Lysosome-Targeted Squaramide Anion Transporters.

Feo, E; York, E; Thai, A; Ryder, WG; McNaughton, DA; Gale, PA

Lysosome-Targeted Squaramide Anion Transporters.

Feo, E York, E Thai, A Ryder, WG McNaughton, DA Gale, PA

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Publisher:: WILEY-V C H VERLAG GMBH
Publication Type:: Journal Article
Citation:: Chemistry, 2026, 32, (36), pp. e71243
Issue Date:: 2026-09-24

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Field	Value	Language
dc.contributor.author	Feo, E
dc.contributor.author	York, E
dc.contributor.author	Thai, A
dc.contributor.author	Ryder, WG
dc.contributor.author	McNaughton, DA
dc.contributor.author	Gale, PA
dc.date.accessioned	2026-10-09T02:29:46Z
dc.date.available	2026-05-30
dc.date.available	2026-10-09T02:29:46Z
dc.date.issued	2026-09-24
dc.identifier.citation	Chemistry, 2026, 32, (36), pp. e71243
dc.identifier.issn	0947-6539
dc.identifier.issn	1521-3765
dc.identifier.uri	http://hdl.handle.net/10453/196788
dc.description.abstract	Targeting anion transporters to specific organelles has previously been shown to be an effective strategy to enhance their cytotoxicities against cancerous cell lines. In this work a new family of squaramide anion transporters appended with two different lysosome targeting groups via a 1,4-substituted benzene spacer were synthesised. Cell viability studies showed that the transporters containing the N,N-dimethylamine targeting group exhibited the greatest cytotoxic effects despite possessing lower transport activities than the non-targeted control compounds and those containing the morpholine targeting group. Subcellular localisation studies using anthracene-labelled squaramides found that both targeting motifs successfully directed compounds to the lysosome, but the morpholine-containing motif accumulated to a lesser extent.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	WILEY-V C H VERLAG GMBH
dc.relation.ispartof	Chemistry
dc.relation.isbasedon	10.1002/chem.71243
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	03 Chemical Sciences
dc.subject.classification	General Chemistry
dc.subject.classification	34 Chemical sciences
dc.subject.mesh	Lysosomes
dc.subject.mesh	Humans
dc.subject.mesh	Quinine
dc.subject.mesh	Cell Survival
dc.subject.mesh	Anions
dc.subject.mesh	Cell Line, Tumor
dc.subject.mesh	Anthracenes
dc.subject.mesh	Morpholines
dc.title	Lysosome-Targeted Squaramide Anion Transporters.
dc.type	Journal Article
utslib.citation.volume	32
utslib.location.activity	Germany
utslib.for	03 Chemical Sciences
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Science
pubs.organisational-group	University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	University of Technology Sydney/UTS Groups
pubs.organisational-group	University of Technology Sydney/UTS Groups/The Kidman Centre (TKC)
utslib.copyright.status	open_access	*
dc.rights.license	This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0). To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/
dc.date.updated	2026-10-09T02:29:45Z
pubs.issue	36
pubs.publication-status	Published
pubs.volume	32
utslib.citation.issue	36

Abstract:

Targeting anion transporters to specific organelles has previously been shown to be an effective strategy to enhance their cytotoxicities against cancerous cell lines. In this work a new family of squaramide anion transporters appended with two different lysosome targeting groups via a 1,4-substituted benzene spacer were synthesised. Cell viability studies showed that the transporters containing the N,N-dimethylamine targeting group exhibited the greatest cytotoxic effects despite possessing lower transport activities than the non-targeted control compounds and those containing the morpholine targeting group. Subcellular localisation studies using anthracene-labelled squaramides found that both targeting motifs successfully directed compounds to the lysosome, but the morpholine-containing motif accumulated to a lesser extent.

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http://hdl.handle.net/10453/196788