Myxoma T2 protein as a model for poxvirus TNF receptor homologs

McFadden, GI; Schreiber, M; Sedger, LM

Myxoma T2 protein as a model for poxvirus TNF receptor homologs

McFadden, GI Schreiber, M Sedger, LM

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Publisher:: Elsevier Science
Publication Type:: Journal Article
Citation:: Journal of Neuroimmunology, 1997, 72 pp. 2 - 119
Issue Date:: 1997-01

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Field	Value	Language
dc.contributor.author	McFadden, GI	en_US
dc.contributor.author	Schreiber, M	en_US
dc.contributor.author	Sedger, LM https://orcid.org/0000-0003-1009-5683	en_US
dc.contributor.editor	NA	en_US
dc.date.issued	1997-01	en_US
dc.identifier.citation	Journal of Neuroimmunology, 1997, 72 pp. 2 - 119	en_US
dc.identifier.issn	0165-5728	en_US
dc.identifier.uri	http://hdl.handle.net/10453/18166
dc.description.abstract	Many poxviruses encode a plethora of immunomodulatory proteins, including homologs of cellular cytokine receptors. These receptor mimics, also referred to as viroceptors, are believed to function by binding and sequestering host cytokines thus preventing their signaling cascade prior to receptor engagement. The M-T2 protein of myxoma virus is a TNF receptor homolog that has two distinct activities: the secreted dimeric M-T2 protein binds and inhibits TNF alpha while the intracellular version permits myxoma virus replication in infected T-lymphocytes by blocking the cellular apoptosis response to the virus infection. Studies with M-T2 mutants reveal that distinct protein domains mediate these two anti-immune properties of this protein.	en_US
dc.publisher	Elsevier Science	en_US
dc.relation.ispartof	Journal of Neuroimmunology	en_US
dc.subject.classification	Neurology & Neurosurgery	en_US
dc.title	Myxoma T2 protein as a model for poxvirus TNF receptor homologs	en_US
dc.type	Journal Article
utslib.citation.volume	72	en_US
utslib.location.activity	Rhodes, Greece	en_US
utslib.for	060103 Cell Development, Proliferation and Death	en_US
utslib.for	060506 Virology	en_US
utslib.for	1107 Immunology	en_US
utslib.for	1109 Neurosciences	en_US
dc.location.activity	Rhodes, Greece	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	closed_access
pubs.consider-herdc	false	en_US
pubs.volume	72	en_US

Abstract:

Many poxviruses encode a plethora of immunomodulatory proteins, including homologs of cellular cytokine receptors. These receptor mimics, also referred to as viroceptors, are believed to function by binding and sequestering host cytokines thus preventing their signaling cascade prior to receptor engagement. The M-T2 protein of myxoma virus is a TNF receptor homolog that has two distinct activities: the secreted dimeric M-T2 protein binds and inhibits TNF alpha while the intracellular version permits myxoma virus replication in infected T-lymphocytes by blocking the cellular apoptosis response to the virus infection. Studies with M-T2 mutants reveal that distinct protein domains mediate these two anti-immune properties of this protein.

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http://hdl.handle.net/10453/18166