Chronic restricted access to 10% sucrose solution in adolescent and young adult rats impairs spatial memory and alters sensitivity to outcome devaluation.

Kendig, MD; Boakes, RA; Rooney, KB; Corbit, LH

Chronic restricted access to 10% sucrose solution in adolescent and young adult rats impairs spatial memory and alters sensitivity to outcome devaluation.

Kendig, MD Boakes, RA Rooney, KB Corbit, LH

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Publisher:: PERGAMON-ELSEVIER SCIENCE LTD
Publication Type:: Journal Article
Citation:: Physiol Behav, 2013, 120, pp. 164-172
Issue Date:: 2013-08-15

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Field	Value	Language
dc.contributor.author	Kendig, MD
dc.contributor.author	Boakes, RA
dc.contributor.author	Rooney, KB
dc.contributor.author	Corbit, LH
dc.date.accessioned	2025-02-21T03:56:20Z
dc.date.available	2013-08-07
dc.date.available	2025-02-21T03:56:20Z
dc.date.issued	2013-08-15
dc.identifier.citation	Physiol Behav, 2013, 120, pp. 164-172
dc.identifier.issn	0031-9384
dc.identifier.issn	1873-507X
dc.identifier.uri	http://hdl.handle.net/10453/185245
dc.description.abstract	Although increasing consumption of sugar drinks is recognized as a significant public health concern, little is known about (a) the cognitive effects resulting from sucrose consumption; and (b) whether the long-term effects of sucrose consumption are more pronounced for adolescents. This experiment directly compared performance on a task of spatial learning and memory (the Morris Water Maze) and sensitivity to outcome devaluation following 28 days of 2-h/day access to a 10% sucrose solution in adolescent and young-adult Wistar rats. Sucrose groups developed elevated fasting blood glucose levels after the diet intervention, despite drawing <15% of calories from sucrose and gaining no more weight than controls. In subsequent behavioral testing, sucrose groups were impaired on the Morris Water Maze, with some residual deficits in spatial memory observed more than 6 weeks after the end of sucrose exposure. Further, results from outcome devaluation testing indicated that in the older cohort of rats, those fed sucrose showed reduced sensitivity to devaluation of the outcome, suggestive of differences in instrumental learning following sucrose exposure. Data provide strong evidence that sucrose consumption can induce deficits in spatial cognition and reward-oriented behavior at levels that resemble patterns of sugar drink consumption in young people, and which can remain long after exposure.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	PERGAMON-ELSEVIER SCIENCE LTD
dc.relation.ispartof	Physiol Behav
dc.relation.isbasedon	10.1016/j.physbeh.2013.08.012
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	06 Biological Sciences, 11 Medical and Health Sciences, 17 Psychology and Cognitive Sciences
dc.subject.classification	Behavioral Science & Comparative Psychology
dc.subject.classification	31 Biological sciences
dc.subject.classification	32 Biomedical and clinical sciences
dc.subject.classification	52 Psychology
dc.subject.mesh	Aging
dc.subject.mesh	Animals
dc.subject.mesh	Blood Glucose
dc.subject.mesh	Body Weight
dc.subject.mesh	Conditioning, Operant
dc.subject.mesh	Diet
dc.subject.mesh	Eating
dc.subject.mesh	Male
dc.subject.mesh	Maze Learning
dc.subject.mesh	Memory
dc.subject.mesh	Rats
dc.subject.mesh	Rats, Wistar
dc.subject.mesh	Reward
dc.subject.mesh	Solutions
dc.subject.mesh	Space Perception
dc.subject.mesh	Sucrose
dc.subject.mesh	Animals
dc.subject.mesh	Rats
dc.subject.mesh	Rats, Wistar
dc.subject.mesh	Body Weight
dc.subject.mesh	Blood Glucose
dc.subject.mesh	Sucrose
dc.subject.mesh	Solutions
dc.subject.mesh	Diet
dc.subject.mesh	Conditioning, Operant
dc.subject.mesh	Maze Learning
dc.subject.mesh	Memory
dc.subject.mesh	Reward
dc.subject.mesh	Space Perception
dc.subject.mesh	Aging
dc.subject.mesh	Eating
dc.subject.mesh	Male
dc.subject.mesh	Aging
dc.subject.mesh	Animals
dc.subject.mesh	Blood Glucose
dc.subject.mesh	Body Weight
dc.subject.mesh	Conditioning, Operant
dc.subject.mesh	Diet
dc.subject.mesh	Eating
dc.subject.mesh	Male
dc.subject.mesh	Maze Learning
dc.subject.mesh	Memory
dc.subject.mesh	Rats
dc.subject.mesh	Rats, Wistar
dc.subject.mesh	Reward
dc.subject.mesh	Solutions
dc.subject.mesh	Space Perception
dc.subject.mesh	Sucrose
dc.title	Chronic restricted access to 10% sucrose solution in adolescent and young adult rats impairs spatial memory and alters sensitivity to outcome devaluation.
dc.type	Journal Article
utslib.citation.volume	120
utslib.location.activity	United States
utslib.for	06 Biological Sciences
utslib.for	11 Medical and Health Sciences
utslib.for	17 Psychology and Cognitive Sciences
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Science
pubs.organisational-group	University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	University of Technology Sydney/UTS Groups
pubs.organisational-group	University of Technology Sydney/UTS Groups/Stroke Research Collaborative
utslib.copyright.status	closed_access	*
dc.date.updated	2025-02-21T03:56:18Z
pubs.publication-status	Published
pubs.volume	120

Abstract:

Although increasing consumption of sugar drinks is recognized as a significant public health concern, little is known about (a) the cognitive effects resulting from sucrose consumption; and (b) whether the long-term effects of sucrose consumption are more pronounced for adolescents. This experiment directly compared performance on a task of spatial learning and memory (the Morris Water Maze) and sensitivity to outcome devaluation following 28 days of 2-h/day access to a 10% sucrose solution in adolescent and young-adult Wistar rats. Sucrose groups developed elevated fasting blood glucose levels after the diet intervention, despite drawing <15% of calories from sucrose and gaining no more weight than controls. In subsequent behavioral testing, sucrose groups were impaired on the Morris Water Maze, with some residual deficits in spatial memory observed more than 6 weeks after the end of sucrose exposure. Further, results from outcome devaluation testing indicated that in the older cohort of rats, those fed sucrose showed reduced sensitivity to devaluation of the outcome, suggestive of differences in instrumental learning following sucrose exposure. Data provide strong evidence that sucrose consumption can induce deficits in spatial cognition and reward-oriented behavior at levels that resemble patterns of sugar drink consumption in young people, and which can remain long after exposure.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/185245