of gradual increase over culture time. Particularly, the Alg/Gel-1%C scaffold exhibited the best cell proliferation behavior. Briefly, the surface contact angle decreased from 74 ± 1° to 60 ± 3°, the electrical conductivity and compressive modulus increased to 1.32 × 10-3 ± 2.1 × 10-4 S/cm and 1.40 ± 0.076 Mpa, the G1 phase from 55.67 ± 1.86% to 59.77 ± 0.94% and the G2 phase from 10.32 ± 0.35% to 13.93 ± 1.26%,respectively. In the SEM images, PC12 cells were well-shaped and densely distributed. Therefore, the Alg/Gel/mMWCNTs conductive scaffold has potential as a tissue engineering scaffold in nerve regeneration.
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