Effects of temperature and pH on the synthesis of nanohydroxyapatite powders by chemical precipitation

Mahmutoglu, G; Topsakal, A; Altan, E; Kuskonmaz, N; Daglilar, S; Oktar, FN; Erdemir, G; Kuruca, SE; Akyol, S; Gunduz, O; Ben-Nissan, B

Effects of temperature and pH on the synthesis of nanohydroxyapatite powders by chemical precipitation

Mahmutoglu, G Topsakal, A Altan, E Kuskonmaz, N Daglilar, S Oktar, FN Erdemir, G Kuruca, SE Akyol, S Gunduz, O Ben-Nissan, B

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Publisher:: Springer Nature
Publication Type:: Journal Article
Citation:: Journal of the Australian Ceramic Society, 2023, 59, (5), pp. 1433-1441
Issue Date:: 2023-12-01

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Field	Value	Language
dc.contributor.author	Mahmutoglu, G
dc.contributor.author	Topsakal, A
dc.contributor.author	Altan, E
dc.contributor.author	Kuskonmaz, N
dc.contributor.author	Daglilar, S
dc.contributor.author	Oktar, FN
dc.contributor.author	Erdemir, G
dc.contributor.author	Kuruca, SE
dc.contributor.author	Akyol, S
dc.contributor.author	Gunduz, O
dc.contributor.author	Ben-Nissan, B
dc.date.accessioned	2024-03-09T20:13:24Z
dc.date.available	2024-03-09T20:13:24Z
dc.date.issued	2023-12-01
dc.identifier.citation	Journal of the Australian Ceramic Society, 2023, 59, (5), pp. 1433-1441
dc.identifier.issn	2510-1560
dc.identifier.issn	2510-1579
dc.identifier.uri	http://hdl.handle.net/10453/176406
dc.description.abstract	Bone tissue engineering is based on a comprehensive understanding of bone structure, bone mechanics, and biology. In order to create nanostructured hydroxyapatite powders with customized properties, many synthesis strategies such as wet chemical precipitation, sol-gel, hydrothermal, and biomimetic approaches have been intensively researched through the years. Calcium phosphate (CaP)-based ceramic nanoparticles, including hydroxyapatite (HAp), were synthesized by the chemical precipitation technique at pH ranges of 7 to 11 and different calcination temperatures of 600 to 1100 °C. The synthesized powders were characterized by several techniques, including scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), X-ray powder diffraction (XRD), energy dispersive X-ray analysis (EDX), and in vitro cell culture assays. The particle size analysis and zeta potential of these powders were also carried out using the dynamic light scattering (DLS) and laser Doppler electrophoresis methods. The results showed that the pH levels of 9 to 11 range and calcination temperatures of 600 to 800 °C were adequate for appropriate nanohydroxyapatite powder production using this method. The particle size of the nanohydroxyapatite was approximately 55 nm, although they were agglomerated after calcination. The biocompatibility tests demonstrated that these nanohydroxyapatite (nHAp) powders produced have appropriate cytocompatibility and can be used for bone graft production and other biomedical applications.
dc.language	en
dc.publisher	Springer Nature
dc.relation.ispartof	Journal of the Australian Ceramic Society
dc.relation.isbasedon	10.1007/s41779-023-00927-2
dc.rights	info:eu-repo/semantics/closedAccess
dc.title	Effects of temperature and pH on the synthesis of nanohydroxyapatite powders by chemical precipitation
dc.type	Journal Article
utslib.citation.volume	59
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Science
pubs.organisational-group	University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	closed_access	*
dc.date.updated	2024-03-09T20:13:22Z
pubs.issue	5
pubs.publication-status	Published
pubs.volume	59
utslib.citation.issue	5

Abstract:

Bone tissue engineering is based on a comprehensive understanding of bone structure, bone mechanics, and biology. In order to create nanostructured hydroxyapatite powders with customized properties, many synthesis strategies such as wet chemical precipitation, sol-gel, hydrothermal, and biomimetic approaches have been intensively researched through the years. Calcium phosphate (CaP)-based ceramic nanoparticles, including hydroxyapatite (HAp), were synthesized by the chemical precipitation technique at pH ranges of 7 to 11 and different calcination temperatures of 600 to 1100 °C. The synthesized powders were characterized by several techniques, including scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), X-ray powder diffraction (XRD), energy dispersive X-ray analysis (EDX), and in vitro cell culture assays. The particle size analysis and zeta potential of these powders were also carried out using the dynamic light scattering (DLS) and laser Doppler electrophoresis methods. The results showed that the pH levels of 9 to 11 range and calcination temperatures of 600 to 800 °C were adequate for appropriate nanohydroxyapatite powder production using this method. The particle size of the nanohydroxyapatite was approximately 55 nm, although they were agglomerated after calcination. The biocompatibility tests demonstrated that these nanohydroxyapatite (nHAp) powders produced have appropriate cytocompatibility and can be used for bone graft production and other biomedical applications.

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http://hdl.handle.net/10453/176406