Class 1 integron-associated spread of resistance regions in Pseudomonas aeruginosa: plasmid or chromosomal platforms?

Oxford University Press
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Journal Article
Journal of Antimicrobial Chemotherapy, 2012, 67 (7), pp. 1799 - 1800
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Multidrug-resistant Pseudomonas aeruginosa infections are a growing clinical problem. Of particular concern is the range of b-lactamase genes associated with this species. If the spread of resistance is to be controlled, it is critical that researchers have a good understanding of the mechanisms by which resistance genes are spread. In the Enterobacteriaceae, the role of plasmids in the lateral gene transfer (LGT) of resistance is extensive. However, many clinical isolates of Gram-negative bacteria also commonly carry additional syntenic blocks of DNA as part of the chromosome that are lineage specific within a species and are known as genomic islands.
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