Developing biomimetic scaffolds for osteochondral tissue engineering

Lin, Xiaoqi

Developing biomimetic scaffolds for osteochondral tissue engineering

Lin, Xiaoqi

Permalink

Publication Type:: Thesis
Issue Date:: 2025

Open Access

Copyright Clearance Process

Recently Added
In Progress
Open Access

This item is open access.

Adobe PDF

Download thesisAdobe PDF (11.98 MB)

View statistics

Full metadata record

Field	Value	Language
dc.contributor.author	Lin, Xiaoqi
dc.date.accessioned	2025-12-18T00:50:15Z
dc.date.available	2025-12-18T00:50:15Z
dc.date.issued	2025
dc.identifier.uri	http://hdl.handle.net/10453/190964
dc.description	University of Technology Sydney. Faculty of Engineering and Information Technology.	en_US.UTF-8
dc.description.abstract	Chondral and osteochondral tissues are essential for joint function, providing mechanical support and enabling smooth movement through lubrication. However, the limited self-healing capacity of articular cartilage makes repairing stratified chondral defects particularly challenging. Untreated articular cartilage damage can lead to irreversible joint degeneration and increase the risk of osteoarthritis progression. This project aimed to address these challenges by developing multizonal chondral scaffolds capable of restoring the zonal structure of cartilage tissue. The central hypothesis was that a biomimetic, multilayered scaffold could promote zonal cartilage regeneration. To achieve this, the study focused on designing scaffolds with distinct structural zones and compositional gradients, mimicking the superficial, middle, and deep layers of native cartilage. A key aspect of the design was the integration of silk fibres, facilitating a transition from a fibrous superficial layer to a porous architecture that enhances cell attachment and growth. Experimental results demonstrated that the multizonal scaffold successfully combined three distinct layers while maintaining cell viability. This research advances cartilage tissue engineering by presenting a biomimetic scaffold design and offers valuable insights into bioactive, biodegradable materials for improved cartilage repair strategies in orthopaedic medicine.	en_US.UTF-8
dc.format	Thesis (ME)
dc.language.iso	en_US	en_US.UTF-8
dc.relation	https://opus.lib.uts.edu.au/bitstream/10453/190964/1/thesis.pdf
dc.rights	info:eu-repo/semantics/openAccess
dc.rights	The author owns the copyright in this thesis including all reproduction and reuse rights for the work. The work may not be altered without the permission of the copyright owner. Attribution is essential when quoting or paraphrasing from this thesis.
dc.rights	© 2025 Xiaoqi Lin
dc.rights	au.edu.uts.lib/cph
dc.title	Developing biomimetic scaffolds for osteochondral tissue engineering	en_US.UTF-8
dc.type	Thesis
utslib.copyright.status	open_access	*

Abstract:

Chondral and osteochondral tissues are essential for joint function, providing mechanical support and enabling smooth movement through lubrication. However, the limited self-healing capacity of articular cartilage makes repairing stratified chondral defects particularly challenging. Untreated articular cartilage damage can lead to irreversible joint degeneration and increase the risk of osteoarthritis progression. This project aimed to address these challenges by developing multizonal chondral scaffolds capable of restoring the zonal structure of cartilage tissue. The central hypothesis was that a biomimetic, multilayered scaffold could promote zonal cartilage regeneration. To achieve this, the study focused on designing scaffolds with distinct structural zones and compositional gradients, mimicking the superficial, middle, and deep layers of native cartilage. A key aspect of the design was the integration of silk fibres, facilitating a transition from a fibrous superficial layer to a porous architecture that enhances cell attachment and growth. Experimental results demonstrated that the multizonal scaffold successfully combined three distinct layers while maintaining cell viability. This research advances cartilage tissue engineering by presenting a biomimetic scaffold design and offers valuable insights into bioactive, biodegradable materials for improved cartilage repair strategies in orthopaedic medicine.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/190964