Urine adulteration: Can bleach be used to mask MDMA use?

Publication Type:
Journal Article
Citation:
Analytical Methods, 2013, 5 (16), pp. 3948 - 3955
Issue Date:
2013-08-21
Metrics:
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Concerns regarding specimen integrity have long been a major issue of urine drug testing due to acts of urine adulteration. At a high concentration, in vitro urine adulteration using sodium hypochlorite (bleach) produced false-negative results for 3,4-methylenedioxymethamphetamine (MDMA) in CEDIA®immunoassay screening with strong negative readings. However, these strong negative readings may act as a warning sign for further investigation of the sample where the detection of a unique marker in the form of N-chloroMDMA will suggest urine adulteration via bleach. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) identified N-chloroMDMA is a major product formed between hypochlorite and MDMA in urine. N-ChloroMDMA was found stable at 4°C for at least 10 h, but decomposed over time at room temperature (20°C) with MDMA being identified as one of its main decomposition products. © 2013 The Royal Society of Chemistry.
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