Furazan bis-ureas: a heterocyclic scaffold for anion binding and transport

Ryder, WG; Wu, EG; Chen, L; Fares, M; McNaughton, DA; Tran, K; Yu, C; Gale, PA

Furazan bis-ureas: a heterocyclic scaffold for anion binding and transport

Ryder, WG Wu, EG Chen, L Fares, M McNaughton, DA Tran, K Yu, C Gale, PA

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Publisher:: ROYAL SOC CHEMISTRY
Publication Type:: Journal Article
Citation:: Organic Chemistry Frontiers, 2024, 11, (5), pp. 1290-1298
Issue Date:: 2024-01-02

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Field	Value	Language
dc.contributor.author	Ryder, WG
dc.contributor.author	Wu, EG
dc.contributor.author	Chen, L
dc.contributor.author	Fares, M
dc.contributor.author	McNaughton, DA
dc.contributor.author	Tran, K
dc.contributor.author	Yu, C
dc.contributor.author	Gale, PA
dc.date.accessioned	2024-12-12T00:11:03Z
dc.date.available	2024-12-12T00:11:03Z
dc.date.issued	2024-01-02
dc.identifier.citation	Organic Chemistry Frontiers, 2024, 11, (5), pp. 1290-1298
dc.identifier.issn	2052-4110
dc.identifier.issn	2052-4129
dc.identifier.uri	http://hdl.handle.net/10453/182478
dc.description.abstract	The incorporation of hydrogen bonding motifs surrounding a central cyclic scaffold has proven to be an effective method in the design of synthetic anion transpoters. Herein, we report a novel and synthetically accessible architecture centred around an oxadiazole ring. The series was found to effectively mediate the perturbation of liposomal pH gradients at micromolar concentrations via a H+/Cl− transport mechanism and a wide range of cytotoxicities were exhibited against cancerous and normal cell lines.
dc.language	English
dc.publisher	ROYAL SOC CHEMISTRY
dc.relation	http://purl.org/au-research/grants/arc/DP200100453
dc.relation.ispartof	Organic Chemistry Frontiers
dc.relation.isbasedon	10.1039/d3qo01956j
dc.rights	info:eu-repo/semantics/embargoedAccess
dc.subject	0305 Organic Chemistry
dc.subject.classification	3405 Organic chemistry
dc.title	Furazan bis-ureas: a heterocyclic scaffold for anion binding and transport
dc.type	Journal Article
utslib.citation.volume	11
utslib.for	0305 Organic Chemistry
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Science
pubs.organisational-group	University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	University of Technology Sydney/UTS Groups
pubs.organisational-group	University of Technology Sydney/UTS Groups/The Kidman Centre (TKC)
utslib.copyright.status	open_access	*
utslib.copyright.embargo	2025-01-01T00:00:00+1000Z
dc.date.updated	2024-12-12T00:11:01Z
pubs.issue	5
pubs.publication-status	Published
pubs.volume	11
utslib.citation.issue	5

Abstract:

The incorporation of hydrogen bonding motifs surrounding a central cyclic scaffold has proven to be an effective method in the design of synthetic anion transpoters. Herein, we report a novel and synthetically accessible architecture centred around an oxadiazole ring. The series was found to effectively mediate the perturbation of liposomal pH gradients at micromolar concentrations via a H+/Cl− transport mechanism and a wide range of cytotoxicities were exhibited against cancerous and normal cell lines.

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http://hdl.handle.net/10453/182478