Recent Advances in Anticancer Activity of Novel Plant Extracts and Compounds from Curcuma longa in Hepatocellular Carcinoma.

Gull, N; Arshad, F; Naikoo, GA; Hassan, IU; Pedram, MZ; Ahmad, A; Aljabali, AAA; Mishra, V; Satija, S; Charbe, N; Negi, P; Goyal, R; Serrano-Aroca, Á; Al Zoubi, MS; El-Tanani, M; Tambuwala, MM

Recent Advances in Anticancer Activity of Novel Plant Extracts and Compounds from Curcuma longa in Hepatocellular Carcinoma.

Gull, N Arshad, F Naikoo, GA Hassan, IU Pedram, MZ Ahmad, A Aljabali, AAA Mishra, V Satija, S

Charbe, N Negi, P Goyal, R Serrano-Aroca, Á Al Zoubi, MS El-Tanani, M Tambuwala, MM

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Publisher:: SPRINGER
Publication Type:: Journal Article
Citation:: J Gastrointest Cancer, 2023, 54, (2), pp. 1-23
Issue Date:: 2023

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Field	Value	Language
dc.contributor.author	Gull, N
dc.contributor.author	Arshad, F
dc.contributor.author	Naikoo, GA
dc.contributor.author	Hassan, IU
dc.contributor.author	Pedram, MZ
dc.contributor.author	Ahmad, A
dc.contributor.author	Aljabali, AAA
dc.contributor.author	Mishra, V
dc.contributor.author	Satija, S https://orcid.org/0000-0003-4702-6534
dc.contributor.author	Charbe, N
dc.contributor.author	Negi, P
dc.contributor.author	Goyal, R
dc.contributor.author	Serrano-Aroca, Á
dc.contributor.author	Al Zoubi, MS
dc.contributor.author	El-Tanani, M
dc.contributor.author	Tambuwala, MM
dc.date.accessioned	2024-03-26T01:07:26Z
dc.date.available	2022-01-20
dc.date.available	2024-03-26T01:07:26Z
dc.date.issued	2023
dc.identifier.citation	J Gastrointest Cancer, 2023, 54, (2), pp. 1-23
dc.identifier.issn	1941-6628
dc.identifier.issn	1941-6636
dc.identifier.uri	http://hdl.handle.net/10453/177152
dc.description.abstract	PURPOSE: Among all forms of cancers, hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide. There are several treatment options for HCC ranging from loco-regional therapy to surgical treatment. Yet, there is high morbidity and mortality. Recent research focus has shifted towards more effective and less toxic cancer treatment options. Curcumin, the active ingredient in the Curcuma longa plant, has gained widespread attention in recent years because of its multifunctional properties as an antioxidant, anti-inflammatory, antimicrobial, and anticancer agent. METHODS: A systematic search of PubMed, Embase and Google Scholar was performed for studies reporting incidence of HCC, risk factors associated with cirrhosis and experimental use of curcumin as an anti-cancer agent. RESULTS: This review exclusively encompasses the anti-cancer properties of curcumin in HCC globally and it's postulated molecular targets of curcumin when used against liver cancers. CONCLUSIONS: This review is concluded by presenting the current challenges and future perspectives of novel plant extracts derived from C. longa and the treatment options against cancers.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	SPRINGER
dc.relation.ispartof	J Gastrointest Cancer
dc.relation.isbasedon	10.1007/s12029-022-00809-z
dc.rights	info:eu-repo/semantics/openAccess
dc.subject.classification	Gastroenterology & Hepatology
dc.subject.classification	3202 Clinical sciences
dc.subject.classification	3211 Oncology and carcinogenesis
dc.subject.mesh	Humans
dc.subject.mesh	Carcinoma, Hepatocellular
dc.subject.mesh	Curcumin
dc.subject.mesh	Liver Neoplasms
dc.subject.mesh	Curcuma
dc.subject.mesh	Plant Extracts
dc.subject.mesh	Humans
dc.subject.mesh	Curcuma
dc.subject.mesh	Carcinoma, Hepatocellular
dc.subject.mesh	Liver Neoplasms
dc.subject.mesh	Curcumin
dc.subject.mesh	Plant Extracts
dc.subject.mesh	Humans
dc.subject.mesh	Carcinoma, Hepatocellular
dc.subject.mesh	Curcumin
dc.subject.mesh	Liver Neoplasms
dc.subject.mesh	Curcuma
dc.subject.mesh	Plant Extracts
dc.title	Recent Advances in Anticancer Activity of Novel Plant Extracts and Compounds from Curcuma longa in Hepatocellular Carcinoma.
dc.type	Journal Article
utslib.citation.volume	54
utslib.location.activity	United States
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Science
utslib.copyright.status	open_access	*
pubs.consider-herdc	false
dc.date.updated	2024-03-26T01:07:24Z
pubs.issue	2
pubs.publication-status	Published online
pubs.volume	54
utslib.citation.issue	2

Abstract:

PURPOSE: Among all forms of cancers, hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide. There are several treatment options for HCC ranging from loco-regional therapy to surgical treatment. Yet, there is high morbidity and mortality. Recent research focus has shifted towards more effective and less toxic cancer treatment options. Curcumin, the active ingredient in the Curcuma longa plant, has gained widespread attention in recent years because of its multifunctional properties as an antioxidant, anti-inflammatory, antimicrobial, and anticancer agent. METHODS: A systematic search of PubMed, Embase and Google Scholar was performed for studies reporting incidence of HCC, risk factors associated with cirrhosis and experimental use of curcumin as an anti-cancer agent. RESULTS: This review exclusively encompasses the anti-cancer properties of curcumin in HCC globally and it's postulated molecular targets of curcumin when used against liver cancers. CONCLUSIONS: This review is concluded by presenting the current challenges and future perspectives of novel plant extracts derived from C. longa and the treatment options against cancers.

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http://hdl.handle.net/10453/177152