Nutrition and Developmental Origins of Kidney Disease.

Nguyen, LT; Pollock, CA; Saad, S

Nutrition and Developmental Origins of Kidney Disease.

Nguyen, LT Pollock, CA Saad, S

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Publisher:: MDPI
Publication Type:: Journal Article
Citation:: Nutrients, 2023, 15, (19), pp. 4207
Issue Date:: 2023-09-29

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Field	Value	Language
dc.contributor.author	Nguyen, LT
dc.contributor.author	Pollock, CA
dc.contributor.author	Saad, S
dc.date.accessioned	2024-03-28T01:31:04Z
dc.date.available	2023-09-28
dc.date.available	2024-03-28T01:31:04Z
dc.date.issued	2023-09-29
dc.identifier.citation	Nutrients, 2023, 15, (19), pp. 4207
dc.identifier.issn	2072-6643
dc.identifier.issn	2072-6643
dc.identifier.uri	http://hdl.handle.net/10453/177314
dc.description.abstract	The developmental programming hypothesis proposes that adverse environmental insults during critical developmental periods increase the risk of diseases later in life. The kidneys are deemed susceptible to such a process, although the exact mechanisms remain elusive. Many factors have been reported to contribute to the developmental origin of chronic kidney diseases (CKD), among which peri-gestational nutrition has a central role, affecting kidney development and metabolism. Physiologically, the link between malnutrition, reduced glomerular numbers, and increased blood pressure is key in the developmental programming of CKD. However, recent studies regarding oxidative stress, mitochondrial dysfunction, epigenetic modifications, and metabolic changes have revealed potential novel pathways for therapeutic intervention. This review will discuss the role of imbalanced nutrition in the development of CKD.
dc.format	Electronic
dc.language	eng
dc.publisher	MDPI
dc.relation.ispartof	Nutrients
dc.relation.isbasedon	10.3390/nu15194207
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	0908 Food Sciences, 1111 Nutrition and Dietetics
dc.subject.classification	3202 Clinical sciences
dc.subject.classification	3210 Nutrition and dietetics
dc.subject.classification	4206 Public health
dc.subject.mesh	Pregnancy
dc.subject.mesh	Female
dc.subject.mesh	Humans
dc.subject.mesh	Prenatal Nutritional Physiological Phenomena
dc.subject.mesh	Nutritional Status
dc.subject.mesh	Malnutrition
dc.subject.mesh	Epigenesis, Genetic
dc.subject.mesh	Renal Insufficiency, Chronic
dc.subject.mesh	Humans
dc.subject.mesh	Malnutrition
dc.subject.mesh	Epigenesis, Genetic
dc.subject.mesh	Nutritional Status
dc.subject.mesh	Pregnancy
dc.subject.mesh	Female
dc.subject.mesh	Renal Insufficiency, Chronic
dc.subject.mesh	Prenatal Nutritional Physiological Phenomena
dc.subject.mesh	Pregnancy
dc.subject.mesh	Female
dc.subject.mesh	Humans
dc.subject.mesh	Prenatal Nutritional Physiological Phenomena
dc.subject.mesh	Nutritional Status
dc.subject.mesh	Malnutrition
dc.subject.mesh	Epigenesis, Genetic
dc.subject.mesh	Renal Insufficiency, Chronic
dc.title	Nutrition and Developmental Origins of Kidney Disease.
dc.type	Journal Article
utslib.citation.volume	15
utslib.location.activity	Switzerland
utslib.for	0908 Food Sciences
utslib.for	1111 Nutrition and Dietetics
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Science
pubs.organisational-group	University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	open_access	*
dc.date.updated	2024-03-28T01:31:02Z
pubs.issue	19
pubs.publication-status	Published online
pubs.volume	15
utslib.citation.issue	19

Abstract:

The developmental programming hypothesis proposes that adverse environmental insults during critical developmental periods increase the risk of diseases later in life. The kidneys are deemed susceptible to such a process, although the exact mechanisms remain elusive. Many factors have been reported to contribute to the developmental origin of chronic kidney diseases (CKD), among which peri-gestational nutrition has a central role, affecting kidney development and metabolism. Physiologically, the link between malnutrition, reduced glomerular numbers, and increased blood pressure is key in the developmental programming of CKD. However, recent studies regarding oxidative stress, mitochondrial dysfunction, epigenetic modifications, and metabolic changes have revealed potential novel pathways for therapeutic intervention. This review will discuss the role of imbalanced nutrition in the development of CKD.

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http://hdl.handle.net/10453/177314