Beyond Infection: A Case of Doxycycline-Induced Mania and Prolonged Neuropsychiatric Disturbance.

Lim, ECN; Cheng, NCL; Lim, CED

Beyond Infection: A Case of Doxycycline-Induced Mania and Prolonged Neuropsychiatric Disturbance.

Lim, ECN Cheng, NCL Lim, CED

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Publisher:: Springer Nature
Publication Type:: Journal Article
Citation:: Cureus, 2025, 17, (2), pp. e79671
Issue Date:: 2025-02

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Field	Value	Language
dc.contributor.author	Lim, ECN
dc.contributor.author	Cheng, NCL
dc.contributor.author	Lim, CED
dc.date.accessioned	2026-02-03T08:06:52Z
dc.date.available	2025-02-25
dc.date.available	2026-02-03T08:06:52Z
dc.date.issued	2025-02
dc.identifier.citation	Cureus, 2025, 17, (2), pp. e79671
dc.identifier.issn	2168-8184
dc.identifier.issn	2168-8184
dc.identifier.uri	http://hdl.handle.net/10453/192742
dc.description.abstract	Doxycycline is commonly used in respiratory medicine to treat bacterial lower respiratory tract infections and is also a frequent choice in dermatology for various skin conditions. However, neuropsychiatric adverse reactions to doxycycline are rarely documented in the literature. Even less frequently reported is the persistence of such reactions for up to six weeks after discontinuing a 100 mg doxycycline tablet. We present a rare case of doxycycline-induced mania and psychosis in a patient who had taken the antibiotic for only three days, yet experienced severe neuropsychiatric symptoms that lasted for six weeks after treatment cessation. This case highlights the need for further research to identify the underlying mechanisms, high-risk populations, and implications for informed consent and clinical recommendations.
dc.format	Electronic-eCollection
dc.language	eng
dc.publisher	Springer Nature
dc.relation.ispartof	Cureus
dc.relation.isbasedon	10.7759/cureus.79671
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	11 Medical and Health Sciences
dc.subject.classification	32 Biomedical and clinical sciences
dc.subject.classification	42 Health sciences
dc.title	Beyond Infection: A Case of Doxycycline-Induced Mania and Prolonged Neuropsychiatric Disturbance.
dc.type	Journal Article
utslib.citation.volume	17
utslib.location.activity	United States
utslib.for	11 Medical and Health Sciences
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Science
pubs.organisational-group	University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	open_access	*
dc.rights.license	This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0). To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/
dc.date.updated	2026-02-03T08:06:51Z
pubs.issue	2
pubs.publication-status	Published online
pubs.volume	17
utslib.citation.issue	2

Abstract:

Doxycycline is commonly used in respiratory medicine to treat bacterial lower respiratory tract infections and is also a frequent choice in dermatology for various skin conditions. However, neuropsychiatric adverse reactions to doxycycline are rarely documented in the literature. Even less frequently reported is the persistence of such reactions for up to six weeks after discontinuing a 100 mg doxycycline tablet. We present a rare case of doxycycline-induced mania and psychosis in a patient who had taken the antibiotic for only three days, yet experienced severe neuropsychiatric symptoms that lasted for six weeks after treatment cessation. This case highlights the need for further research to identify the underlying mechanisms, high-risk populations, and implications for informed consent and clinical recommendations.

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http://hdl.handle.net/10453/192742