Mechanochemical synthesis and characterization of strontium substituted apatite for biomedical application

Otsuka, Y; Ben-Nissan, B; Kono, H; Sasaki, T; Kikuchi, M

Mechanochemical synthesis and characterization of strontium substituted apatite for biomedical application

Otsuka, Y Ben-Nissan, B Kono, H Sasaki, T Kikuchi, M

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Publisher:: Elsevier
Publication Type:: Journal Article
Citation:: Open Ceramics, 2023, 16, pp. 100459
Issue Date:: 2023-12-01

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Field	Value	Language
dc.contributor.author	Otsuka, Y
dc.contributor.author	Ben-Nissan, B
dc.contributor.author	Kono, H
dc.contributor.author	Sasaki, T
dc.contributor.author	Kikuchi, M
dc.date.accessioned	2024-03-13T04:33:49Z
dc.date.available	2024-03-13T04:33:49Z
dc.date.issued	2023-12-01
dc.identifier.citation	Open Ceramics, 2023, 16, pp. 100459
dc.identifier.issn	2666-5395
dc.identifier.issn	2666-5395
dc.identifier.uri	http://hdl.handle.net/10453/176634
dc.description.abstract	Strontium-substituted apatite has been proposed as a promising material for osteoporosis treatment. Several synthesis methods have been attempted in the past. In this study, we investigated a method known as the mechanochemical synthesis method. Characterization was carried out using different amounts of strontium ions in the hydroxyapatite (HAp) matrix with FT-IR spectral analysis, X-ray diffraction, lattice constant measurements, differential thermal analysis (DTA), terahertz spectroscopy, and investigation of the basic morphology using scanning electron microscopy (SEM), energy dispersive X-ray analysis (EDX). We report that the development and performance of mechanochemical synthetic pathways are more efficient and economical than other substituted apatite formation methods and are useful in the biomedical field to produce calcium phosphate-based clinical materials. The FTIR spectra, terahertz spectra, and XRD analysis results revealed that the mixture of dicalcium phosphate dihydrate (DCPD), Ca(OH)2 and Sr(OH)2 8H2O was phase-transformed into strontium-containing carbonate amorphous apatite by this simple and economical mechanochemical synthesis method.
dc.language	en
dc.publisher	Elsevier
dc.relation.ispartof	Open Ceramics
dc.relation.isbasedon	10.1016/j.oceram.2023.100459
dc.rights	info:eu-repo/semantics/openAccess
dc.title	Mechanochemical synthesis and characterization of strontium substituted apatite for biomedical application
dc.type	Journal Article
utslib.citation.volume	16
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Science
pubs.organisational-group	University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	open_access	*
dc.date.updated	2024-03-13T04:33:45Z
pubs.publication-status	Published
pubs.volume	16

Abstract:

Strontium-substituted apatite has been proposed as a promising material for osteoporosis treatment. Several synthesis methods have been attempted in the past. In this study, we investigated a method known as the mechanochemical synthesis method. Characterization was carried out using different amounts of strontium ions in the hydroxyapatite (HAp) matrix with FT-IR spectral analysis, X-ray diffraction, lattice constant measurements, differential thermal analysis (DTA), terahertz spectroscopy, and investigation of the basic morphology using scanning electron microscopy (SEM), energy dispersive X-ray analysis (EDX). We report that the development and performance of mechanochemical synthetic pathways are more efficient and economical than other substituted apatite formation methods and are useful in the biomedical field to produce calcium phosphate-based clinical materials. The FTIR spectra, terahertz spectra, and XRD analysis results revealed that the mixture of dicalcium phosphate dihydrate (DCPD), Ca(OH)2 and Sr(OH)2 8H2O was phase-transformed into strontium-containing carbonate amorphous apatite by this simple and economical mechanochemical synthesis method.

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http://hdl.handle.net/10453/176634