Urine adulteration: can bleach be used to mask MDMA use?

Publisher:
Royal Society of Chemistry
Publication Type:
Journal Article
Citation:
Analytical Methods, 2013, 5 (16), pp. 3948 - 3955
Issue Date:
2013-01
Full metadata record
Files in This Item:
Filename Description Size
Urine adulteration.pdf426.36 kB
Adobe PDF
Concerns regarding specimen integrity have long been a major issue of urine drug testing due to acts of urine adulteration. At a high concentration, in vitro urine adulteration using sodium hypochlorite (bleach) produced false-negative results for 3,4-methylenedioxymethamphetamine (MDMA) in CEDIA immunoassay screening with strong negative readings. However, these strong negative readings may act as a warning sign for further investigation of the sample where the detection of a unique marker in the form of N-chloroMDMA will suggest urine adulteration via bleach. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) identi?ed N-chloroMDMA is a major product formed between hypochlorite and MDMA in urine. N-ChloroMDMA was found stable at 4 C for at least 10 h, but decomposed over time at room temperature (20 C) with MDMA being identified as one of its main decomposition products
Please use this identifier to cite or link to this item: