Protective role of acetylcholine and the cholinergic system in the injured heart.

Liu Chung Ming, C; Wang, X; Gentile, C

Protective role of acetylcholine and the cholinergic system in the injured heart.

Liu Chung Ming, C Wang, X Gentile, C

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Publisher:: CELL PRESS
Publication Type:: Journal Article
Citation:: iScience, 2024, 27, (9), pp. 110726
Issue Date:: 2024-09-20

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Field	Value	Language
dc.contributor.author	Liu Chung Ming, C
dc.contributor.author	Wang, X
dc.contributor.author	Gentile, C https://orcid.org/0000-0002-3689-4275
dc.date.accessioned	2024-12-02T00:45:31Z
dc.date.available	2024-12-02T00:45:31Z
dc.date.issued	2024-09-20
dc.identifier.citation	iScience, 2024, 27, (9), pp. 110726
dc.identifier.issn	2589-0042
dc.identifier.issn	2589-0042
dc.identifier.uri	http://hdl.handle.net/10453/182168
dc.description.abstract	This review explores the roles of the cholinergic system in the heart, comprising the neuronal and non-neuronal cholinergic systems. Both systems are essential for maintaining cardiac homeostasis by regulating the release of acetylcholine (ACh). A reduction in ACh release is associated with the early onset of cardiovascular diseases (CVDs), and increasing evidence supports the protective roles of ACh against CVD. We address the challenges and limitations of current strategies to elevate ACh levels, including vagus nerve stimulation and pharmacological interventions such as cholinesterase inhibitors. Additionally, we introduce alternative strategies to increase ACh in the heart, such as stem cell therapy, gene therapy, microRNAs, and nanoparticle drug delivery methods. These findings offer new insights into advanced treatments for regenerating the injured human heart.
dc.format	Electronic-eCollection
dc.language	eng
dc.publisher	CELL PRESS
dc.relation.ispartof	iScience
dc.relation.isbasedon	10.1016/j.isci.2024.110726
dc.rights	info:eu-repo/semantics/openAccess
dc.title	Protective role of acetylcholine and the cholinergic system in the injured heart.
dc.type	Journal Article
utslib.citation.volume	27
utslib.location.activity	United States
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	University of Technology Sydney/UTS Groups
pubs.organisational-group	University of Technology Sydney/UTS Groups/Centre for Health Technologies (CHT)
utslib.copyright.status	open_access	*
dc.rights.license	This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0). To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/
dc.date.updated	2024-12-02T00:45:24Z
pubs.issue	9
pubs.publication-status	Published online
pubs.volume	27
utslib.citation.issue	9

Abstract:

This review explores the roles of the cholinergic system in the heart, comprising the neuronal and non-neuronal cholinergic systems. Both systems are essential for maintaining cardiac homeostasis by regulating the release of acetylcholine (ACh). A reduction in ACh release is associated with the early onset of cardiovascular diseases (CVDs), and increasing evidence supports the protective roles of ACh against CVD. We address the challenges and limitations of current strategies to elevate ACh levels, including vagus nerve stimulation and pharmacological interventions such as cholinesterase inhibitors. Additionally, we introduce alternative strategies to increase ACh in the heart, such as stem cell therapy, gene therapy, microRNAs, and nanoparticle drug delivery methods. These findings offer new insights into advanced treatments for regenerating the injured human heart.

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http://hdl.handle.net/10453/182168