Urine adulteration: Can bleach be used to mask MDMA use?

Pham, AQN; Kelly, T; Fu, S

Urine adulteration: Can bleach be used to mask MDMA use?

Pham, AQN Kelly, T

Fu, S

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Publication Type:: Journal Article
Citation:: Analytical Methods, 2013, 5 (16), pp. 3948 - 3955
Issue Date:: 2013-08-21

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Field	Value	Language
dc.contributor.author	Pham, AQN	en_US
dc.contributor.author	Kelly, T https://orcid.org/0000-0002-8946-9686	en_US
dc.contributor.author	Fu, S https://orcid.org/0000-0002-6238-3612	en_US
dc.date.issued	2013-08-21	en_US
dc.identifier.citation	Analytical Methods, 2013, 5 (16), pp. 3948 - 3955	en_US
dc.identifier.issn	1759-9660	en_US
dc.identifier.uri	http://hdl.handle.net/10453/23564
dc.description.abstract	Concerns regarding specimen integrity have long been a major issue of urine drug testing due to acts of urine adulteration. At a high concentration, in vitro urine adulteration using sodium hypochlorite (bleach) produced false-negative results for 3,4-methylenedioxymethamphetamine (MDMA) in CEDIA® immunoassay screening with strong negative readings. However, these strong negative readings may act as a warning sign for further investigation of the sample where the detection of a unique marker in the form of N-chloroMDMA will suggest urine adulteration via bleach. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) identified N-chloroMDMA is a major product formed between hypochlorite and MDMA in urine. N-ChloroMDMA was found stable at 4°C for at least 10 h, but decomposed over time at room temperature (20°C) with MDMA being identified as one of its main decomposition products. © 2013 The Royal Society of Chemistry.	en_US
dc.relation.ispartof	Analytical Methods	en_US
dc.relation.isbasedon	10.1039/c3ay40543e	en_US
dc.title	Urine adulteration: Can bleach be used to mask MDMA use?	en_US
dc.type	Journal Article
utslib.citation.volume	16	en_US
utslib.citation.volume	5	en_US
utslib.for	0301 Analytical Chemistry	en_US
utslib.for	0399 Other Chemical Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - CCET - Centre for Clean Energy Technology
pubs.organisational-group	/University of Technology Sydney/Strength - CFS - Centre for Forensic Science
utslib.copyright.status	open_access
pubs.issue	16	en_US
pubs.publication-status	Published	en_US
pubs.volume	5	en_US

Abstract:

Concerns regarding specimen integrity have long been a major issue of urine drug testing due to acts of urine adulteration. At a high concentration, in vitro urine adulteration using sodium hypochlorite (bleach) produced false-negative results for 3,4-methylenedioxymethamphetamine (MDMA) in CEDIA® immunoassay screening with strong negative readings. However, these strong negative readings may act as a warning sign for further investigation of the sample where the detection of a unique marker in the form of N-chloroMDMA will suggest urine adulteration via bleach. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) identified N-chloroMDMA is a major product formed between hypochlorite and MDMA in urine. N-ChloroMDMA was found stable at 4°C for at least 10 h, but decomposed over time at room temperature (20°C) with MDMA being identified as one of its main decomposition products. © 2013 The Royal Society of Chemistry.

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http://hdl.handle.net/10453/23564