Effect of citalopram and sertraline on the expression of miRNA- 124, 132, and 16 and their protein targets in patients with depression
- Publication Type:
- Journal Article
- Citation:
- Iranian Journal of Basic Medical Sciences, 2023, 26, (7), pp. 820-829
- Issue Date:
- 2023-01-01
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Objectives This study aimed to evaluate the effect of SSRIs on the expression of miRNAs and their protein targets Materials and Methods In a 100 day open label study of citalopram n 25 and sertraline n 25 levels of miRNA 16 132 and 124 and glucocorticoid receptor GR Brain derived neurotrophic factor BDNF and serotonin transporter SERT protein expression were measured by QRT PCR and western blot in healthy control n 20 patients with depression at the baseline and same patients after 100 days of treatment Results Expression levels of GR and BDNF proteins were lower in the depressed group before treatment as compared with the healthy group i P lt i 0 0001 The SERT level was higher among the depressed group before treatment in comparison with the healthy group i P lt i 0 0001 The level of GR and BDNF significantly increased and SERT expression decreased after receiving sertraline i P lt i 0 05 When the depressed group received citalopram only SERT and GR were altered i P lt i 0 05 Among the microRNAs expression investigated mir 124 and mir 132 were higher and mir 16 was lower among the depressed compared with the healthy group i P lt i 0 0001 Individuals receiving citalopram only showed an increase in the expression of mir 16 while administration of sertraline led to a significant increase in the expression of mir 16 and a decrease in mir 124 and mir 132 i P lt i 0 05 Conclusion This elucidated the relationship between antidepressant treatment and the expression of different microRNA that control gene expression in various pathways involved in depressed patients Receiving SSRI can affect the level of these proteins and their relevant microRNAs
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