Immunomodulatory molecules of Fasciola hepatica:Candidates for both vaccine and immunotherapeuticdevelopment

Elsevier BV
Publication Type:
Journal Article
Veterinary Parasitology, 2013, 195 (3-4), pp. 272 - 285
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tThe liver fluke, Fasciola hepatica, causes fascioliasis in domestic animals (sheep, cattle),a global disease that is also an important infection of humans. As soon as the parasiteinvades the gut wall its interaction with various host immune cells (e.g. dendritic cells,macrophages and mast cells) is complex. The parasite secretes a myriad of molecules thatdirect the immune response towards a favourable non-protective Th2-mediate/regulatoryenvironment. These immunomodulatory molecules, such as cathepsin L peptidase (FhCL1),are under development as the first generation of fluke vaccines. However, this peptidase andother molecules, such as peroxiredoxin (FhPrx) and helminth defence molecule (FhHDM-1), exhibit various immunomodulatory properties that could be harnessed to help treatimmune-related conditions in humans and animals.
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