Generation of genetic and non-genetic risk factor-based mouse models resembling the sporadic human Alzheimer’s disease phenotype

Ganesan, Kiruthika

Generation of genetic and non-genetic risk factor-based mouse models resembling the sporadic human Alzheimer’s disease phenotype

Ganesan, Kiruthika

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Publication Type:: Thesis
Issue Date:: 2023

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Field	Value	Language
dc.contributor.author	Ganesan, Kiruthika
dc.date.accessioned	2025-01-20T23:50:39Z
dc.date.available	2025-01-20T23:50:39Z
dc.date.issued	2023
dc.identifier.uri	http://hdl.handle.net/10453/183890
dc.description	University of Technology Sydney. Faculty of Science.	en_US.UTF-8
dc.description.abstract	The overall aim of the current thesis was to create a better preclinical mouse model of sporadic Alzheimer’s disease (AD). Sporadic AD comprises over 95% of cases but the vast majority of preclinical AD models mimic the heritable, familial form of AD which comprise fewer than 5% of cases, which could be hampering translatability between species. The first half of this thesis employed experiments which examined several genetic and non-genetic risk factors, both individually and in combination, in an attempt to recapitulate the human sporadic AD phenotype. The second half of the thesis aimed to improve the translatability of this model from a behavioural perspective, by investigating the consequences of hippocampal neuroinflammation for a behaviour that is crucial to AD diagnosis but has been almost entirely overlooked in preclinical studies: goal-directed action control. The results of this thesis are suggestive of a number of important steps that future studies should take to better model Sporadic forms of Alzheimer’s. Additionally, these results provide valuable insights into the sex differences that result from targeted hippocampal neuroinflammation in mice, which is reflective of gender differences in human neurological conditions including Alzheimer’s and depressive disorders.	en_US.UTF-8
dc.format	Thesis (PhD)
dc.language.iso	en_US	en_US.UTF-8
dc.relation	https://opus.lib.uts.edu.au/bitstream/10453/183890/1/thesis.pdf
dc.rights	info:eu-repo/semantics/openAccess
dc.rights	The author owns the copyright in this thesis including all reproduction and reuse rights for the work. The work may not be altered without the permission of the copyright owner. Attribution is essential when quoting or paraphrasing from this thesis.
dc.rights	© 2023 Kiruthika Ganesan
dc.rights	au.edu.uts.lib/cph
dc.title	Generation of genetic and non-genetic risk factor-based mouse models resembling the sporadic human Alzheimer’s disease phenotype	en_US.UTF-8
dc.type	Thesis
utslib.copyright.status	open_access	*

Abstract:

The overall aim of the current thesis was to create a better preclinical mouse model of sporadic Alzheimer’s disease (AD). Sporadic AD comprises over 95% of cases but the vast majority of preclinical AD models mimic the heritable, familial form of AD which comprise fewer than 5% of cases, which could be hampering translatability between species. The first half of this thesis employed experiments which examined several genetic and non-genetic risk factors, both individually and in combination, in an attempt to recapitulate the human sporadic AD phenotype. The second half of the thesis aimed to improve the translatability of this model from a behavioural perspective, by investigating the consequences of hippocampal neuroinflammation for a behaviour that is crucial to AD diagnosis but has been almost entirely overlooked in preclinical studies: goal-directed action control. The results of this thesis are suggestive of a number of important steps that future studies should take to better model Sporadic forms of Alzheimer’s. Additionally, these results provide valuable insights into the sex differences that result from targeted hippocampal neuroinflammation in mice, which is reflective of gender differences in human neurological conditions including Alzheimer’s and depressive disorders.

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http://hdl.handle.net/10453/183890