Persisting adiposity following chronic consumption of 10% sucrose solution: strain differences and behavioural effects.

Kendig, MD; Rooney, KB; Corbit, LH; Boakes, RA

Persisting adiposity following chronic consumption of 10% sucrose solution: strain differences and behavioural effects.

Kendig, MD Rooney, KB Corbit, LH Boakes, RA

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Publisher:: PERGAMON-ELSEVIER SCIENCE LTD
Publication Type:: Journal Article
Citation:: Physiol Behav, 2014, 130, pp. 54-65
Issue Date:: 2014-05-10

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Field	Value	Language
dc.contributor.author	Kendig, MD
dc.contributor.author	Rooney, KB
dc.contributor.author	Corbit, LH
dc.contributor.author	Boakes, RA
dc.date.accessioned	2025-02-21T03:56:56Z
dc.date.available	2014-03-13
dc.date.available	2025-02-21T03:56:56Z
dc.date.issued	2014-05-10
dc.identifier.citation	Physiol Behav, 2014, 130, pp. 54-65
dc.identifier.issn	0031-9384
dc.identifier.issn	1873-507X
dc.identifier.uri	http://hdl.handle.net/10453/185246
dc.description.abstract	The metabolic consequences of providing rats with extended access to sugar solutions have varied across studies. The two experiments in this study examined the effects of 8 weeks of 24-h access to 10% sucrose solution on adult Wistar rats. This was followed by 6 weeks of food restriction with no access to sucrose during which the behavioural effects of prior sucrose consumption on reward-oriented behaviour (Experiment 1) and reversal learning (Experiment 2) were assessed. In a comparison between rat strains, Experiment 1 found that sucrose accelerated weight gain in Albino but not Hooded Wistar rats, while sucrose-fed rats of both strains exhibited elevated fasting blood glucose and resistance to insulin. Importantly, at cull retroperitoneal fat deposits were elevated in sucrose-fed rats, at which point glucose and insulin had resolved to control levels and liver triglyceride content did not differ between groups. Experiment 2 also found that retroperitoneal fat content was higher in sucrose-fed rats at cull, after 6 weeks of behavioural testing without sucrose and with restricted access to food, and found a similar effect for epididymal fat. Behavioural testing in Experiment 1 found that sucrose exposure had no effect on habit formation assessed using an outcome devaluation paradigm. However, instrumental responding by sucrose-fed Albino rats was the least affected by pre-feeding, indicating a relationship between sucrose-induced obesity and food-seeking behaviour. In Experiment 2, sucrose-fed and control rats did not differ on a discrimination reversal task. In conclusion, this study demonstrates that the behavioural and metabolic effects of sucrose consumption vary with strain. Further, results indicate that sucrose consumption can lead to lasting increases in adipose tissue stores, a finding which has significant implications for human diets.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	PERGAMON-ELSEVIER SCIENCE LTD
dc.relation.ispartof	Physiol Behav
dc.relation.isbasedon	10.1016/j.physbeh.2014.03.021
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	06 Biological Sciences, 11 Medical and Health Sciences, 17 Psychology and Cognitive Sciences
dc.subject.classification	Behavioral Science & Comparative Psychology
dc.subject.classification	31 Biological sciences
dc.subject.classification	32 Biomedical and clinical sciences
dc.subject.classification	52 Psychology
dc.subject.mesh	Adipose Tissue
dc.subject.mesh	Adiposity
dc.subject.mesh	Animals
dc.subject.mesh	Appetitive Behavior
dc.subject.mesh	Blood Glucose
dc.subject.mesh	Body Weight
dc.subject.mesh	Conditioning, Operant
dc.subject.mesh	Dietary Sucrose
dc.subject.mesh	Discrimination, Psychological
dc.subject.mesh	Eating
dc.subject.mesh	Glucose Intolerance
dc.subject.mesh	Insulin Resistance
dc.subject.mesh	Male
dc.subject.mesh	Obesity
dc.subject.mesh	Rats
dc.subject.mesh	Rats, Wistar
dc.subject.mesh	Reversal Learning
dc.subject.mesh	Satiety Response
dc.subject.mesh	Species Specificity
dc.subject.mesh	Adipose Tissue
dc.subject.mesh	Animals
dc.subject.mesh	Rats
dc.subject.mesh	Rats, Wistar
dc.subject.mesh	Glucose Intolerance
dc.subject.mesh	Insulin Resistance
dc.subject.mesh	Obesity
dc.subject.mesh	Body Weight
dc.subject.mesh	Dietary Sucrose
dc.subject.mesh	Blood Glucose
dc.subject.mesh	Appetitive Behavior
dc.subject.mesh	Conditioning, Operant
dc.subject.mesh	Reversal Learning
dc.subject.mesh	Satiety Response
dc.subject.mesh	Species Specificity
dc.subject.mesh	Eating
dc.subject.mesh	Male
dc.subject.mesh	Adiposity
dc.subject.mesh	Discrimination, Psychological
dc.subject.mesh	Adipose Tissue
dc.subject.mesh	Adiposity
dc.subject.mesh	Animals
dc.subject.mesh	Appetitive Behavior
dc.subject.mesh	Blood Glucose
dc.subject.mesh	Body Weight
dc.subject.mesh	Conditioning, Operant
dc.subject.mesh	Dietary Sucrose
dc.subject.mesh	Discrimination, Psychological
dc.subject.mesh	Eating
dc.subject.mesh	Glucose Intolerance
dc.subject.mesh	Insulin Resistance
dc.subject.mesh	Male
dc.subject.mesh	Obesity
dc.subject.mesh	Rats
dc.subject.mesh	Rats, Wistar
dc.subject.mesh	Reversal Learning
dc.subject.mesh	Satiety Response
dc.subject.mesh	Species Specificity
dc.title	Persisting adiposity following chronic consumption of 10% sucrose solution: strain differences and behavioural effects.
dc.type	Journal Article
utslib.citation.volume	130
utslib.location.activity	United States
utslib.for	06 Biological Sciences
utslib.for	11 Medical and Health Sciences
utslib.for	17 Psychology and Cognitive Sciences
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Science
pubs.organisational-group	University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	University of Technology Sydney/UTS Groups
pubs.organisational-group	University of Technology Sydney/UTS Groups/Stroke Research Collaborative
utslib.copyright.status	closed_access	*
dc.date.updated	2025-02-21T03:56:54Z
pubs.publication-status	Published
pubs.volume	130

Abstract:

The metabolic consequences of providing rats with extended access to sugar solutions have varied across studies. The two experiments in this study examined the effects of 8 weeks of 24-h access to 10% sucrose solution on adult Wistar rats. This was followed by 6 weeks of food restriction with no access to sucrose during which the behavioural effects of prior sucrose consumption on reward-oriented behaviour (Experiment 1) and reversal learning (Experiment 2) were assessed. In a comparison between rat strains, Experiment 1 found that sucrose accelerated weight gain in Albino but not Hooded Wistar rats, while sucrose-fed rats of both strains exhibited elevated fasting blood glucose and resistance to insulin. Importantly, at cull retroperitoneal fat deposits were elevated in sucrose-fed rats, at which point glucose and insulin had resolved to control levels and liver triglyceride content did not differ between groups. Experiment 2 also found that retroperitoneal fat content was higher in sucrose-fed rats at cull, after 6 weeks of behavioural testing without sucrose and with restricted access to food, and found a similar effect for epididymal fat. Behavioural testing in Experiment 1 found that sucrose exposure had no effect on habit formation assessed using an outcome devaluation paradigm. However, instrumental responding by sucrose-fed Albino rats was the least affected by pre-feeding, indicating a relationship between sucrose-induced obesity and food-seeking behaviour. In Experiment 2, sucrose-fed and control rats did not differ on a discrimination reversal task. In conclusion, this study demonstrates that the behavioural and metabolic effects of sucrose consumption vary with strain. Further, results indicate that sucrose consumption can lead to lasting increases in adipose tissue stores, a finding which has significant implications for human diets.

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http://hdl.handle.net/10453/185246