Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) contributes to interferon gamma-dependent natural killer cell protection from tumor metastasis
- Publisher:
- Rockefeller University Press
- Publication Type:
- Journal Article
- Citation:
- Journal Of Experimental Medicine, 2001, 193 (6), pp. 661 - 670
- Issue Date:
- 2001-01
Closed Access
Full metadata record
Field | Value | Language |
---|---|---|
dc.contributor.author | Cretney, E | en_US |
dc.contributor.author | Takeda, K | en_US |
dc.contributor.author | Wiltrout, RH | en_US |
dc.contributor.author | Sedger, LM | en_US |
dc.contributor.author | Kayagaki, N | en_US |
dc.contributor.author | Yagita, H | en_US |
dc.contributor.author | Okumura, K | en_US |
dc.date.issued | 2001-01 | en_US |
dc.identifier.citation | Journal Of Experimental Medicine, 2001, 193 (6), pp. 661 - 670 | en_US |
dc.identifier.issn | 0022-1007 | en_US |
dc.identifier.uri | http://hdl.handle.net/10453/18702 | |
dc.description.abstract | Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is expressed by in vitro activated natural killer (NK) cells, but the relevance of this observation to the biological function of NK cells has been unclear. Herein, we have demonstrated the in vivo induction of mouse TRAIL expression on various tissue NK cells and correlated NK cell activation with TRAIL-mediated antimetastatic function in vivo. Expression of TRAIL was only constitutive on a subset of liver NK cells, and innate NK cell control of Renca carcinoma hepatic metastases in the liver was partially TRAIL dependent. Administration of therapeutic doses of interleukin (IL)-12, a powerful inducer of interferon (IFN)-gamma production by NK cells and NKT cells, upregulated TRAIL expression on liver, spleen, and lung NK cells, and IL-12 suppressed metastases in both liver and lung in a TRAIL-dependent fashion. By contrast, alpha -galactosylceramide (alpha -GalCer), a powerful inducer of NKT cell IFN-gamma and IL-4 secretion, suppressed both liver and lung metastases but only stimulated NK cell TRAIL-mediated function in the liver. TRAIL. expression was not detected on NK cells from IFN-gamma -deficient mice and TRAIL-mediated antimetastatic effects of IL-12 and a-GalCer were strictly IFN-gamma dependent. These results indicated that TRAIL induction on NK cells plays a critical role in IFN-gamma -mediated antimetastatic effects of IL-12 and alpha -GalCer. | en_US |
dc.format | Scott McWhirter | en_US |
dc.publisher | Rockefeller University Press | en_US |
dc.relation.ispartof | Journal Of Experimental Medicine | en_US |
dc.relation.isbasedon | 10.1084/jem.193.6.661 | en_US |
dc.subject.classification | Immunology | en_US |
dc.subject.mesh | Killer Cells, Natural | en_US |
dc.subject.mesh | Tumor Cells, Cultured | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Mice, Inbred BALB C | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Mice | en_US |
dc.subject.mesh | Carcinoma, Renal Cell | en_US |
dc.subject.mesh | Liver Neoplasms | en_US |
dc.subject.mesh | Kidney Neoplasms | en_US |
dc.subject.mesh | Neoplasm Metastasis | en_US |
dc.subject.mesh | Galactosylceramides | en_US |
dc.subject.mesh | Tumor Necrosis Factor-alpha | en_US |
dc.subject.mesh | Membrane Glycoproteins | en_US |
dc.subject.mesh | Interleukin-2 | en_US |
dc.subject.mesh | Interleukin-12 | en_US |
dc.subject.mesh | Ligands | en_US |
dc.subject.mesh | Cytotoxicity, Immunologic | en_US |
dc.subject.mesh | Tissue Distribution | en_US |
dc.subject.mesh | Apoptosis Regulatory Proteins | en_US |
dc.subject.mesh | TNF-Related Apoptosis-Inducing Ligand | en_US |
dc.subject.mesh | Interferon-gamma | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Apoptosis Regulatory Proteins | en_US |
dc.subject.mesh | Carcinoma, Renal Cell | en_US |
dc.subject.mesh | Cytotoxicity, Immunologic | en_US |
dc.subject.mesh | Galactosylceramides | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Interferon-gamma | en_US |
dc.subject.mesh | Interleukin-12 | en_US |
dc.subject.mesh | Interleukin-2 | en_US |
dc.subject.mesh | Kidney Neoplasms | en_US |
dc.subject.mesh | Killer Cells, Natural | en_US |
dc.subject.mesh | Ligands | en_US |
dc.subject.mesh | Liver Neoplasms | en_US |
dc.subject.mesh | Membrane Glycoproteins | en_US |
dc.subject.mesh | Mice | en_US |
dc.subject.mesh | Mice, Inbred BALB C | en_US |
dc.subject.mesh | Neoplasm Metastasis | en_US |
dc.subject.mesh | TNF-Related Apoptosis-Inducing Ligand | en_US |
dc.subject.mesh | Tissue Distribution | en_US |
dc.subject.mesh | Tumor Cells, Cultured | en_US |
dc.subject.mesh | Tumor Necrosis Factor-alpha | en_US |
dc.title | Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) contributes to interferon gamma-dependent natural killer cell protection from tumor metastasis | en_US |
dc.type | Journal Article | |
utslib.citation.volume | 6 | en_US |
utslib.citation.volume | 193 | en_US |
utslib.for | 11 Medical and Health Sciences | en_US |
utslib.for | 11 Medical And Health Sciences | en_US |
pubs.embargo.period | Not known | en_US |
pubs.organisational-group | /University of Technology Sydney | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Science | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Science/School of Life Sciences | |
utslib.copyright.status | closed_access | |
pubs.consider-herdc | false | en_US |
pubs.issue | 6 | en_US |
pubs.notes | Ok-SAM | en_US |
pubs.volume | 193 | en_US |
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Abstract:
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is expressed by in vitro activated natural killer (NK) cells, but the relevance of this observation to the biological function of NK cells has been unclear. Herein, we have demonstrated the in vivo induction of mouse TRAIL expression on various tissue NK cells and correlated NK cell activation with TRAIL-mediated antimetastatic function in vivo. Expression of TRAIL was only constitutive on a subset of liver NK cells, and innate NK cell control of Renca carcinoma hepatic metastases in the liver was partially TRAIL dependent. Administration of therapeutic doses of interleukin (IL)-12, a powerful inducer of interferon (IFN)-gamma production by NK cells and NKT cells, upregulated TRAIL expression on liver, spleen, and lung NK cells, and IL-12 suppressed metastases in both liver and lung in a TRAIL-dependent fashion. By contrast, alpha -galactosylceramide (alpha -GalCer), a powerful inducer of NKT cell IFN-gamma and IL-4 secretion, suppressed both liver and lung metastases but only stimulated NK cell TRAIL-mediated function in the liver. TRAIL. expression was not detected on NK cells from IFN-gamma -deficient mice and TRAIL-mediated antimetastatic effects of IL-12 and a-GalCer were strictly IFN-gamma dependent. These results indicated that TRAIL induction on NK cells plays a critical role in IFN-gamma -mediated antimetastatic effects of IL-12 and alpha -GalCer.
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