Ciprofloxacin is actively transported across bronchial lung epithelial cells using a calu-3 air interface cell model

Ong, HX; Traini, D; Bebawy, M; Young, PM

Ciprofloxacin is actively transported across bronchial lung epithelial cells using a calu-3 air interface cell model

Ong, HX Traini, D

Bebawy, M

Young, PM

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Publication Type:: Journal Article
Citation:: Antimicrobial Agents and Chemotherapy, 2013, 57 (6), pp. 2535 - 2540
Issue Date:: 2013-06-01

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Field	Value	Language
dc.contributor.author	Ong, HX	en_US
dc.contributor.author	Traini, D https://orcid.org/0000-0002-7173-017X	en_US
dc.contributor.author	Bebawy, M https://orcid.org/0000-0003-2606-921X	en_US
dc.contributor.author	Young, PM https://orcid.org/0000-0002-4357-7999	en_US
dc.date.issued	2013-06-01	en_US
dc.identifier.citation	Antimicrobial Agents and Chemotherapy, 2013, 57 (6), pp. 2535 - 2540	en_US
dc.identifier.issn	0066-4804	en_US
dc.identifier.uri	http://hdl.handle.net/10453/23650
dc.description.abstract	Ciprofloxacin is a well-established broad-spectrum fluoroquinolone antibiotic that penetrates well into the lung tissues; still, the mechanisms of its transepithelial transport are unknown. The contributions of specific transporters, including multidrug efflux transporters, organic cation transporters, and organic anion-transporting polypeptide transporters, to the uptake of ciprofloxacin were investigated in vitro using an air interface bronchial epithelial model. Our results demonstrate that ciprofloxacin is subject to predominantly active influx and a slight efflux component. Copyright © 2013, American Society for Microbiology. All Rights Reserved.	en_US
dc.relation.ispartof	Antimicrobial Agents and Chemotherapy	en_US
dc.relation.isbasedon	10.1128/AAC.00306-13	en_US
dc.subject.classification	Microbiology	en_US
dc.subject.mesh	Lung	en_US
dc.subject.mesh	Bronchi	en_US
dc.subject.mesh	Cell Line	en_US
dc.subject.mesh	Epithelial Cells	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Ciprofloxacin	en_US
dc.subject.mesh	Organic Anion Transporters	en_US
dc.subject.mesh	Organic Cation Transport Proteins	en_US
dc.subject.mesh	Anti-Bacterial Agents	en_US
dc.subject.mesh	Biological Transport, Active	en_US
dc.subject.mesh	Models, Biological	en_US
dc.title	Ciprofloxacin is actively transported across bronchial lung epithelial cells using a calu-3 air interface cell model	en_US
dc.type	Journal Article
utslib.citation.volume	6	en_US
utslib.citation.volume	57	en_US
utslib.for	1115 Pharmacology and Pharmaceutical Sciences	en_US
utslib.for	0605 Microbiology	en_US
utslib.for	1108 Medical Microbiology	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	/University of Technology Sydney/Graduate School of Health
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	open_access
pubs.issue	6	en_US
pubs.publication-status	Published	en_US
pubs.volume	57	en_US

Abstract:

Ciprofloxacin is a well-established broad-spectrum fluoroquinolone antibiotic that penetrates well into the lung tissues; still, the mechanisms of its transepithelial transport are unknown. The contributions of specific transporters, including multidrug efflux transporters, organic cation transporters, and organic anion-transporting polypeptide transporters, to the uptake of ciprofloxacin were investigated in vitro using an air interface bronchial epithelial model. Our results demonstrate that ciprofloxacin is subject to predominantly active influx and a slight efflux component. Copyright © 2013, American Society for Microbiology. All Rights Reserved.

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http://hdl.handle.net/10453/23650