Considerations for measuring iron in post-mortem tissue of Parkinson's disease patients

Hare, DJ; Gerlach, M; Riederer, P

Considerations for measuring iron in post-mortem tissue of Parkinson's disease patients

Hare, DJ

Gerlach, M Riederer, P

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Publication Type:: Journal Article
Citation:: Journal of Neural Transmission, 2012, 119 (12), pp. 1515 - 1521
Issue Date:: 2012-12-01

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Field	Value	Language
dc.contributor.author	Hare, DJ https://orcid.org/0000-0002-5922-7643	en_US
dc.contributor.author	Gerlach, M	en_US
dc.contributor.author	Riederer, P	en_US
dc.date.available	2012-09-03	en_US
dc.date.issued	2012-12-01	en_US
dc.identifier.citation	Journal of Neural Transmission, 2012, 119 (12), pp. 1515 - 1521	en_US
dc.identifier.issn	0300-9564	en_US
dc.identifier.uri	http://hdl.handle.net/10453/22508
dc.description.abstract	Redox-active iron is considered to be an important factor in the pathology and progression of several neurodegenerative disorders, including Parkinson's disease. The various roles of iron in normal physiology and its prevalence in the wider environment present numerous challenges to both accurate measurement and interpretation of brain iron levels. This review will discuss considerations for the analysis of iron in post-mortem samples, including how contamination, sample preparation and methods of analysis may influence results. In addition, several important factors influencing interpretation of iron levels will be considered. © 2012 Springer-Verlag.	en_US
dc.relation.ispartof	Journal of Neural Transmission	en_US
dc.relation.isbasedon	10.1007/s00702-012-0898-4	en_US
dc.subject.classification	Neurology & Neurosurgery	en_US
dc.subject.mesh	Brain	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Parkinson Disease	en_US
dc.subject.mesh	Iron	en_US
dc.subject.mesh	Specimen Handling	en_US
dc.subject.mesh	Autopsy	en_US
dc.subject.mesh	Tissue Fixation	en_US
dc.subject.mesh	Selection Bias	en_US
dc.title	Considerations for measuring iron in post-mortem tissue of Parkinson's disease patients	en_US
dc.type	Journal Article
utslib.citation.volume	12	en_US
utslib.citation.volume	119	en_US
utslib.for	1109 Neurosciences	en_US
utslib.for	1701 Psychology	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
utslib.copyright.status	closed_access
pubs.issue	12	en_US
pubs.publication-status	Published	en_US
pubs.volume	119	en_US

Abstract:

Redox-active iron is considered to be an important factor in the pathology and progression of several neurodegenerative disorders, including Parkinson's disease. The various roles of iron in normal physiology and its prevalence in the wider environment present numerous challenges to both accurate measurement and interpretation of brain iron levels. This review will discuss considerations for the analysis of iron in post-mortem samples, including how contamination, sample preparation and methods of analysis may influence results. In addition, several important factors influencing interpretation of iron levels will be considered. © 2012 Springer-Verlag.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/22508