New insight into marine alkaloid metabolic pathways: Revisiting oroidin biosynthesis

John Wiley & Sons
Publication Type:
Journal Article
ChemBiochem, 2011, 12 (15), pp. 2298 - 2301
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A highly sensitive in vivo protocol based on 14C radiolabeled precursors and beta-imager autoradiography allowed the unraveling of the origin of the pyrrole 2-aminoimidazole-containing key biosynthetic intermediate oroidin. Proline and lysine are now proposed as the early precursors of the pyrrole and the 2-aminoimidazole moieties of oroidin respectively.
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