Dual-Site Förster Resonance Energy Transfer Route of Upconversion Nanoparticles-Based Brain-Targeted Nanotheranostic Boosts the Near-Infrared Phototherapy of Glioma.

Wang, J; Shangguan, P; Lin, M; Fu, L; Liu, Y; Han, L; Chen, S; Wang, X; Lu, M; Luo, Z; Zhong, Y; Shi, B; Bai, F

Dual-Site Förster Resonance Energy Transfer Route of Upconversion Nanoparticles-Based Brain-Targeted Nanotheranostic Boosts the Near-Infrared Phototherapy of Glioma.

Wang, J Shangguan, P Lin, M Fu, L

Liu, Y Han, L Chen, S Wang, X Lu, M Luo, Z Zhong, Y Shi, B Bai, F

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Publisher:: AMER CHEMICAL SOC
Publication Type:: Journal Article
Citation:: ACS Nano, 2023, 17, (17), pp. 16840-16853
Issue Date:: 2023-09-12

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Field	Value	Language
dc.contributor.author	Wang, J
dc.contributor.author	Shangguan, P
dc.contributor.author	Lin, M
dc.contributor.author	Fu, L https://orcid.org/0000-0001-8871-358X
dc.contributor.author	Liu, Y
dc.contributor.author	Han, L
dc.contributor.author	Chen, S
dc.contributor.author	Wang, X
dc.contributor.author	Lu, M
dc.contributor.author	Luo, Z
dc.contributor.author	Zhong, Y
dc.contributor.author	Shi, B
dc.contributor.author	Bai, F
dc.date.accessioned	2024-03-11T02:48:39Z
dc.date.available	2024-03-11T02:48:39Z
dc.date.issued	2023-09-12
dc.identifier.citation	ACS Nano, 2023, 17, (17), pp. 16840-16853
dc.identifier.issn	1936-0851
dc.identifier.issn	1936-086X
dc.identifier.uri	http://hdl.handle.net/10453/176450
dc.description.abstract	Glioblastoma multiforme (GBM) is the most common malignant brain tumor with low survival, primarily due to the blood-brain barrier (BBB) and high infiltration. Upconversion nanoparticles (UCNPs)-based near-infrared (NIR) phototherapy with deep penetration is a promising therapy method against glioma but faces low photoenergy utilization that is induced by spectral mismatch and single-site Förster resonance energy transfer (FRET). Herein, we designed a brain-targeting NIR theranostic system with a dual-site FRET route and superior spectral matching to maximize energy utilization for synergistic photodynamic and photothermal therapy of glioma. The system was fabricated by Tm-doped UCNPs, zinc tetraphenylporphyrin (ZnTPP), and copper sulfide (CuS) nanoparticles under multioptimized modulation. First, the Tm-doping ratio was precisely adjusted to improve the relative emission intensity at 475 nm of UCNPs (11.5-fold). Moreover, the J-aggregate of ZnTPP increased the absorption at 475 nm (163.5-fold) of monomer; both together optimize the FRET matching between UCNPs and porphyrin for effective NIR photodynamic therapy. Simultaneously, the emission at 800 nm was utilized to magnify the photothermal effect of CuS nanoparticles for photothermal therapy via the second FRET route. After being modified by a brain-targeted peptide, the system efficiently triggers the synergistic phototherapy ablation of glioma cells and significantly prolongs the survival of orthotopic glioma-bearing mice after traversing the BBB and targeting glioma. This success of advanced spectral modulation and dual-site FRET strategy may inspire more strategies to maximize the photoenergy utilization of UCNPs for brain diseases.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	AMER CHEMICAL SOC
dc.relation.ispartof	ACS Nano
dc.relation.isbasedon	10.1021/acsnano.3c03724
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject.classification	Nanoscience & Nanotechnology
dc.subject.mesh	Animals
dc.subject.mesh	Mice
dc.subject.mesh	Fluorescence Resonance Energy Transfer
dc.subject.mesh	Theranostic Nanomedicine
dc.subject.mesh	Brain
dc.subject.mesh	Phototherapy
dc.subject.mesh	Glioma
dc.subject.mesh	Brain Neoplasms
dc.subject.mesh	Nanoparticles
dc.subject.mesh	Brain
dc.subject.mesh	Animals
dc.subject.mesh	Mice
dc.subject.mesh	Glioma
dc.subject.mesh	Brain Neoplasms
dc.subject.mesh	Phototherapy
dc.subject.mesh	Fluorescence Resonance Energy Transfer
dc.subject.mesh	Nanoparticles
dc.subject.mesh	Theranostic Nanomedicine
dc.subject.mesh	Animals
dc.subject.mesh	Mice
dc.subject.mesh	Fluorescence Resonance Energy Transfer
dc.subject.mesh	Theranostic Nanomedicine
dc.subject.mesh	Brain
dc.subject.mesh	Phototherapy
dc.subject.mesh	Glioma
dc.subject.mesh	Brain Neoplasms
dc.subject.mesh	Nanoparticles
dc.title	Dual-Site Förster Resonance Energy Transfer Route of Upconversion Nanoparticles-Based Brain-Targeted Nanotheranostic Boosts the Near-Infrared Phototherapy of Glioma.
dc.type	Journal Article
utslib.citation.volume	17
utslib.location.activity	United States
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Science
pubs.organisational-group	University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	University of Technology Sydney/Strength - IBMD - Initiative for Biomedical Devices
utslib.copyright.status	closed_access	*
dc.date.updated	2024-03-11T02:48:37Z
pubs.issue	17
pubs.publication-status	Published
pubs.volume	17
utslib.citation.issue	17

Abstract:

Glioblastoma multiforme (GBM) is the most common malignant brain tumor with low survival, primarily due to the blood-brain barrier (BBB) and high infiltration. Upconversion nanoparticles (UCNPs)-based near-infrared (NIR) phototherapy with deep penetration is a promising therapy method against glioma but faces low photoenergy utilization that is induced by spectral mismatch and single-site Förster resonance energy transfer (FRET). Herein, we designed a brain-targeting NIR theranostic system with a dual-site FRET route and superior spectral matching to maximize energy utilization for synergistic photodynamic and photothermal therapy of glioma. The system was fabricated by Tm-doped UCNPs, zinc tetraphenylporphyrin (ZnTPP), and copper sulfide (CuS) nanoparticles under multioptimized modulation. First, the Tm-doping ratio was precisely adjusted to improve the relative emission intensity at 475 nm of UCNPs (11.5-fold). Moreover, the J-aggregate of ZnTPP increased the absorption at 475 nm (163.5-fold) of monomer; both together optimize the FRET matching between UCNPs and porphyrin for effective NIR photodynamic therapy. Simultaneously, the emission at 800 nm was utilized to magnify the photothermal effect of CuS nanoparticles for photothermal therapy via the second FRET route. After being modified by a brain-targeted peptide, the system efficiently triggers the synergistic phototherapy ablation of glioma cells and significantly prolongs the survival of orthotopic glioma-bearing mice after traversing the BBB and targeting glioma. This success of advanced spectral modulation and dual-site FRET strategy may inspire more strategies to maximize the photoenergy utilization of UCNPs for brain diseases.

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http://hdl.handle.net/10453/176450