Detection of Streptococcus pyogenes M1UK in Australia and characterization of the mutation driving enhanced expression of superantigen SpeA.
Davies, MR
Keller, N
Brouwer, S
Jespersen, MG
Cork, AJ
Hayes, AJ
Pitt, ME
De Oliveira, DMP
Harbison-Price, N
Bertolla, OM
Mediati, DG
Curren, BF
Taiaroa, G
Lacey, JA
Smith, HV
Fang, N-X
Coin, LJM
Stevens, K
Tong, SYC
Sanderson-Smith, M
Tree, JJ
Irwin, AD
Grimwood, K
Howden, BP
Jennison, AV
Walker, MJ
- Publisher:
- NATURE PORTFOLIO
- Publication Type:
- Journal Article
- Citation:
- Nat Commun, 2023, 14, (1), pp. 1051
- Issue Date:
- 2023-02-24
Open Access
Copyright Clearance Process
- Recently Added
- In Progress
- Open Access
This item is open access.
Full metadata record
Field | Value | Language |
---|---|---|
dc.contributor.author | Davies, MR | |
dc.contributor.author | Keller, N | |
dc.contributor.author | Brouwer, S | |
dc.contributor.author | Jespersen, MG | |
dc.contributor.author | Cork, AJ | |
dc.contributor.author | Hayes, AJ | |
dc.contributor.author | Pitt, ME | |
dc.contributor.author | De Oliveira, DMP | |
dc.contributor.author | Harbison-Price, N | |
dc.contributor.author | Bertolla, OM | |
dc.contributor.author | Mediati, DG | |
dc.contributor.author | Curren, BF | |
dc.contributor.author | Taiaroa, G | |
dc.contributor.author | Lacey, JA | |
dc.contributor.author | Smith, HV | |
dc.contributor.author | Fang, N-X | |
dc.contributor.author | Coin, LJM | |
dc.contributor.author | Stevens, K | |
dc.contributor.author | Tong, SYC | |
dc.contributor.author | Sanderson-Smith, M | |
dc.contributor.author | Tree, JJ | |
dc.contributor.author | Irwin, AD | |
dc.contributor.author | Grimwood, K | |
dc.contributor.author | Howden, BP | |
dc.contributor.author | Jennison, AV | |
dc.contributor.author | Walker, MJ | |
dc.date.accessioned | 2024-09-13T05:48:41Z | |
dc.date.available | 2023-02-13 | |
dc.date.available | 2024-09-13T05:48:41Z | |
dc.date.issued | 2023-02-24 | |
dc.identifier.citation | Nat Commun, 2023, 14, (1), pp. 1051 | |
dc.identifier.issn | 2041-1723 | |
dc.identifier.issn | 2041-1723 | |
dc.identifier.uri | http://hdl.handle.net/10453/180815 | |
dc.description.abstract | A new variant of Streptococcus pyogenes serotype M1 (designated 'M1UK') has been reported in the United Kingdom, linked with seasonal scarlet fever surges, marked increase in invasive infections, and exhibiting enhanced expression of the superantigen SpeA. The progenitor S. pyogenes 'M1global' and M1UK clones can be differentiated by 27 SNPs and 4 indels, yet the mechanism for speA upregulation is unknown. Here we investigate the previously unappreciated expansion of M1UK in Australia, now isolated from the majority of serious infections caused by serotype M1 S. pyogenes. M1UK sub-lineages circulating in Australia also contain a novel toxin repertoire associated with epidemic scarlet fever causing S. pyogenes in Asia. A single SNP in the 5' transcriptional leader sequence of the transfer-messenger RNA gene ssrA drives enhanced SpeA superantigen expression as a result of ssrA terminator read-through in the M1UK lineage. This represents a previously unappreciated mechanism of toxin expression and urges enhanced international surveillance. | |
dc.format | Electronic | |
dc.language | eng | |
dc.publisher | NATURE PORTFOLIO | |
dc.relation.ispartof | Nat Commun | |
dc.relation.isbasedon | 10.1038/s41467-023-36717-4 | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Streptococcus pyogenes | |
dc.subject.mesh | Scarlet Fever | |
dc.subject.mesh | Superantigens | |
dc.subject.mesh | Bacterial Proteins | |
dc.subject.mesh | United Kingdom | |
dc.subject.mesh | Exotoxins | |
dc.subject.mesh | Mutation | |
dc.subject.mesh | Australia | |
dc.subject.mesh | Streptococcal Infections | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Streptococcus pyogenes | |
dc.subject.mesh | Streptococcal Infections | |
dc.subject.mesh | Scarlet Fever | |
dc.subject.mesh | Bacterial Proteins | |
dc.subject.mesh | Exotoxins | |
dc.subject.mesh | Superantigens | |
dc.subject.mesh | Mutation | |
dc.subject.mesh | Australia | |
dc.subject.mesh | United Kingdom | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Streptococcus pyogenes | |
dc.subject.mesh | Scarlet Fever | |
dc.subject.mesh | Superantigens | |
dc.subject.mesh | Bacterial Proteins | |
dc.subject.mesh | United Kingdom | |
dc.subject.mesh | Exotoxins | |
dc.subject.mesh | Mutation | |
dc.subject.mesh | Australia | |
dc.subject.mesh | Streptococcal Infections | |
dc.title | Detection of Streptococcus pyogenes M1UK in Australia and characterization of the mutation driving enhanced expression of superantigen SpeA. | |
dc.type | Journal Article | |
utslib.citation.volume | 14 | |
utslib.location.activity | England | |
pubs.organisational-group | University of Technology Sydney | |
pubs.organisational-group | University of Technology Sydney/Faculty of Science | |
utslib.copyright.status | open_access | * |
dc.rights.license | This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0). To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/ | |
dc.date.updated | 2024-09-13T05:48:37Z | |
pubs.issue | 1 | |
pubs.publication-status | Published online | |
pubs.volume | 14 | |
utslib.citation.issue | 1 |
Abstract:
A new variant of Streptococcus pyogenes serotype M1 (designated 'M1UK') has been reported in the United Kingdom, linked with seasonal scarlet fever surges, marked increase in invasive infections, and exhibiting enhanced expression of the superantigen SpeA. The progenitor S. pyogenes 'M1global' and M1UK clones can be differentiated by 27 SNPs and 4 indels, yet the mechanism for speA upregulation is unknown. Here we investigate the previously unappreciated expansion of M1UK in Australia, now isolated from the majority of serious infections caused by serotype M1 S. pyogenes. M1UK sub-lineages circulating in Australia also contain a novel toxin repertoire associated with epidemic scarlet fever causing S. pyogenes in Asia. A single SNP in the 5' transcriptional leader sequence of the transfer-messenger RNA gene ssrA drives enhanced SpeA superantigen expression as a result of ssrA terminator read-through in the M1UK lineage. This represents a previously unappreciated mechanism of toxin expression and urges enhanced international surveillance.
Please use this identifier to cite or link to this item:
Download statistics for the last 12 months
Not enough data to produce graph