In situ characterization of the tumor microenvironment.

Sadeghirad, H; Yaghoubi Naei, V; O'Byrne, K; Warkiani, ME; Kulasinghe, A

In situ characterization of the tumor microenvironment.

Sadeghirad, H Yaghoubi Naei, V O'Byrne, K Warkiani, ME Kulasinghe, A

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Publisher:: ELSEVIER SCI LTD
Publication Type:: Journal Article
Citation:: Curr Opin Biotechnol, 2024, 86, pp. 103083
Issue Date:: 2024-04

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Field	Value	Language
dc.contributor.author	Sadeghirad, H
dc.contributor.author	Yaghoubi Naei, V
dc.contributor.author	O'Byrne, K
dc.contributor.author	Warkiani, ME
dc.contributor.author	Kulasinghe, A
dc.date.accessioned	2024-08-14T01:55:11Z
dc.date.available	2024-01-30
dc.date.available	2024-08-14T01:55:11Z
dc.date.issued	2024-04
dc.identifier.citation	Curr Opin Biotechnol, 2024, 86, pp. 103083
dc.identifier.issn	0958-1669
dc.identifier.issn	1879-0429
dc.identifier.uri	http://hdl.handle.net/10453/180404
dc.description.abstract	The development of new therapies for cancer is underpinned by an increasing need to comprehensively characterize the tumor microenvironment (TME). While traditional approaches have relied on bulk or single-cell approaches, these are limited in their ability to provide cellular context. Deconvolution of the complex TME is fundamental to understanding tumor dynamics and treatment resistance. Spatially resolved characterization of the TME is likely to provide greater insights into the cellular architecture, tumor-immune cell interactions, receptor-ligand interactions, and cell niches. In turn, these aid in dictating the optimal way in which to target each patient's individual cancer. In this review, we discuss a number of cutting-edge in situ spatial profiling methods giving us new insights into tumor biology.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	ELSEVIER SCI LTD
dc.relation.ispartof	Curr Opin Biotechnol
dc.relation.isbasedon	10.1016/j.copbio.2024.103083
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	06 Biological Sciences, 09 Engineering, 10 Technology
dc.subject.classification	Biotechnology
dc.subject.classification	3001 Agricultural biotechnology
dc.subject.classification	3106 Industrial biotechnology
dc.subject.classification	3206 Medical biotechnology
dc.subject.mesh	Humans
dc.subject.mesh	Tumor Microenvironment
dc.subject.mesh	Cell Communication
dc.subject.mesh	Neoplasms
dc.subject.mesh	Humans
dc.subject.mesh	Neoplasms
dc.subject.mesh	Cell Communication
dc.subject.mesh	Tumor Microenvironment
dc.subject.mesh	Humans
dc.subject.mesh	Tumor Microenvironment
dc.subject.mesh	Cell Communication
dc.subject.mesh	Neoplasms
dc.title	In situ characterization of the tumor microenvironment.
dc.type	Journal Article
utslib.citation.volume	86
utslib.location.activity	England
utslib.for	06 Biological Sciences
utslib.for	09 Engineering
utslib.for	10 Technology
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	University of Technology Sydney/Strength - CHT - Health Technologies
pubs.organisational-group	University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	University of Technology Sydney/All Manual Groups
pubs.organisational-group	University of Technology Sydney/All Manual Groups/Centre for Health Technologies (CHT)
utslib.copyright.status	open_access	*
dc.rights.license	This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0). To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/
dc.date.updated	2024-08-14T01:55:09Z
pubs.publication-status	Published
pubs.volume	86

Abstract:

The development of new therapies for cancer is underpinned by an increasing need to comprehensively characterize the tumor microenvironment (TME). While traditional approaches have relied on bulk or single-cell approaches, these are limited in their ability to provide cellular context. Deconvolution of the complex TME is fundamental to understanding tumor dynamics and treatment resistance. Spatially resolved characterization of the TME is likely to provide greater insights into the cellular architecture, tumor-immune cell interactions, receptor-ligand interactions, and cell niches. In turn, these aid in dictating the optimal way in which to target each patient's individual cancer. In this review, we discuss a number of cutting-edge in situ spatial profiling methods giving us new insights into tumor biology.

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http://hdl.handle.net/10453/180404