Role of wound microbiome, strategies of microbiota delivery system and clinical management.
Tang, Q
Xue, N
Ding, X
Tsai, KH-Y
Hew, JJ
Jiang, R
Huang, R
Cheng, X
Ding, X
Yee Cheng, Y
Chen, J
Wang, Y
- Publisher:
- Elsevier
- Publication Type:
- Journal Article
- Citation:
- Adv Drug Deliv Rev, 2023, 192, pp. 114671
- Issue Date:
- 2023-01
Closed Access
Filename | Description | Size | |||
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1-s2.0-S0169409X22005610-main.pdf | Published version | 1.81 MB | Adobe PDF |
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Full metadata record
Field | Value | Language |
---|---|---|
dc.contributor.author | Tang, Q | |
dc.contributor.author | Xue, N | |
dc.contributor.author | Ding, X | |
dc.contributor.author | Tsai, KH-Y | |
dc.contributor.author | Hew, JJ | |
dc.contributor.author | Jiang, R | |
dc.contributor.author | Huang, R | |
dc.contributor.author | Cheng, X | |
dc.contributor.author | Ding, X | |
dc.contributor.author | Yee Cheng, Y | |
dc.contributor.author | Chen, J | |
dc.contributor.author | Wang, Y | |
dc.date.accessioned | 2024-02-21T00:47:52Z | |
dc.date.available | 2022-12-14 | |
dc.date.available | 2024-02-21T00:47:52Z | |
dc.date.issued | 2023-01 | |
dc.identifier.citation | Adv Drug Deliv Rev, 2023, 192, pp. 114671 | |
dc.identifier.issn | 0169-409X | |
dc.identifier.issn | 1872-8294 | |
dc.identifier.uri | http://hdl.handle.net/10453/175783 | |
dc.description.abstract | Delayed wound healing is one of the most global public health threats affecting nearly 100 million people each year, particularly the chronic wounds. Many confounding factors such as aging, diabetic disease, medication, peripheral neuropathy, immunocompromises or arterial and venous insufficiency hyperglycaemia are considered to inhibit wound healing. Therapeutic approaches for slow wound healing include anti-infection, debridement and the use of various wound dressings. However, the current clinical outcomes are still unsatisfied. In this review, we discuss the role of skin and wound commensal microbiota in the different healing stages, including inflammation, cell proliferation, re-epithelialization and remodelling phase, followed by multiple immune cell responses to commensal microbiota. Current clinical management in treating surgical wounds and chronic wounds was also reviewed together with potential controlled delivery systems which may be utilized in the future for the topical administration of probiotics and microbiomes. This review aims to introduce advances, novel strategies, and pioneer ideas in regulating the wound microbiome and the design of controlled delivery systems. | |
dc.format | Print-Electronic | |
dc.language | eng | |
dc.publisher | Elsevier | |
dc.relation.ispartof | Adv Drug Deliv Rev | |
dc.relation.isbasedon | 10.1016/j.addr.2022.114671 | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject | 1115 Pharmacology and Pharmaceutical Sciences | |
dc.subject.classification | Pharmacology & Pharmacy | |
dc.subject.classification | 3214 Pharmacology and pharmaceutical sciences | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Wound Healing | |
dc.subject.mesh | Skin | |
dc.subject.mesh | Anti-Infective Agents | |
dc.subject.mesh | Microbiota | |
dc.subject.mesh | Administration, Topical | |
dc.subject.mesh | Skin | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Anti-Infective Agents | |
dc.subject.mesh | Administration, Topical | |
dc.subject.mesh | Wound Healing | |
dc.subject.mesh | Microbiota | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Wound Healing | |
dc.subject.mesh | Skin | |
dc.subject.mesh | Anti-Infective Agents | |
dc.subject.mesh | Microbiota | |
dc.subject.mesh | Administration, Topical | |
dc.title | Role of wound microbiome, strategies of microbiota delivery system and clinical management. | |
dc.type | Journal Article | |
utslib.citation.volume | 192 | |
utslib.location.activity | Netherlands | |
utslib.for | 1115 Pharmacology and Pharmaceutical Sciences | |
pubs.organisational-group | University of Technology Sydney | |
pubs.organisational-group | University of Technology Sydney/Faculty of Science | |
pubs.organisational-group | University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences | |
pubs.organisational-group | University of Technology Sydney/Strength - IBMD - Initiative for Biomedical Devices | |
utslib.copyright.status | closed_access | * |
dc.date.updated | 2024-02-21T00:47:51Z | |
pubs.publication-status | Published | |
pubs.volume | 192 |
Abstract:
Delayed wound healing is one of the most global public health threats affecting nearly 100 million people each year, particularly the chronic wounds. Many confounding factors such as aging, diabetic disease, medication, peripheral neuropathy, immunocompromises or arterial and venous insufficiency hyperglycaemia are considered to inhibit wound healing. Therapeutic approaches for slow wound healing include anti-infection, debridement and the use of various wound dressings. However, the current clinical outcomes are still unsatisfied. In this review, we discuss the role of skin and wound commensal microbiota in the different healing stages, including inflammation, cell proliferation, re-epithelialization and remodelling phase, followed by multiple immune cell responses to commensal microbiota. Current clinical management in treating surgical wounds and chronic wounds was also reviewed together with potential controlled delivery systems which may be utilized in the future for the topical administration of probiotics and microbiomes. This review aims to introduce advances, novel strategies, and pioneer ideas in regulating the wound microbiome and the design of controlled delivery systems.
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