Artesunate-clindamycin multi-kinetics and site-specific oral delivery system for antimalaric combination products

Elsevier B.V.
Publication Type:
Journal Article
Journal of Controlled Release, 2010, 146 (1), pp. 54 - 60
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The aim of this work was to study a multi-kinetics and site-specific oral antimalaria drug delivery system (MKS_DDS), containing artesunate and clindamycin, based on the Dome Matrix® module assembly technology. The MKS_DDS assembled system comprises of four modules, i.e., two controlled release (CR) modules for delivery of 160 mg of clindamycin phosphate, one immediate release module containing 50 mg of artesunate and one immediate release module containing 80 mg of clindamycin phosphate. These modules have been assembled in stacked and void configurations.
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