Defense peptides secreted by helminth pathogens: Antimicrobial and/or immunomodulator molecules?

Cotton, S; Donnelly, S; Robinson, MW; Dalton, JP; Thivierge, K

Defense peptides secreted by helminth pathogens: Antimicrobial and/or immunomodulator molecules?

Cotton, S Donnelly, S

Robinson, MW

Dalton, JP Thivierge, K

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Publication Type:: Journal Article
Citation:: Frontiers in Immunology, 2012, 3 (AUG)
Issue Date:: 2012-12-01

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Field	Value	Language
dc.contributor.author	Cotton, S	en_US
dc.contributor.author	Donnelly, S https://orcid.org/0000-0003-2005-3698	en_US
dc.contributor.author	Robinson, MW https://orcid.org/0000-0001-7191-0034	en_US
dc.contributor.author	Dalton, JP	en_US
dc.contributor.author	Thivierge, K	en_US
dc.date.available	2012-08-07	en_US
dc.date.issued	2012-12-01	en_US
dc.identifier.citation	Frontiers in Immunology, 2012, 3 (AUG)	en_US
dc.identifier.uri	http://hdl.handle.net/10453/22183
dc.description.abstract	Host defense peptides (HDPs) are an evolutionarily conserved component of the innate immune response found in all living species. They possess antimicrobial activities against a broad range of organisms including bacteria, fungi, eukaryotic parasites, and viruses. HDPs also have the ability to enhance immune responses by acting as immunomodulators. We discovered a new family of HDPs derived from pathogenic helminth (worms) that cause enormous disease in animals and humans worldwide. The discovery of these peptides was based on their similar biochemical and functional characteristics to the human defense peptide LL-37. We propose that these new peptides modulate the immune response via molecular mimicry of mammalian HDPs thus providing a mechanism behind the anti-inflammatory properties of helminth infections. © 2012 Cotton, Donnelly, Robinson, Dalton and Thivierge.	en_US
dc.relation.ispartof	Frontiers in Immunology	en_US
dc.relation.isbasedon	10.3389/fimmu.2012.00269	en_US
dc.title	Defense peptides secreted by helminth pathogens: Antimicrobial and/or immunomodulator molecules?	en_US
dc.type	Journal Article
utslib.citation.volume	AUG	en_US
utslib.citation.volume	3	en_US
utslib.for	0605 Microbiology	en_US
utslib.for	1107 Immunology	en_US
utslib.for	1108 Medical Microbiology	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	closed_access
pubs.issue	AUG	en_US
pubs.publication-status	Published	en_US
pubs.volume	3	en_US

Abstract:

Host defense peptides (HDPs) are an evolutionarily conserved component of the innate immune response found in all living species. They possess antimicrobial activities against a broad range of organisms including bacteria, fungi, eukaryotic parasites, and viruses. HDPs also have the ability to enhance immune responses by acting as immunomodulators. We discovered a new family of HDPs derived from pathogenic helminth (worms) that cause enormous disease in animals and humans worldwide. The discovery of these peptides was based on their similar biochemical and functional characteristics to the human defense peptide LL-37. We propose that these new peptides modulate the immune response via molecular mimicry of mammalian HDPs thus providing a mechanism behind the anti-inflammatory properties of helminth infections. © 2012 Cotton, Donnelly, Robinson, Dalton and Thivierge.

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http://hdl.handle.net/10453/22183