Spatial analysis of the metastatic brain tumor immune and extracellular matrix microenvironment

Widodo, SS; Dinevska, M; Cuzcano, L; Papanicolaou, M; Cox, TR; Stylli, SS; Mantamadiotis, T

Spatial analysis of the metastatic brain tumor immune and extracellular matrix microenvironment

Widodo, SS Dinevska, M Cuzcano, L Papanicolaou, M

Cox, TR Stylli, SS Mantamadiotis, T

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Publisher:: Elsevier
Publication Type:: Journal Article
Citation:: Advances in Cancer Biology - Metastasis, 2023, 7, pp. 100096
Issue Date:: 2023-07

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Field	Value	Language
dc.contributor.author	Widodo, SS
dc.contributor.author	Dinevska, M
dc.contributor.author	Cuzcano, L
dc.contributor.author	Papanicolaou, M https://orcid.org/0000-0002-7998-3171
dc.contributor.author	Cox, TR
dc.contributor.author	Stylli, SS
dc.contributor.author	Mantamadiotis, T
dc.date.accessioned	2024-05-27T22:35:13Z
dc.date.available	2024-05-27T22:35:13Z
dc.date.issued	2023-07
dc.identifier.citation	Advances in Cancer Biology - Metastasis, 2023, 7, pp. 100096
dc.identifier.issn	2667-3940
dc.identifier.uri	http://hdl.handle.net/10453/179258
dc.description.abstract	Metastatic cancer is responsible for the overwhelming majority of cancer related deaths with metastatic tumors being the most common neoplasms affecting the central nervous system One of the major factors regulating tumor biology is the tumor microenvironment However little is known about the cellular and non cellular composition of metastatic brain tumors and how tumor cell ontogeny influences the metastatic brain tumor microenvironment By integrating multiplex immunohistochemistry and histopathological analysis to investigate composition and the spatial relationship between neoplastic cells infiltrating and brain resident immune cells and the extracellular matrix we demonstrate that metastatic brain tumors exhibit differences in extracellular matrix deposition compared with the most common primary brain tumor type glioblastoma and that the dominant immune cell types in metastatic brain tumors are immunosuppressive macrophages which preferentially localize to extracellular matrix rich stromal regions
dc.language	en
dc.publisher	Elsevier
dc.relation.ispartof	Advances in Cancer Biology - Metastasis
dc.relation.isbasedon	10.1016/j.adcanc.2023.100096
dc.rights	info:eu-repo/semantics/openAccess
dc.title	Spatial analysis of the metastatic brain tumor immune and extracellular matrix microenvironment
dc.type	Journal Article
utslib.citation.volume	7
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Science
pubs.organisational-group	University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	open_access	*
pubs.consider-herdc	true
dc.date.updated	2024-05-27T22:35:11Z
pubs.publication-status	Published
pubs.volume	7

Abstract:

Metastatic cancer is responsible for the overwhelming majority of cancer related deaths with metastatic tumors being the most common neoplasms affecting the central nervous system One of the major factors regulating tumor biology is the tumor microenvironment However little is known about the cellular and non cellular composition of metastatic brain tumors and how tumor cell ontogeny influences the metastatic brain tumor microenvironment By integrating multiplex immunohistochemistry and histopathological analysis to investigate composition and the spatial relationship between neoplastic cells infiltrating and brain resident immune cells and the extracellular matrix we demonstrate that metastatic brain tumors exhibit differences in extracellular matrix deposition compared with the most common primary brain tumor type glioblastoma and that the dominant immune cell types in metastatic brain tumors are immunosuppressive macrophages which preferentially localize to extracellular matrix rich stromal regions

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http://hdl.handle.net/10453/179258