Metabolic Effects of Access to Sucrose Drink in Female Rats and Transmission of Some Effects to Their Offspring.

Kendig, MD; Ekayanti, W; Stewart, H; Boakes, RA; Rooney, K

Metabolic Effects of Access to Sucrose Drink in Female Rats and Transmission of Some Effects to Their Offspring.

Kendig, MD Ekayanti, W Stewart, H Boakes, RA Rooney, K

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Publisher:: PUBLIC LIBRARY SCIENCE
Publication Type:: Journal Article
Citation:: PLoS One, 2015, 10, (7), pp. e0131107
Issue Date:: 2015

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Field	Value	Language
dc.contributor.author	Kendig, MD
dc.contributor.author	Ekayanti, W
dc.contributor.author	Stewart, H
dc.contributor.author	Boakes, RA
dc.contributor.author	Rooney, K
dc.contributor.editor	Glendinning, JI
dc.date.accessioned	2024-12-02T06:10:35Z
dc.date.available	2015-05-28
dc.date.available	2024-12-02T06:10:35Z
dc.date.issued	2015
dc.identifier.citation	PLoS One, 2015, 10, (7), pp. e0131107
dc.identifier.issn	1932-6203
dc.identifier.issn	1932-6203
dc.identifier.uri	http://hdl.handle.net/10453/182298
dc.description.abstract	The aims of this study were, first, to examine the metabolic consequences for female rats of having unrestricted access to 10% sucrose solution and, second, to test for effects of this dietary intervention on their offspring. In Stage 1 females were mated following a 4-week period in which one group was given the sucrose in addition to their normal chow and a control group was given chow and water only. Sucrose was removed at parturition and the pups monitored until weaning. Despite the development of glucose intolerance in sucrose-fed mothers, no effects were detected on litter size or pup weights. In Stage 2 voluntary activity of offspring was assessed over postnatal days (PND) 51-60 and their glucose tolerance measured at PND89-94. Again no effect of maternal diet was detected. Only male offspring were used in Stage 3, which began when they were 13 weeks old. Four groups were given 10% sucrose solution for 48 days in a 2 x 2 design, in which one factor was maternal diet and the other was whether they were given 2-h access to an activity wheel on alternate days. Higher fasting glucose levels were found in offspring of sugar-fed mothers. Exercise increased insulin sensitivity in these rats but not in offspring of control mothers. Behavioural measures of memory in Stage 3 did not reveal any effects of maternal diet or exercise. Overall, this study suggested that, while providing 10% sucrose solution ad-libitum was sufficient to impair maternal metabolism, the impact of this dietary manipulation on offspring may be revealed only when the offspring's diet is similarly manipulated.
dc.format	Electronic-eCollection
dc.language	eng
dc.publisher	PUBLIC LIBRARY SCIENCE
dc.relation.ispartof	PLoS One
dc.relation.isbasedon	10.1371/journal.pone.0131107
dc.rights	info:eu-repo/semantics/openAccess
dc.subject.classification	General Science & Technology
dc.subject.mesh	Animals
dc.subject.mesh	Animals, Newborn
dc.subject.mesh	Dietary Carbohydrates
dc.subject.mesh	Fasting
dc.subject.mesh	Female
dc.subject.mesh	Glucose Intolerance
dc.subject.mesh	Insulin Resistance
dc.subject.mesh	Male
dc.subject.mesh	Physical Conditioning, Animal
dc.subject.mesh	Pregnancy
dc.subject.mesh	Prenatal Exposure Delayed Effects
dc.subject.mesh	Rats
dc.subject.mesh	Sucrose
dc.subject.mesh	Weaning
dc.subject.mesh	Animals
dc.subject.mesh	Animals, Newborn
dc.subject.mesh	Rats
dc.subject.mesh	Prenatal Exposure Delayed Effects
dc.subject.mesh	Glucose Intolerance
dc.subject.mesh	Insulin Resistance
dc.subject.mesh	Dietary Carbohydrates
dc.subject.mesh	Sucrose
dc.subject.mesh	Fasting
dc.subject.mesh	Physical Conditioning, Animal
dc.subject.mesh	Weaning
dc.subject.mesh	Pregnancy
dc.subject.mesh	Female
dc.subject.mesh	Male
dc.subject.mesh	Animals
dc.subject.mesh	Animals, Newborn
dc.subject.mesh	Dietary Carbohydrates
dc.subject.mesh	Fasting
dc.subject.mesh	Female
dc.subject.mesh	Glucose Intolerance
dc.subject.mesh	Insulin Resistance
dc.subject.mesh	Male
dc.subject.mesh	Physical Conditioning, Animal
dc.subject.mesh	Pregnancy
dc.subject.mesh	Prenatal Exposure Delayed Effects
dc.subject.mesh	Rats
dc.subject.mesh	Sucrose
dc.subject.mesh	Weaning
dc.title	Metabolic Effects of Access to Sucrose Drink in Female Rats and Transmission of Some Effects to Their Offspring.
dc.type	Journal Article
utslib.citation.volume	10
utslib.location.activity	United States
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Science
pubs.organisational-group	University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	open_access	*
dc.rights.license	This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0). To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/
dc.date.updated	2024-12-02T06:10:28Z
pubs.issue	7
pubs.publication-status	Published online
pubs.volume	10
utslib.citation.issue	7

Abstract:

The aims of this study were, first, to examine the metabolic consequences for female rats of having unrestricted access to 10% sucrose solution and, second, to test for effects of this dietary intervention on their offspring. In Stage 1 females were mated following a 4-week period in which one group was given the sucrose in addition to their normal chow and a control group was given chow and water only. Sucrose was removed at parturition and the pups monitored until weaning. Despite the development of glucose intolerance in sucrose-fed mothers, no effects were detected on litter size or pup weights. In Stage 2 voluntary activity of offspring was assessed over postnatal days (PND) 51-60 and their glucose tolerance measured at PND89-94. Again no effect of maternal diet was detected. Only male offspring were used in Stage 3, which began when they were 13 weeks old. Four groups were given 10% sucrose solution for 48 days in a 2 x 2 design, in which one factor was maternal diet and the other was whether they were given 2-h access to an activity wheel on alternate days. Higher fasting glucose levels were found in offspring of sugar-fed mothers. Exercise increased insulin sensitivity in these rats but not in offspring of control mothers. Behavioural measures of memory in Stage 3 did not reveal any effects of maternal diet or exercise. Overall, this study suggested that, while providing 10% sucrose solution ad-libitum was sufficient to impair maternal metabolism, the impact of this dietary manipulation on offspring may be revealed only when the offspring's diet is similarly manipulated.

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http://hdl.handle.net/10453/182298