Fasciola hepatica virulence-associated cysteine peptidases: A systems biology perspective

McVeigh, P; Maule, AG; Dalton, JP; Robinson, MW

Fasciola hepatica virulence-associated cysteine peptidases: A systems biology perspective

McVeigh, P Maule, AG Dalton, JP Robinson, MW

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Publication Type:: Journal Article
Citation:: Microbes and Infection, 2012, 14 (4), pp. 301 - 310
Issue Date:: 2012-04-01

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Field	Value	Language
dc.contributor.author	McVeigh, P	en_US
dc.contributor.author	Maule, AG	en_US
dc.contributor.author	Dalton, JP	en_US
dc.contributor.author	Robinson, MW	en_US
dc.date.available	2011-11-17	en_US
dc.date.issued	2012-04-01	en_US
dc.identifier.citation	Microbes and Infection, 2012, 14 (4), pp. 301 - 310	en_US
dc.identifier.issn	1286-4579	en_US
dc.identifier.uri	http://hdl.handle.net/10453/22141
dc.description.abstract	Fasciola hepatica is a food-borne parasite of animals and humans. It secretes a large family of cysteine peptidases, termed cathepsins, that are important virulence factors. Here, we discuss how advances in molecular technologies have helped to probe the function of liver fluke cathepsins, and consider how evolving systems/molecular biology approaches can continue to inform our understanding of these important parasite enzymes. © 2011 Institut Pasteur.	en_US
dc.relation.ispartof	Microbes and Infection	en_US
dc.relation.isbasedon	10.1016/j.micinf.2011.11.012	en_US
dc.subject.classification	Microbiology	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Fasciola hepatica	en_US
dc.subject.mesh	Cathepsins	en_US
dc.subject.mesh	Cysteine Endopeptidases	en_US
dc.subject.mesh	Virulence Factors	en_US
dc.subject.mesh	Proteomics	en_US
dc.subject.mesh	Genomics	en_US
dc.subject.mesh	Gene Silencing	en_US
dc.subject.mesh	RNA Interference	en_US
dc.subject.mesh	Protein Transport	en_US
dc.subject.mesh	Research	en_US
dc.subject.mesh	Transcriptome	en_US
dc.title	Fasciola hepatica virulence-associated cysteine peptidases: A systems biology perspective	en_US
dc.type	Journal Article
utslib.citation.volume	4	en_US
utslib.citation.volume	14	en_US
utslib.for	0605 Microbiology	en_US
utslib.for	1107 Immunology	en_US
utslib.for	1108 Medical Microbiology	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	closed_access
pubs.issue	4	en_US
pubs.publication-status	Published	en_US
pubs.volume	14	en_US

Abstract:

Fasciola hepatica is a food-borne parasite of animals and humans. It secretes a large family of cysteine peptidases, termed cathepsins, that are important virulence factors. Here, we discuss how advances in molecular technologies have helped to probe the function of liver fluke cathepsins, and consider how evolving systems/molecular biology approaches can continue to inform our understanding of these important parasite enzymes. © 2011 Institut Pasteur.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/22141