Sex steroid hormones and DNA repair regulation: Implications on cancer treatment responses.

Rangsrikitphoti, P; Marquez-Garban, DC; Pietras, RJ; McGowan, E; Boonyaratanakornkit, V

Sex steroid hormones and DNA repair regulation: Implications on cancer treatment responses.

Rangsrikitphoti, P Marquez-Garban, DC Pietras, RJ McGowan, E

Boonyaratanakornkit, V

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Publisher:: Elsevier
Publication Type:: Journal Article
Citation:: J Steroid Biochem Mol Biol, 2023, 227, pp. 106230
Issue Date:: 2023-03

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Field	Value	Language
dc.contributor.author	Rangsrikitphoti, P
dc.contributor.author	Marquez-Garban, DC
dc.contributor.author	Pietras, RJ
dc.contributor.author	McGowan, E https://orcid.org/0000-0001-6371-3751
dc.contributor.author	Boonyaratanakornkit, V
dc.date.accessioned	2024-04-02T00:24:55Z
dc.date.available	2022-11-25
dc.date.available	2024-04-02T00:24:55Z
dc.date.issued	2023-03
dc.identifier.citation	J Steroid Biochem Mol Biol, 2023, 227, pp. 106230
dc.identifier.issn	0960-0760
dc.identifier.issn	1879-1220
dc.identifier.uri	http://hdl.handle.net/10453/177400
dc.description.abstract	The role of sex steroid hormones (SSHs) has been shown to modulate cancer cytotoxic treatment sensitivity. Dysregulation of DNA repair associated with genomic instability, abnormal cell survival and not only promotes cancer progression but also resistance to cancer treatment. The three major SSHs, androgen, estrogen, and progesterone, have been shown to interact with several essential DNA repair components. The presence of androgens directly regulates key molecules in DNA double-strand break (DSB) repair. Estrogen can promote cell proliferation and DNA repair, allowing cancer cells to tolerate chemotherapy and radiotherapy. Information on the role of progesterone in DNA repair is limited: progesterone interaction with some DNA repair components has been identified, but the biological significance is still unknown. Here, we review the roles of how each SSH affects DNA repair regulation and modulates response to genotoxic therapies and discuss future research that can be beneficial when combining SSHs with cancer therapy. We also provide preliminary analysis from publicly available databases defining the link between progesterone/PR and DDRs & DNA repair regulation that plausibly contribute to chemotherapy response and breast cancer patient survival.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Elsevier
dc.relation.ispartof	J Steroid Biochem Mol Biol
dc.relation.isbasedon	10.1016/j.jsbmb.2022.106230
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	0301 Analytical Chemistry, 0601 Biochemistry and Cell Biology
dc.subject.classification	Endocrinology & Metabolism
dc.subject.classification	3101 Biochemistry and cell biology
dc.subject.classification	3401 Analytical chemistry
dc.subject.mesh	Humans
dc.subject.mesh	Female
dc.subject.mesh	Progesterone
dc.subject.mesh	DNA Repair
dc.subject.mesh	DNA Breaks, Double-Stranded
dc.subject.mesh	Breast Neoplasms
dc.subject.mesh	Estrogens
dc.subject.mesh	Androgens
dc.subject.mesh	Humans
dc.subject.mesh	Breast Neoplasms
dc.subject.mesh	Progesterone
dc.subject.mesh	Androgens
dc.subject.mesh	Estrogens
dc.subject.mesh	DNA Repair
dc.subject.mesh	Female
dc.subject.mesh	DNA Breaks, Double-Stranded
dc.subject.mesh	Humans
dc.subject.mesh	Female
dc.subject.mesh	Progesterone
dc.subject.mesh	DNA Repair
dc.subject.mesh	DNA Breaks, Double-Stranded
dc.subject.mesh	Breast Neoplasms
dc.subject.mesh	Estrogens
dc.subject.mesh	Androgens
dc.title	Sex steroid hormones and DNA repair regulation: Implications on cancer treatment responses.
dc.type	Journal Article
utslib.citation.volume	227
utslib.location.activity	England
utslib.for	0301 Analytical Chemistry
utslib.for	0601 Biochemistry and Cell Biology
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Science
utslib.copyright.status	closed_access	*
dc.date.updated	2024-04-02T00:24:54Z
pubs.publication-status	Published
pubs.volume	227

Abstract:

The role of sex steroid hormones (SSHs) has been shown to modulate cancer cytotoxic treatment sensitivity. Dysregulation of DNA repair associated with genomic instability, abnormal cell survival and not only promotes cancer progression but also resistance to cancer treatment. The three major SSHs, androgen, estrogen, and progesterone, have been shown to interact with several essential DNA repair components. The presence of androgens directly regulates key molecules in DNA double-strand break (DSB) repair. Estrogen can promote cell proliferation and DNA repair, allowing cancer cells to tolerate chemotherapy and radiotherapy. Information on the role of progesterone in DNA repair is limited: progesterone interaction with some DNA repair components has been identified, but the biological significance is still unknown. Here, we review the roles of how each SSH affects DNA repair regulation and modulates response to genotoxic therapies and discuss future research that can be beneficial when combining SSHs with cancer therapy. We also provide preliminary analysis from publicly available databases defining the link between progesterone/PR and DDRs & DNA repair regulation that plausibly contribute to chemotherapy response and breast cancer patient survival.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/177400